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    MSH7 MUTS homolog 7 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822040, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MSH7
    Official Full Name
    MUTS homolog 7
    Primary source
    TAIR:AT3G24495
    Locus tag
    AT3G24495
    See related
    Araport:AT3G24495
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA MUTS HOMOLOG 7; ATMSH7; MSH6-2; MUTS HOMOLOG 6-2; MUTS homolog 7
    Summary
    encodes a DNA mismatch repair homolog of human MutS gene, MSH6. There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2*MSH7 exhibit moderate affinity for a (T/G) substrate and weak binding of (+T), suggesting MSH2*MSH7 may be specialized for lesions/base mispairs not tested or for (T/G) mispairs in special contexts.
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    Genomic context

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    See MSH7 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    17
    Sequence:
    Chromosome: 3; NC_003074.8 (8912343..8918288, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat (LRR) family protein Neighboring gene Alcohol dehydrogenase transcription factor Myb/SANT-like family protein Neighboring gene ncRNA Neighboring gene multiprotein bridging factor 1C Neighboring gene aldehyde dehydrogenase 2C4 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of the mismatch repair protein MSH7 in Arabidopsis adaptation to acute salt stress. Chirinos-Arias MC, et al. Plant Physiol Biochem, 2021 Dec. PMID 34823145
    2. Role of AtMSH7 in UV-B-induced DNA damage recognition and recombination. Lario LD, et al. J Exp Bot, 2015 Jun. PMID 25465032
    3. Mismatch recognition function of Arabidopsis thaliana MutSγ. Gómez R, et al. DNA Repair (Amst), 2013 Apr 1. PMID 23380521
    4. Arabidopsis MutS homologs-AtMSH2, AtMSH3, AtMSH6, and a novel AtMSH7-form three distinct protein heterodimers with different specificities for mismatched DNA. Culligan KM, et al. Plant Cell, 2000 Jun. PMID 10852942, Free PMC Article
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_180299.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MUTS homolog 7
    NP_850630.1
    • MUTS homolog 7 (MSH7); FUNCTIONS IN: damaged DNA binding, mismatched DNA binding, ATP binding; INVOLVED IN: mismatch repair; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein MutS, connector (InterPro:IPR007860), DNA mismatch repair protein MutS, N-terminal (InterPro:IPR016151), DNA mismatch repair protein MutS, core (InterPro:IPR007696), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS-homologue MSH6 (InterPro:IPR015536), DNA mismatch repair protein MutS-like, N-terminal (InterPro:IPR007695); BEST Arabidopsis thaliana protein match is: MUTS homolog 6 (TAIR:AT4G02070.2); Has 17871 Blast hits to 13835 proteins in 2667 species: Archae - 197; Bacteria - 11731; Metazoa - 1028; Fungi - 1274; Plants - 566; Viruses - 3; Other Eukaryotes - 3072 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      8912343..8918288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001338685.1 → NP_001326470.1  MUTS homolog 7 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LPD3

    2. NM_180299.1 → NP_850630.1  MUTS homolog 7 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850630.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22372, Q9SMV7, Q9SNZ4
      UniProtKB/TrEMBL
      A0A654FC73
      Conserved Domains (5) summary
      cd03286
      Location:810 → 1038
      ABC_MSH6_euk; ATP-binding cassette domain of eukaryotic MutS6 homolog
      COG0249
      Location:264 → 1070
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
      pfam01624
      Location:271 → 382
      MutS_I; MutS domain I
      pfam05188
      Location:389 → 540
      MutS_II; MutS domain II
      pfam05192
      Location:558 → 776
      MutS_III; MutS domain III
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SMV7.1

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