Kcnip4 potassium voltage-gated channel interacting protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnip4provided by RGD
Official Full Name: potassium voltage-gated channel interacting protein 4provided by RGD
Primary source: RGD:708539
See related: EnsemblRapid:ENSRNOG00000032350 AllianceGenome:RGD:708539
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kchip4
Summary: Enables potassium channel regulator activity. Involved in protein localization to plasma membrane and regulation of potassium ion transmembrane transport. Located in several cellular components, including cytosol; dendrite; and neuronal cell body. Part of voltage-gated potassium channel complex. Orthologous to human KCNIP4 (potassium voltage-gated channel interacting protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 158.8), Uterus (RPKM 43.9) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 14q11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (65593297..66743994)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (61380699..62531399)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (65549362..66749181)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Down-regulation of miR-3068-3p enhances kcnip4-regulated A-type potassium current to protect against glutamate-induced excitotoxicity.
Title: Down-regulation of miR-3068-3p enhances kcnip4-regulated A-type potassium current to protect against glutamate-induced excitotoxicity.
Subunit counting by single-molecule imaging revealed that the bound number of KChIP4 in each Kv4.2.KChIP4 complex was dependent on the expression level of KChIP4.
Title: The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression level.
This study demonistrared that the expression and function of KCHIP4 channels in neurons of the rat bed nucleus of the stria terminalis.
Title: Distribution and functional expression of Kv4 family α subunits and associated KChIP β subunits in the bed nucleus of the stria terminalis.
KChIP4a isoform, which exhibits unique effects on Kv4 channel gating negatively influences the impact of other KChIPs
Title: A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels.
KChIP4 coassociates with Kv4 subunits in hippocampal membranes, confirming that the KChIPs are tightly associated with Kv4 subunits in native brain A-type channel complexes which may play a major role as modulators of somatodendritic excitability.
Title: KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain.

Submit: New GeneRIF Correction

General gene information

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Markers

RH138347 (e-PCR)
- UniSTS:220434

BE113856 (e-PCR)
- UniSTS:246822

RH131556 (e-PCR)
- UniSTS:214839

RH144553 (e-PCR)
- UniSTS:233798

BE115263 (e-PCR)
- UniSTS:261466

D14Rat87 (e-PCR), detects polymorphism
- UniSTS:226659

D14Rat88 (e-PCR), detects polymorphism
- UniSTS:226660

BE114195 (e-PCR)
- UniSTS:247437

AU025346 (e-PCR)
- UniSTS:115352

AU025602 (e-PCR)
- UniSTS:115100

RH137736 (e-PCR)
- UniSTS:219823

AU026082 (e-PCR)
- UniSTS:114630

Kcnip4 (e-PCR), detects polymorphism
- UniSTS:478920

RH138036 (e-PCR)
- UniSTS:220123

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Kv channel-interacting protein 4

Names: A-type potassium channel modulatory protein 4; Kv channel interacting protein 4; potassium channel-interacting protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433864.1 → NP_001420793.1 Kv channel-interacting protein 4 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

G3V9C1
NM_181365.3 → NP_852030.1 Kv channel-interacting protein 4 isoform 1

See identical proteins and their annotated locations for NP_852030.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

Q99MG8, Q99MG9

UniProtKB/TrEMBL

G3V9C1

Related

ENSRNOP00000042016.6, ENSRNOT00000049743.6

Conserved Domains (1) summary

COG5126
Location:80 → 239

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

65593297..66743994

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272886.1 → XP_063128956.1 Kv channel-interacting protein 4 isoform X1

UniProtKB/TrEMBL

A6IJJ6, G3V9C1
XM_017599089.3 → XP_017454578.1 Kv channel-interacting protein 4 isoform X5

Related

ENSRNOP00000086123.2, ENSRNOT00000115304.2

Conserved Domains (1) summary

COG5126
Location:46 → 205

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
XM_017599088.3 → XP_017454577.1 Kv channel-interacting protein 4 isoform X4

UniProtKB/TrEMBL

A0A8I5ZMG1, G3V9C1

Related

ENSRNOP00000079125.1, ENSRNOT00000115977.2

Conserved Domains (1) summary

COG5126
Location:55 → 214

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
XM_017599087.3 → XP_017454576.1 Kv channel-interacting protein 4 isoform X3

UniProtKB/TrEMBL

A0A8I6A8J8, G3V9C1

Related

ENSRNOP00000089378.1, ENSRNOT00000114580.2

Conserved Domains (1) summary

COG5126
Location:59 → 218

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
XM_017599086.3 → XP_017454575.1 Kv channel-interacting protein 4 isoform X2

UniProtKB/TrEMBL

A0A8I5ZSB5, G3V9C1

Related

ENSRNOP00000075583.3, ENSRNOT00000079658.3

Conserved Domains (1) summary

COG5126
Location:63 → 222

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
XM_063272887.1 → XP_063128957.1 Kv channel-interacting protein 4 isoform X6

UniProtKB/TrEMBL

A0A0G2KAZ2, A6IJJ8, G3V9C1