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    GTP cyclohydrolase I [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819915, updated on 18-Sep-2024

    Summary

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    Official Full Name
    GTP cyclohydrolase I
    Primary source
    TAIR:AT3G07270
    Locus tag
    AT3G07270
    See related
    Araport:AT3G07270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (2313998..2317364)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene nuclear transport factor 2/RNA recognition motif protein Neighboring gene SMAD/FHA domain-containing protein Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rice folate enhancement through metabolic engineering has an impact on rice seed metabolism, but does not affect the expression of the endogenous folate biosynthesis genes. Blancquaert D, et al. Plant Mol Biol, 2013 Nov. PMID 23771598
    2. Folate synthesis in plants: the first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I. Basset G, et al. Proc Natl Acad Sci U S A, 2002 Sep 17. PMID 12221287, Free PMC Article
    3. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The expression of both At-GTPCHI and At-ADCS is concordant with the accumulation of folate and its precursors in the developing transgenic rice seeds.
      Title: Rice folate enhancement through metabolic engineering has an impact on rice seed metabolism, but does not affect the expression of the endogenous folate biosynthesis genes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_111607.3
    NM_202517.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTP cyclohydrolase I activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP cyclohydrolase I activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in folic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tetrahydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    GTP cyclohydrolase I
    NP_187383.1
    • GTP cyclohydrolase I; CONTAINS InterPro DOMAIN/s: GTP cyclohydrolase I/Nitrile oxidoreductase (InterPro:IPR020602); Has 13749 Blast hits to 7133 proteins in 2143 species: Archae - 132; Bacteria - 8697; Metazoa - 425; Fungi - 313; Plants - 76; Viruses - 16; Other Eukaryotes - 4090 (source: NCBI BLink).
    NP_974246.1
    • GTP cyclohydrolase I; CONTAINS InterPro DOMAIN/s: GTP cyclohydrolase I/Nitrile oxidoreductase (InterPro:IPR020602); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2313998..2317364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202517.1 → NP_974246.1  GTP cyclohydrolase I [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974246.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EIV2, F4JED5
      Conserved Domains (2) summary
      PLN02531
      Location:1 → 460
      PLN02531; GTP cyclohydrolase I
      cl00263
      Location:270 → 450
      TFold; Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl ...

    2. NM_111607.3 → NP_187383.1  GTP cyclohydrolase I [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187383.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S3C2, Q9SFV7
      UniProtKB/TrEMBL
      A0A178VDP2, A0A5S9XA98, A0A7G2EIV2
      Conserved Domains (1) summary
      PLN02531
      Location:1 → 460
      PLN02531; GTP cyclohydrolase I
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SFV7.1

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