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    ABCI15 trigalactosyldiacylglycerol2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821576, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ABCI15
    Official Full Name
    trigalactosyldiacylglycerol2
    Primary source
    TAIR:AT3G20320
    Locus tag
    AT3G20320
    See related
    Araport:AT3G20320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATP-binding cassette I15; TGD2; trigalactosyldiacylglycerol2
    Summary
    Encodes a permease-like component of an ABC transporter involved in lipid transfer from ER to chloroplast. A phosphatidic acid-binding protein with a predicted mycobacterial cell entry domain. It is tethered to the inner chloroplast envelope membrane facing the outer envelope membrane. Presumed bacterial orthologs of TGD1 and TGD2 in Gram-negative bacteria are typically organized in transcriptional units, suggesting their involvement in a common biological process. Mutations in this gene suppress the low temperature-induced phenotype of Arabidopsis tocopherol-deficient mutant vte2.
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    Genomic context

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    See ABCI15 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (7087445..7089927, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene extracellular ligand-gated ion channel protein (DUF3537) Neighboring gene ethylene response factor 7 Neighboring gene PYRIMIDINE B Neighboring gene protein expression protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis chloroplast lipid transport protein TGD2 disrupts membranes and is part of a large complex. Roston R, et al. Plant J, 2011 Jun. PMID 21309871
    2. A phosphatidic acid-binding protein of the chloroplast inner envelope membrane involved in lipid trafficking. Awai K, et al. Proc Natl Acad Sci U S A, 2006 Jul 11. PMID 16818883, Free PMC Article
    3. TGD1, -2, and -3 proteins involved in lipid trafficking form ATP-binding cassette (ABC) transporter with multiple substrate-binding proteins. Roston RL, et al. J Biol Chem, 2012 Jun 15. PMID 22544736, Free PMC Article
    4. A small ATPase protein of Arabidopsis, TGD3, involved in chloroplast lipid import. Lu B, et al. J Biol Chem, 2007 Dec 7. PMID 17938172
    5. Arabidopsis TRIGALACTOSYLDIACYLGLYCEROL5 Interacts with TGD1, TGD2, and TGD4 to Facilitate Lipid Transfer from the Endoplasmic Reticulum to Plastids. Fan J, et al. Plant Cell, 2015 Oct. PMID 26410300, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TGD1, -2, and -3 proteins involved in lipid trafficking form ATP-binding cassette (ABC) transporter with multiple substrate-binding proteins.
      Title: TGD1, -2, and -3 proteins involved in lipid trafficking form ATP-binding cassette (ABC) transporter with multiple substrate-binding proteins.
    2. TGD2 is part of a protein complex larger than 500 kDa, the formation of which is disrupted in two mutant alleles, indicative of the biological relevance of this TGD2-containing complex.
      Title: Arabidopsis chloroplast lipid transport protein TGD2 disrupts membranes and is part of a large complex.
    3. TGD3 is the missing ATPase component of a lipid transporter involving TGD1 and TGD2 required for the biosynthesis of ER-derived thylakoid lipids in Arabidopsis.
      Title: A small ATPase protein of Arabidopsis, TGD3, involved in chloroplast lipid import.
    4. This protein is identical to Arabidopsis gene TRIGALACTOSYLDIACYLGLYCEROL 2 (TGD2).
      Title: A phosphatidic acid-binding protein of the chloroplast inner envelope membrane involved in lipid trafficking.
    5. TGD2 (TRIGALACTOSYLDIACYLGLYCEROL 2) gene represents the substrate-binding or regulatory component of a phosphatidic acid/lipid transport complex in the chloroplast inner envelope membrane. (TGD2)
      Title: A phosphatidic acid-binding protein of the chloroplast inner envelope membrane involved in lipid trafficking.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001338475.1
    NM_112923.4
    NM_202616.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables lipid transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular lipid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    trigalactosyldiacylglycerol2
    NP_001319601.1
    • trigalactosyldiacylglycerol2 (TGD2); FUNCTIONS IN: phospholipid binding, lipid transporter activity; INVOLVED IN: lipid transport; LOCATED IN: chloroplast, chloroplast inner membrane, chloroplast envelope, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Mammalian cell entry related (InterPro:IPR003399); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_566659.1
    • trigalactosyldiacylglycerol2 (TGD2); FUNCTIONS IN: phospholipid binding, lipid transporter activity; INVOLVED IN: lipid transport; LOCATED IN: chloroplast, chloroplast inner membrane, membrane, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Mammalian cell entry related (InterPro:IPR003399); Has 660 Blast hits to 610 proteins in 215 species: Archae - 0; Bacteria - 436; Metazoa - 0; Fungi - 2; Plants - 56; Viruses - 0; Other Eukaryotes - 166 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7087445..7089927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112923.4 → NP_566659.1  trigalactosyldiacylglycerol2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566659.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EB35, Q8LDY9, Q9LTR2
      UniProtKB/TrEMBL
      A0A178V976, A0A5S9XEC5
      Conserved Domains (1) summary
      PLN03094
      Location:20 → 381
      PLN03094; Substrate binding subunit of ER-derived-lipid transporter; Provisional

    2. NM_001338475.1 → NP_001319601.1  trigalactosyldiacylglycerol2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LTR2
      Conserved Domains (1) summary
      PLN03094
      Location:20 → 282
      PLN03094; Substrate binding subunit of ER-derived-lipid transporter; Provisional

    3. NM_202616.1 → NP_974345.1  trigalactosyldiacylglycerol2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974345.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LTR2
      Conserved Domains (1) summary
      PLN03094
      Location:20 → 282
      PLN03094; Substrate binding subunit of ER-derived-lipid transporter; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LTR2.1

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