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    KCS6 3-ketoacyl-CoA synthase 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843182, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KCS6
    Official Full Name
    3-ketoacyl-CoA synthase 6
    Primary source
    TAIR:AT1G68530
    Locus tag
    AT1G68530
    See related
    Araport:AT1G68530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    3-ketoacyl-CoA synthase 6; AtCUT1; CER6; CUT1; CUTICULAR 1; ECERIFERUM 6; G2; POLLEN-PISTIL INCOMPATIBILITY 1; POP1; T26J14.10; T26J14_10
    Summary
    Encodes KCS6, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids).
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    Genomic context

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    See KCS6 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (25712414..25715024, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene LOB domain-containing protein 42 Neighboring gene B-box type zinc finger protein with CCT domain-containing protein Neighboring gene uncharacterized protein Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene Integrase-type DNA-binding superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary conserved function of barley and Arabidopsis 3-KETOACYL-CoA SYNTHASES in providing wax signals for germination of powdery mildew fungi. Weidenbach D, et al. Plant Physiol, 2014 Nov. PMID 25201879, Free PMC Article
    2. Composition of alkyl esters in the cuticular wax on inflorescence stems of Arabidopsis thaliana cer mutants. Lai C, et al. Plant J, 2007 Apr. PMID 17376164
    3. CUT1, an Arabidopsis gene required for cuticular wax biosynthesis and pollen fertility, encodes a very-long-chain fatty acid condensing enzyme. Millar AA, et al. Plant Cell, 1999 May. PMID 10330468, Free PMC Article
    4. The VLCFA elongase gene family in Arabidopsis thaliana: phylogenetic analysis, 3D modelling and expression profiling. Joubès J, et al. Plant Mol Biol, 2008 Jul. PMID 18465198
    5. Saturated very-long-chain fatty acids promote cotton fiber and Arabidopsis cell elongation by activating ethylene biosynthesis. Qin YM, et al. Plant Cell, 2007 Nov. PMID 17993622, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CUT1 is providing wax signals for germination of powdery mildew fungi on Arabidopsis.
      Title: Evolutionary conserved function of barley and Arabidopsis 3-KETOACYL-CoA SYNTHASES in providing wax signals for germination of powdery mildew fungi.
    2. Results show that alcohol levels at the site of biosynthesis are mainly limiting the ester formation in the Arabidopsis CER6 wild-type epidermis.
      Title: Composition of alkyl esters in the cuticular wax on inflorescence stems of Arabidopsis thaliana cer mutants.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    • At1g68530_Arabidopsis_lyrata_ssp._lyrata_CAN1 (e-PCR)
    • At1g68530_Arabidopsis_lyrata_ssp._petraea_GER1 (e-PCR)

    Homology

    NM_105524.3
    NM_179530.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables fatty acid elongase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cutin-based cuticle development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within very long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within wax biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    3-ketoacyl-CoA synthase 6
    NP_177020.1
    • 3-ketoacyl-CoA synthase 6 (KCS6); FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, catalytic activity; INVOLVED IN: in 7 processes; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase-like (InterPro:IPR016039), Very-long-chain 3-ketoacyl-CoA synthase (InterPro:IPR012392), 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal (InterPro:IPR013747), FAE1/Type III polyketide synthase-like protein (InterPro:IPR013601), Thiolase-like, subgroup (InterPro:IPR016038); BEST Arabidopsis thaliana protein match is: 3-ketoacyl-CoA synthase 5 (TAIR:AT1G25450.1); Has 4523 Blast hits to 4503 proteins in 1079 species: Archae - 0; Bacteria - 1483; Metazoa - 0; Fungi - 25; Plants - 2866; Viruses - 0; Other Eukaryotes - 149 (source: NCBI BLink).
    NP_849861.1
    • 3-ketoacyl-CoA synthase 6 (KCS6); FUNCTIONS IN: transferase activity, transferring acyl groups other than amino-acyl groups, catalytic activity; INVOLVED IN: in 7 processes; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thiolase-like (InterPro:IPR016039), FAE1/Type III polyketide synthase-like protein (InterPro:IPR013601), Thiolase-like, subgroup (InterPro:IPR016038); BEST Arabidopsis thaliana protein match is: 3-ketoacyl-CoA synthase 5 (TAIR:AT1G25450.1); Has 1620 Blast hits to 1616 proteins in 389 species: Archae - 0; Bacteria - 691; Metazoa - 0; Fungi - 0; Plants - 849; Viruses - 0; Other Eukaryotes - 80 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      25712414..25715024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105524.3 → NP_177020.1  3-ketoacyl-CoA synthase 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177020.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3ECG1, Q56ZC4, Q8VYJ5, Q9XF43
      UniProtKB/TrEMBL
      A0A178WCX7, A0A5S9WSQ9, Q8LAZ1
      Conserved Domains (1) summary
      PLN02377
      Location:6 → 489
      PLN02377; 3-ketoacyl-CoA synthase

    2. NM_179530.1 → NP_849861.1  3-ketoacyl-CoA synthase 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849861.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XF43
      Conserved Domains (1) summary
      pfam08392
      Location:81 → 349
      FAE1_CUT1_RppA; FAE1/Type III polyketide synthase-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XF43.1

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