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    IREG1 iron regulated 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818427, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IREG1
    Official Full Name
    iron regulated 1
    Primary source
    TAIR:AT2G38460
    Locus tag
    AT2G38460
    See related
    Araport:AT2G38460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA IRON-REGULATED PROTEIN 1; ATIREG1; FERROPORTIN 1; FPN1; iron regulated 1; T19C21.5; T19C21_5
    Summary
    Encodes IRON REGULATED1 (IREG1/FPN1), one of the Arabidopsis orthologs (AT2G38460/IREG1/FPN1 and AT5G03570/IREG2/FPN2) the iron efflux transporter ferroportin (FPN) identified in animals.
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    Genomic context

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    See IREG1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (16103164..16106208)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene SCAR homolog 2 Neighboring gene Sel1 repeat protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene WRKY DNA-binding protein 33

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ferroportin metal efflux proteins function in iron and cobalt homeostasis in Arabidopsis. Morrissey J, et al. Plant Cell, 2009 Oct. PMID 19861554, Free PMC Article
    2. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
    3. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fpn1 function in iron and cobalt homeostasis in Arabidopsis.
      Title: The ferroportin metal efflux proteins function in iron and cobalt homeostasis in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001336702.1
    NM_001336703.1
    NM_001336704.1
    NM_001336705.1
    NM_129402.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables iron ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cobalt ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    iron regulated 1
    NP_181380.1
    • iron regulated 1 (IREG1); CONTAINS InterPro DOMAIN/s: Ferroporti-1 (InterPro:IPR009716), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: iron regulated 2 (TAIR:AT5G03570.2); Has 345 Blast hits to 287 proteins in 82 species: Archae - 0; Bacteria - 2; Metazoa - 164; Fungi - 61; Plants - 95; Viruses - 0; Other Eukaryotes - 23 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16103164..16106208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336699.1 → NP_001323536.1  iron regulated 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AXC7

    2. NM_001336700.1 → NP_001323537.1  iron regulated 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80905
      UniProtKB/TrEMBL
      A0A5S9X567, A0A654F014
      Conserved Domains (1) summary
      pfam06963
      Location:35 → 483
      FPN1; Ferroportin1 (FPN1)

    3. NM_001336701.1 → NP_001323539.1  iron regulated 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80905
      UniProtKB/TrEMBL
      A0A5S9X567, A0A654F014
      Conserved Domains (1) summary
      pfam06963
      Location:35 → 483
      FPN1; Ferroportin1 (FPN1)

    4. NM_129402.6 → NP_181380.1  iron regulated 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181380.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80905
      UniProtKB/TrEMBL
      A0A5S9X567, A0A654F014
      Conserved Domains (1) summary
      pfam06963
      Location:35 → 483
      FPN1; Ferroportin1 (FPN1)

    5. NM_001336702.1 → NP_001323540.1  iron regulated 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AXC7

    6. NM_001336703.1 → NP_001323535.1  iron regulated 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80905
      UniProtKB/TrEMBL
      A0A5S9X567, A0A654F014
      Conserved Domains (1) summary
      pfam06963
      Location:35 → 483
      FPN1; Ferroportin1 (FPN1)

    7. NM_001336704.1 → NP_001323538.1  iron regulated 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80905
      UniProtKB/TrEMBL
      A0A5S9X567, A0A654F014
      Conserved Domains (1) summary
      pfam06963
      Location:35 → 483
      FPN1; Ferroportin1 (FPN1)

    8. NM_001336705.1 → NP_001323541.1  iron regulated 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80905
      UniProtKB/TrEMBL
      A0A5S9X567, A0A654F014
      Conserved Domains (1) summary
      pfam06963
      Location:35 → 483
      FPN1; Ferroportin1 (FPN1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80905.1

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