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    UGT74B1 UDP-glucosyl transferase 74B1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839022, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UGT74B1
    Official Full Name
    UDP-glucosyl transferase 74B1
    Primary source
    TAIR:AT1G24100
    Locus tag
    AT1G24100
    See related
    Araport:AT1G24100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F3I6.2; F3I6_2; UDP-glucosyl transferase 74B1
    Summary
    Encodes a UDP-glucose:thiohydroximate S-glucosyltransferase, involved in glucosinolate biosynthesis
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    Genomic context

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    See UGT74B1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (8525334..8527087, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Putative thiol-disulfide oxidoreductase DCC Neighboring gene ncRNA Neighboring gene Peroxidase superfamily protein Neighboring gene ARG1-like 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kinetic analysis of Arabidopsis glucosyltransferase UGT74B1 illustrates a general mechanism by which enzymes can escape product inhibition. Kopycki J, et al. Biochem J, 2013 Feb 15. PMID 23150922
    2. Arabidopsis glucosyltransferase UGT74B1 functions in glucosinolate biosynthesis and auxin homeostasis. Grubb CD, et al. Plant J, 2004 Dec. PMID 15584955
    3. Glucosinolate metabolites required for an Arabidopsis innate immune response. Clay NK, et al. Science, 2009 Jan 2. PMID 19095898, Free PMC Article
    4. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kinetic analysis of Arabidopsis glucosyltransferase UGT74B1 illustrates a general mechanism by which enzymes can escape product inhibition.
      Title: Kinetic analysis of Arabidopsis glucosyltransferase UGT74B1 illustrates a general mechanism by which enzymes can escape product inhibition.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_102256.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables thiohydroximate beta-D-glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thiohydroximate beta-D-glucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response by callose deposition in cell wall IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glucosinolate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucosyl transferase 74B1
    NP_173820.1
    • UDP-glucosyl transferase 74B1 (UGT74B1); CONTAINS InterPro DOMAIN/s: UDP-glucuronosyl/UDP-glucosyltransferase (InterPro:IPR002213); BEST Arabidopsis thaliana protein match is: UDP-glycosyltransferase 74 F1 (TAIR:AT2G43840.1); Has 7754 Blast hits to 7677 proteins in 493 species: Archae - 0; Bacteria - 488; Metazoa - 2030; Fungi - 39; Plants - 5027; Viruses - 105; Other Eukaryotes - 65 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      8525334..8527087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102256.3 → NP_173820.1  UDP-glucosyl transferase 74B1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173820.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48676, Q0WLE1, W8PVB1
      UniProtKB/TrEMBL
      A0A178WKT6, A0A5S9VTH6
      Conserved Domains (1) summary
      cl10013
      Location:7 → 455
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O48676.1

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