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    MTR4 RNA helicase, ATP-dependent, SK12/DOB1 protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842269, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MTR4
    Official Full Name
    RNA helicase, ATP-dependent, SK12/DOB1 protein
    Primary source
    TAIR:AT1G59760
    Locus tag
    AT1G59760
    See related
    Araport:AT1G59760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtMTR4; F23H11.8; F23H11_8; homolog of yeast MTR4
    Summary
    Encodes MTR4, a putative RNA helicase and exosome co-factor. Required for proper rRNA biogenesis and development.
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    Genomic context

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    See MTR4 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Sequence:
    Chromosome: 1; NC_003070.9 (21984428..21990286, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene thioredoxin H-type 7 Neighboring gene Major facilitator superfamily protein Neighboring gene auxin response factor 1 Neighboring gene pseudo Neighboring gene NB-ARC domain-containing disease resistance protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MTR4, a putative RNA helicase and exosome co-factor, is required for proper rRNA biogenesis and development in Arabidopsis thaliana. Lange H, et al. Plant J, 2011 Oct. PMID 21682783
    2. The RNA helicases AtMTR4 and HEN2 target specific subsets of nuclear transcripts for degradation by the nuclear exosome in Arabidopsis thaliana. Lange H, et al. PLoS Genet, 2014 Aug. PMID 25144737, Free PMC Article
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We show that the Arabidopsis core exosome can associate with two related RNA helicases, AtMTR4 and HEN2
      Title: The RNA helicases AtMTR4 and HEN2 target specific subsets of nuclear transcripts for degradation by the nuclear exosome in Arabidopsis thaliana.
    2. AtMTR4 is involved in rRNA biogenesis and development in Arabidopsis. [AtMTR4]
      Title: MTR4, a putative RNA helicase and exosome co-factor, is required for proper rRNA biogenesis and development in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_104669.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within rRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RNA helicase, ATP-dependent, SK12/DOB1 protein
    NP_176185.1
    • RNA helicase, ATP-dependent, SK12/DOB1 protein; FUNCTIONS IN: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, helicase activity, ATP binding, ATP-dependent helicase activity, nucleic acid binding; INVOLVED IN: N-terminal protein myristoylation; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), DSH, C-terminal (InterPro:IPR012961), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), RNA helicase, ATP-dependent, SK12/DOB1 (InterPro:IPR016438), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: RNA helicase, ATP-dependent, SK12/DOB1 protein (TAIR:AT2G06990.1); Has 9909 Blast hits to 8438 proteins in 1290 species: Archae - 828; Bacteria - 3072; Metazoa - 1170; Fungi - 1231; Plants - 476; Viruses - 32; Other Eukaryotes - 3100 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      21984428..21990286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104669.4 → NP_176185.1  RNA helicase, ATP-dependent, SK12/DOB1 protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176185.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XIF2
      UniProtKB/TrEMBL
      A0A178W5A1, A0A5S9WQP6, A0A654EKU7
      Conserved Domains (1) summary
      COG4581
      Location:40 → 988
      Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XIF2.1

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