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    ZDS zeta-carotene desaturase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819647, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ZDS
    Official Full Name
    zeta-carotene desaturase
    Primary source
    TAIR:AT3G04870
    Locus tag
    AT3G04870
    See related
    Araport:AT3G04870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    PDE181; PIGMENT DEFECTIVE EMBRYO 181; PRE ZETA-CAROTENE DESATURASE PRECURSOR; SPC1; SPONTANEOUS CELL DEATH 1; T9J14.18; zeta-carotene desaturase
    Summary
    Involved in the biosynthesis of carotenes and xanthophylls, reduces zeta-carotene to lycopene.
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    Genomic context

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    See ZDS in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Sequence:
    Chromosome: 3; NC_003074.8 (1342455..1346387)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene miscRNA Neighboring gene hypothetical protein (DUF868) Neighboring gene DNA-damage-repair/toleration protein (DRT102) Neighboring gene ncRNA Neighboring gene adenine phosphoribosyltransferase-like protein, putative (DUF2358) Neighboring gene Heavy metal transport/detoxification superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deregulation of ζ-carotene desaturase in Arabidopsis and tomato exposes a unique carotenoid-derived redundant regulation of floral meristem identity and function. McQuinn RP, et al. Plant J, 2023 May. PMID 36861314
    2. An Uncharacterized Apocarotenoid-Derived Signal Generated in ζ-Carotene Desaturase Mutants Regulates Leaf Development and the Expression of Chloroplast and Nuclear Genes in Arabidopsis. Avendaño-Vázquez AO, et al. Plant Cell, 2014 Jun. PMID 24907342, Free PMC Article
    3. The Arabidopsis Spontaneous Cell Death1 gene, encoding a zeta-carotene desaturase essential for carotenoid biosynthesis, is involved in chloroplast development, photoprotection and retrograde signalling. Dong H, et al. Cell Res, 2007 May. PMID 17468780
    4. Two Arabidopsis thaliana carotene desaturases, phytoene desaturase and zeta-carotene desaturase, expressed in Escherichia coli, catalyze a poly-cis pathway to yield pro-lycopene. Bartley GE, et al. Eur J Biochem, 1999 Jan. PMID 9914519
    5. Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. Froehlich JE, et al. J Proteome Res, 2003 Jul-Aug. PMID 12938931

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deregulation of zeta-carotene desaturase in Arabidopsis and tomato exposes a unique carotenoid-derived redundant regulation of floral meristem identity and function.
      Title: Deregulation of ζ-carotene desaturase in Arabidopsis and tomato exposes a unique carotenoid-derived redundant regulation of floral meristem identity and function.
    2. SPC1 encodes a putative zeta-carotene desaturase (ZDS) in the carotenoid biosynthesis pathway and plays a crucial role in plant growth and development [SPC1]
      Title: The Arabidopsis Spontaneous Cell Death1 gene, encoding a zeta-carotene desaturase essential for carotenoid biosynthesis, is involved in chloroplast development, photoprotection and retrograde signalling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001337544.1
    NM_001337545.1
    NM_111359.4
    NM_202493.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 9,9'-di-cis-zeta-carotene desaturase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 9,9'-di-cis-zeta-carotene desaturase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 9,9'-di-cis-zeta-carotene desaturation to 7,9,7',9'-tetra-cis-lycopene IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within carotene biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in carotenoid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lycopene biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 

    General protein information

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    Preferred Names
    zeta-carotene desaturase
    NP_001319473.1
    • zeta-carotene desaturase (ZDS); FUNCTIONS IN: carotene 7,8-desaturase activity; INVOLVED IN: carotene biosynthetic process; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Amine oxidase (InterPro:IPR002937), Adrenodoxin reductase (InterPro:IPR000759), Carotene 7,8-desaturase (InterPro:IPR014103); BEST Arabidopsis thaliana protein match is: phytoene desaturase 3 (TAIR:AT4G14210.1); Has 3641 Blast hits to 3625 proteins in 890 species: Archae - 42; Bacteria - 1934; Metazoa - 256; Fungi - 59; Plants - 443; Viruses - 2; Other Eukaryotes - 905 (source: NCBI BLink).
    NP_001319474.1
    • zeta-carotene desaturase (ZDS); FUNCTIONS IN: carotene 7,8-desaturase activity; INVOLVED IN: carotene biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Amine oxidase (InterPro:IPR002937), Adrenodoxin reductase (InterPro:IPR000759), Carotene 7,8-desaturase (InterPro:IPR014103); BEST Arabidopsis thaliana protein match is: phytoene desaturase 3 (TAIR:AT4G14210.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1342455..1346387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001337544.1 → NP_001319473.1  zeta-carotene desaturase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LPJ6, Q38893, Q8LD88, Q93YN2, Q9CAV3, Q9LLY1
      UniProtKB/TrEMBL
      A0A178VM60, A0A5S9X938

    2. NM_001337545.1 → NP_001319474.1  zeta-carotene desaturase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LPJ6, Q38893, Q8LD88, Q93YN2, Q9CAV3, Q9LLY1
      UniProtKB/TrEMBL
      A0A178VM60, A0A5S9X938

    3. NM_111359.4 → NP_187138.1  zeta-carotene desaturase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187138.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LPJ6, Q38893, Q8LD88, Q93YN2, Q9CAV3, Q9LLY1
      UniProtKB/TrEMBL
      A0A178VM60, A0A5S9X938
      Conserved Domains (2) summary
      PLN02487
      Location:1 → 550
      PLN02487; zeta-carotene desaturase
      pfam13450
      Location:61 → 127
      NAD_binding_8; NAD(P)-binding Rossmann-like domain

    4. NM_202493.3 → NP_974222.1  zeta-carotene desaturase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974222.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1I9LPJ6, Q38893, Q8LD88, Q93YN2, Q9CAV3, Q9LLY1
      UniProtKB/TrEMBL
      A0A178VM60, A0A5S9X938
      Conserved Domains (2) summary
      PLN02487
      Location:1 → 550
      PLN02487; zeta-carotene desaturase
      pfam13450
      Location:61 → 127
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38893.3

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