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    Oard1 O-acyl-ADP-ribose deacylase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367214, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Oard1provided by RGD
    Official Full Name
    O-acyl-ADP-ribose deacylase 1provided by RGD
    Primary source
    RGD:1308299
    See related
    AllianceGenome:RGD:1308299
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308299
    Summary
    Predicted to enable O-acetyl-ADP-ribose deacetylase activity; hydrolase activity, hydrolyzing N-glycosyl compounds; and purine nucleoside binding activity. Predicted to be involved in DNA damage response; peptidyl-glutamate ADP-deribosylation; and purine nucleoside metabolic process. Predicted to be located in nucleolus and site of DNA damage. Predicted to be active in nucleoplasm. Orthologous to human OARD1 (O-acyl-ADP-ribose deacylase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 74.8), Muscle (RPKM 70.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Oard1 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (20074507..20084946, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (12576894..12587264, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (14542957..14551519, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene unc-5 family C-terminal like Neighboring gene translocator protein 2 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 2 Neighboring gene nuclear transcription factor Y subunit alpha Neighboring gene triggering receptor expressed on myeloid cells-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Orphan macrodomain protein (human C6orf130) is an O-acyl-ADP-ribose deacylase: solution structure and catalytic properties. Peterson FC, et al. J Biol Chem, 2011 Oct 14. PMID 21849506, Free PMC Article
    2. Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription. Bütepage M, et al. Sci Rep, 2018 Apr 30. PMID 29712969, Free PMC Article
    3. Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease. Sharifi R, et al. EMBO J, 2013 May 2. PMID 23481255, Free PMC Article
    4. Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases. Rosenthal F, et al. Nat Struct Mol Biol, 2013 Apr. PMID 23474714
    5. Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation. Barkauskaite E, et al. Mol Cell, 2015 Jun 18. PMID 26091342

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP-ribosyl-[dinitrogen reductase] hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ADP-ribosylglutamate hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables O-acetyl-ADP-ribose deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables purine nucleoside binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in peptidyl-glutamate ADP-deribosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein de-ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine nucleoside metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleoside metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribose glycohydrolase OARD1
    Names
    O-acetyl-ADP-ribose deacetylase 1
    hypothetical 9.7 kDa protein dJ34B21.3
    NP_001386064.1
    NP_001386065.1
    NP_001386066.1
    NP_001386067.1
    XP_006244532.1
    XP_006244534.1
    XP_017452033.1
    XP_038939874.1
    XP_038939875.1
    XP_038939878.1
    XP_038939879.1
    XP_063123560.1
    XP_063123561.1
    XP_063123562.1
    XP_063123563.1
    XP_063123564.1
    XP_063123565.1
    XP_063123566.1
    XP_063123567.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399135.1 → NP_001386064.1  ADP-ribose glycohydrolase OARD1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K831
      Conserved Domains (1) summary
      cd02901
      Location:13 → 143
      Macro_Poa1p-like; macrodomain, Poa1p-like family

    2. NM_001399136.1 → NP_001386065.1  ADP-ribose glycohydrolase OARD1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K831
      Conserved Domains (1) summary
      cd02901
      Location:13 → 143
      Macro_Poa1p-like; macrodomain, Poa1p-like family

    3. NM_001399137.1 → NP_001386066.1  ADP-ribose glycohydrolase OARD1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K831
      Conserved Domains (1) summary
      cd02901
      Location:13 → 143
      Macro_Poa1p-like; macrodomain, Poa1p-like family

    4. NM_001399138.1 → NP_001386067.1  ADP-ribose glycohydrolase OARD1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K831
      Conserved Domains (1) summary
      cd02901
      Location:13 → 143
      Macro_Poa1p-like; macrodomain, Poa1p-like family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      20074507..20084946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267497.1 → XP_063123567.1  ADP-ribose glycohydrolase OARD1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K831

    2. XM_063267496.1 → XP_063123566.1  ADP-ribose glycohydrolase OARD1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K831

    3. XM_063267492.1 → XP_063123562.1  ADP-ribose glycohydrolase OARD1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K831

    4. XM_063267490.1 → XP_063123560.1  ADP-ribose glycohydrolase OARD1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K831

    5. XM_039083947.2 → XP_038939875.1  ADP-ribose glycohydrolase OARD1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K831
      Conserved Domains (1) summary
      cd02901
      Location:13 → 143
      Macro_Poa1p-like; macrodomain, Poa1p-like family

    6. XM_063267495.1 → XP_063123565.1  ADP-ribose glycohydrolase OARD1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K831

    7. XM_017596544.3 → XP_017452033.1  ADP-ribose glycohydrolase OARD1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K831
      Conserved Domains (1) summary
      cd02901
      Location:13 → 143
      Macro_Poa1p-like; macrodomain, Poa1p-like family

    8. XM_006244470.5 → XP_006244532.1  ADP-ribose glycohydrolase OARD1 isoform X1

      See identical proteins and their annotated locations for XP_006244532.1

      UniProtKB/TrEMBL
      A0A0G2K831
      Conserved Domains (1) summary
      cd02901
      Location:13 → 143
      Macro_Poa1p-like; macrodomain, Poa1p-like family

    9. XM_063267493.1 → XP_063123563.1  ADP-ribose glycohydrolase OARD1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K831

    10. XM_063267491.1 → XP_063123561.1  ADP-ribose glycohydrolase OARD1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K831

    11. XM_063267494.1 → XP_063123564.1  ADP-ribose glycohydrolase OARD1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K831

    12. XM_039083950.2 → XP_038939878.1  ADP-ribose glycohydrolase OARD1 isoform X2

      Conserved Domains (1) summary
      cd02901
      Location:1 → 104
      Macro_Poa1p-like; macrodomain, Poa1p-like family

    13. XM_006244472.5 → XP_006244534.1  ADP-ribose glycohydrolase OARD1 isoform X1

      See identical proteins and their annotated locations for XP_006244534.1

      UniProtKB/TrEMBL
      A0A0G2K831
      Conserved Domains (1) summary
      cd02901
      Location:13 → 143
      Macro_Poa1p-like; macrodomain, Poa1p-like family

    14. XM_039083946.2 → XP_038939874.1  ADP-ribose glycohydrolase OARD1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K831
      Conserved Domains (1) summary
      cd02901
      Location:13 → 143
      Macro_Poa1p-like; macrodomain, Poa1p-like family

    15. XM_039083951.2 → XP_038939879.1  ADP-ribose glycohydrolase OARD1 isoform X3

      Conserved Domains (1) summary
      cd02901
      Location:14 → 103
      Macro_Poa1p-like; macrodomain, Poa1p-like family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001134596.1: Suppressed sequence

      Description
      NM_001134596.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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