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    TPX2 targeting protein for XKLP2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839140, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TPX2
    Official Full Name
    targeting protein for XKLP2
    Primary source
    TAIR:AT1G03780
    Locus tag
    AT1G03780
    See related
    Araport:AT1G03780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtTPX2; F21M11.31; F21M11_31; targeting protein for XKLP2
    Summary
    Homolog of vertebrate TPX2. Protein has three domains involved in nuclear targeting, one in nuclear export and two in microtubule binding. Involved in mitotic spindle assembly during late prophase and early prometaphase.
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    Genomic context

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    See TPX2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    17
    Sequence:
    Chromosome: 1; NC_003070.9 (947520..951850, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene switch 2 Neighboring gene Prefoldin chaperone subunit family protein Neighboring gene RING 1B Neighboring gene Zinc finger C-x8-C-x5-C-x3-H type family protein Neighboring gene ERF domain protein 10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aberrant microtubule organization in dividing root cells of p60-katanin mutants. Panteris E, et al. Plant Signal Behav, 2012 Jan. PMID 22301959, Free PMC Article
    2. The plant TPX2 protein regulates prospindle assembly before nuclear envelope breakdown. Vos JW, et al. Plant Cell, 2008 Oct. PMID 18941054, Free PMC Article
    3. Overexpressed TPX2 causes ectopic formation of microtubular arrays in the nuclei of acentrosomal plant cells. Petrovská B, et al. J Exp Bot, 2013 Nov. PMID 24006426, Free PMC Article
    4. Plant Aurora kinases play a role in maintenance of primary meristems and control of endoreduplication. Petrovská B, et al. New Phytol, 2012 Feb. PMID 22150830
    5. Functional Divergence of Microtubule-Associated TPX2 Family Members in Arabidopsis thaliana. Dvořák Tomaštíková E, et al. Int J Mol Sci, 2020 Mar 22. PMID 32235723, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional Divergence of Microtubule-Associated TPX2 Family Members in Arabidopsis thaliana.
      Title: Functional Divergence of Microtubule-Associated TPX2 Family Members in Arabidopsis thaliana.
    2. Overexpressed AtTPX2 reinforces microtubule formation in the vicinity of chromatin and the nuclear envelope.
      Title: Overexpressed TPX2 causes ectopic formation of microtubular arrays in the nuclei of acentrosomal plant cells.
    3. show that the Targeting Protein for Xklp2 (TPX2) protein co-localizes with microtubules on the surface of prophase nuclei of the mutants, probably participating in multipolar spindle assembly
      Title: Aberrant microtubule organization in dividing root cells of p60-katanin mutants.
    4. TPX2 is localized to the cell nucleus and microtubules, and has a role in proper spindle assembly.
      Title: The plant TPX2 protein regulates prospindle assembly before nuclear envelope breakdown.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_100257.3
    NM_202025.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast envelope HDA PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in phragmoplast IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in spindle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    targeting protein for XKLP2
    NP_001184902.1
    • targeting protein for XKLP2 (TPX2); FUNCTIONS IN: microtubule binding; INVOLVED IN: spindle assembly; LOCATED IN: nucleus; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Cell cycle regulated microtubule associated protein (InterPro:IPR022021), Xklp2 targeting protein (InterPro:IPR009675); BEST Arabidopsis thaliana protein match is: TPX2 (targeting protein for Xklp2) protein family (TAIR:AT5G44270.1).
    NP_171874.3
    • targeting protein for XKLP2 (TPX2); FUNCTIONS IN: microtubule binding; INVOLVED IN: spindle assembly; LOCATED IN: nucleus, chloroplast envelope; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Cell cycle regulated microtubule associated protein (InterPro:IPR022021); BEST Arabidopsis thaliana protein match is: Cell cycle regulated microtubule associated protein (TAIR:AT4G22860.2); Has 864 Blast hits to 721 proteins in 133 species: Archae - 2; Bacteria - 40; Metazoa - 457; Fungi - 40; Plants - 113; Viruses - 0; Other Eukaryotes - 212 (source: NCBI BLink).
    NP_973754.2
    • targeting protein for XKLP2 (TPX2); CONTAINS InterPro DOMAIN/s: Cell cycle regulated microtubule associated protein (InterPro:IPR022021), Xklp2 targeting protein (InterPro:IPR009675); BEST Arabidopsis thaliana protein match is: TPX2 (targeting protein for Xklp2) protein family (TAIR:AT5G44270.1); Has 2017 Blast hits to 1530 proteins in 221 species: Archae - 5; Bacteria - 108; Metazoa - 882; Fungi - 144; Plants - 344; Viruses - 0; Other Eukaryotes - 534 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      947520..951850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001197973.1 → NP_001184902.1  targeting protein for XKLP2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001184902.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I2H7, F4I2H9, Q3EDJ2, Q56XS5, Q9ZWA0
      Conserved Domains (2) summary
      pfam06886
      Location:652 → 705
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam12214
      Location:315 → 487
      TPX2_importin; Cell cycle regulated microtubule associated protein

    2. NM_202025.3 → NP_973754.2  targeting protein for XKLP2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973754.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WE47, A0A5S9SFC0
      Conserved Domains (2) summary
      pfam06886
      Location:647 → 728
      TPX2; Targeting protein for Xklp2 (TPX2)
      pfam12214
      Location:320 → 487
      TPX2_importin; Cell cycle regulated microtubule associated protein

    3. NM_100257.3 → NP_171874.3  targeting protein for XKLP2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171874.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I2H7
      Conserved Domains (1) summary
      pfam12214
      Location:315 → 466
      TPX2_importin; Cell cycle regulated microtubule associated protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4I2H7.1

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