KAT2 potassium channel KAT1-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: KAT2
Official Full Name: potassium channel KAT1-like protein
Primary source: TAIR:AT4G18290
Locus tag: AT4G18290
See related: Araport:AT4G18290
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: potassium channel in Arabidopsis thaliana 2; T9A21.140; T9A21_140; VOLTAGE-GATED POTASSIUM CHANNEL 2
Summary: Encodes KAT2, a member of the Shaker family potassium ion (K+) channel. Critical to stomatal opening induced by blue light. Critical to circadian rhythm of stomatal opening. Involved in plant development in response to high light intensity. Under high light intensity, the mutant plant produced less biomass compared to the wild type. The Shaker family K+ ion channels include five groups based on phylogenetic analysis (FEBS Letters (2007) 581: 2357): I (inward rectifying channel): AKT1 (AT2G26650), AKT5 (AT4G32500) and SPIK (also known as AKT6, AT2G25600); II (inward rectifying channel): KAT1 (AT5G46240) and KAT2 (AT4G18290); III (weakly inward rectifying channel): AKT2 (AT4G22200); IV (regulatory subunit involved in inwardly rectifying conductance formation): KAT3 (also known as AtKC1, AT4G32650); V (outward rectifying channel): SKOR (AT3G02850) and GORK (AT5G37500).
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Genomic context

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See KAT2 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 11

Sequence:: Chromosome: 4; NC_003075.7 (10114794..10118652)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ca(2+)-Dependent Protein Kinase 6 Enhances KAT2 Shaker Channel Activity in Arabidopsis thaliana.
Title: Ca(2+)-Dependent Protein Kinase 6 Enhances KAT2 Shaker Channel Activity in Arabidopsis thaliana.
The Arabidopsis K(+) channel KAT1 complements in K(+)-limited medium the growth of the K(+) uptake defective Saccharomyces cerevisiae mutant strain CY162, while another K(+) channel, AKT2, does not.
Title: Identification of regions responsible for the function of the plant K(+) channels KAT1 and AKT2 in Saccharomyces cerevisiae and Xenopus laevis oocytes.
CPK13 reduces stomatal aperture through its inhibition of the guard cell-expressed KAT2 and KAT1 channels.
Title: CPK13, a noncanonical Ca2+-dependent protein kinase, specifically inhibits KAT2 and KAT1 shaker K+ channels and reduces stomatal opening.
The nine-amino acid stretch 312TVRAASEFA320 that composes the first C-linker alpha-helix located just below the pore is a crucial determinant of KAT2 channel activity.
Title: Distinct amino acids in the C-linker domain of the Arabidopsis K+ channel KAT2 determine its subcellular localization and activity at the plasma membrane.
KAT2 contributes to the synthesis of substituted hydroxybenzoylcholines.KAT2 plays the primary role in benzoic acid synthesis.
Title: Peroxisomal ATP-binding cassette transporter COMATOSE and the multifunctional protein abnormal INFLORESCENCE MERISTEM are required for the production of benzoylated metabolites in Arabidopsis seeds.
KAT2 was able to re-locate AtKC1 fused to GFP from endomembranes to the plasma membrane, indicating that heteromeric AtKC1-KAT2 channels are efficiently targeted to the plasma membrane.
Title: AtKC1 is a general modulator of Arabidopsis inward Shaker channel activity.
KAT2 may function downstream of an important WRKY transcription repressor WRKY40, which may link KAT2 with the ABA receptor ABAR/CHLH-mediated signaling.
Title: Arabidopsis 3-ketoacyl-CoA thiolase-2 (KAT2), an enzyme of fatty acid β-oxidation, is involved in ABA signal transduction.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_117939.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables inward rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables inward rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to high light intensity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stomatal movement	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: potassium channel KAT1-like protein

NP_193563.3

potassium channel in Arabidopsis thaliana 2 (KAT2); FUNCTIONS IN: inward rectifier potassium channel activity, cyclic nucleotide binding; INVOLVED IN: response to high light intensity, circadian rhythm, stomatal movement; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Ion transport (InterPro:IPR005821), Cyclic nucleotide-binding-like (InterPro:IPR018490), Potassium channel, voltage-dependent, EAG/ELK/ERG (InterPro:IPR003938), RmlC-like jelly roll fold (InterPro:IPR014710), Protein of unknown function DUF3354 (InterPro:IPR021789); BEST Arabidopsis thaliana protein match is: potassium channel in Arabidopsis thaliana 1 (TAIR:AT5G46240.1); Has 5076 Blast hits to 4706 proteins in 358 species: Archae - 8; Bacteria - 372; Metazoa - 1790; Fungi - 37; Plants - 1121; Viruses - 0; Other Eukaryotes - 1748 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

10114794..10118652

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001341273.1 → NP_001329801.1 potassium channel KAT1-like protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B8U1, A0A5S9XTZ2
NM_117939.5 → NP_193563.3 potassium channel KAT1-like protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O49732, Q38849, Q9C5V9

UniProtKB/TrEMBL

A0A5S9XTZ2, A0A654FQH6

Conserved Domains (1) summary

PLN03192
Location:16 → 697

PLN03192; Voltage-dependent potassium channel; Provisional