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    ABCC2 multidrug resistance-associated protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818031, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ABCC2
    Official Full Name
    multidrug resistance-associated protein 2
    Primary source
    TAIR:AT2G34660
    Locus tag
    AT2G34660
    See related
    Araport:AT2G34660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ABC TRANSPORTER; Arabidopsis thaliana ATP-binding cassette C2; AtABCC2; ATMRP2; ATP-binding cassette C2; EST4; MRP2; multidrug resistance-associated protein 2; T29F13.13; T29F13_13
    Summary
    encodes a multidrug resistance-associated protein that is MgATP-energized glutathione S-conjugate pump. An ABCC-type arsenite-phytochelatin transporter. The expression of this gene is upregulated by herbicide safeners such as benoxacor and fenclorim.
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    Genomic context

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    See ABCC2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    27
    Sequence:
    Chromosome: 2; NC_003071.7 (14602470..14612565)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene uncharacterized protein Neighboring gene benzoyl-CoA reductase subunit C, putative (DUF630 and DUF632) Neighboring gene Outer arm dynein light chain 1 protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transport of Anthocyanins and other Flavonoids by the Arabidopsis ATP-Binding Cassette Transporter AtABCC2. Behrens CE, et al. Sci Rep, 2019 Jan 24. PMID 30679715, Free PMC Article
    2. Comparative mutant analysis of Arabidopsis ABCC-type ABC transporters: AtMRP2 contributes to detoxification, vacuolar organic anion transport and chlorophyll degradation. Frelet-Barrand A, et al. Plant Cell Physiol, 2008 Apr. PMID 18325934
    3. AtMRP2, an Arabidopsis ATP binding cassette transporter able to transport glutathione S-conjugates and chlorophyll catabolites: functional comparisons with Atmrp1. Lu YP, et al. Plant Cell, 1998 Feb. PMID 9490749, Free PMC Article
    4. Vacuolar transport of abscisic acid glucosyl ester is mediated by ATP-binding cassette and proton-antiport mechanisms in Arabidopsis. Burla B, et al. Plant Physiol, 2013 Nov. PMID 24028845, Free PMC Article
    5. The phytochelatin transporters AtABCC1 and AtABCC2 mediate tolerance to cadmium and mercury. Park J, et al. Plant J, 2012 Jan. PMID 21919981

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transport of acylated anthocyanins by the Arabidopsis ATP-binding cassette transporters AtABCC1, AtABCC2, and AtABCC14.
      Title: Transport of acylated anthocyanins by the Arabidopsis ATP-binding cassette transporters AtABCC1, AtABCC2, and AtABCC14.
    2. Data suggest that ATP-binding cassette transporter (AtABCC2) along with possibly other ABCC proteins are involved in the vacuolar transport of anthocyanins and other flavonoids in the vegetative tissue of Arabidopsis.
      Title: Transport of Anthocyanins and other Flavonoids by the Arabidopsis ATP-Binding Cassette Transporter AtABCC2.
    3. AtABCC1 and AtABCC2 are important vacuolar transporters that confer tolerance to cadmium and mercury, in addition to their role in arsenic detoxification.
      Title: The phytochelatin transporters AtABCC1 and AtABCC2 mediate tolerance to cadmium and mercury.
    4. Data show that the ABC transporters AtABCC1 (At1g30400) and AtABCC2 (AT2G34660) exhibit abscisic acid glucosyl ester (ABA-GE) transport activity in vitro.
      Title: Vacuolar transport of abscisic acid glucosyl ester is mediated by ATP-binding cassette and proton-antiport mechanisms in Arabidopsis.
    5. AtABCC1 and AtABCC2 are the long-sought and major vacuolar phytochelatin transporters
      Title: Arsenic tolerance in Arabidopsis is mediated by two ABCC-type phytochelatin transporters.
    6. This suggests that AtMRP2 is involved in vacuolar transport of chlorophyll catabolites.
      Title: Comparative mutant analysis of Arabidopsis ABCC-type ABC transporters: AtMRP2 contributes to detoxification, vacuolar organic anion transport and chlorophyll degradation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001202746.1
    NM_001336522.1
    NM_129020.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables (+)-abscisic acid D-glucopyranosyl ester transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ABC-type transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ABC-type xenobiotic transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within (+)-abscisic acid D-glucopyranosyl ester transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in vacuolar membrane HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    multidrug resistance-associated protein 2
    NP_001189675.1
    • multidrug resistance-associated protein 2 (MRP2); CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: multidrug resistance-associated protein 1 (TAIR:AT1G30400.2).
    NP_181013.1
    • multidrug resistance-associated protein 2 (MRP2); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances; INVOLVED IN: response to cyclopentenone; LOCATED IN: vacuolar membrane, plasma membrane, vacuole, plant-type vacuole; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: multidrug resistance-associated protein 1 (TAIR:AT1G30400.2); Has 677853 Blast hits to 353182 proteins in 3940 species: Archae - 12495; Bacteria - 548354; Metazoa - 12805; Fungi - 8204; Plants - 5931; Viruses - 21; Other Eukaryotes - 90043 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      14602470..14612565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202746.1 → NP_001189675.1  multidrug resistance-associated protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189675.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22449, O24526, O48907, O48908, O64590, Q42093
      UniProtKB/TrEMBL
      A0A654EYW8
      Conserved Domains (5) summary
      cd03244
      Location:1240 → 1460
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:614 → 815
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      PLN03130
      Location:1 → 1623
      PLN03130; ABC transporter C family member; Provisional
      pfam00664
      Location:309 → 570
      ABC_membrane; ABC transporter transmembrane region
      cl00549
      Location:925 → 1179
      ABC_membrane; ABC transporter transmembrane region

    2. NM_129020.3 → NP_181013.1  multidrug resistance-associated protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181013.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22449, O24526, O48907, O48908, O64590, Q42093
      UniProtKB/TrEMBL
      A0A654EYW8
      Conserved Domains (5) summary
      cd03244
      Location:1240 → 1460
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:614 → 815
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      PLN03130
      Location:1 → 1623
      PLN03130; ABC transporter C family member; Provisional
      pfam00664
      Location:309 → 570
      ABC_membrane; ABC transporter transmembrane region
      cl00549
      Location:925 → 1179
      ABC_membrane; ABC transporter transmembrane region

    3. NM_001336522.1 → NP_001324371.1  multidrug resistance-associated protein 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AZX4, A0A5S9X3W2, A0A654EYW8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42093.2

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