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    CYP707A1 cytochrome P450, family 707, subfamily A, polypeptide 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827663, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP707A1
    Official Full Name
    cytochrome P450, family 707, subfamily A, polypeptide 1
    Primary source
    TAIR:AT4G19230
    Locus tag
    AT4G19230
    See related
    Araport:AT4G19230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''cytochrome P450; cytochrome P450; family 707; polypeptide 1; polypeptide 1''; subfamily A; T18B16.200; T18B16_200
    Summary
    Encodes a protein with ABA 8'-hydroxylase activity, involved in ABA catabolism. Member of the CYP707A gene family. CYP707A1 appears to play an important role in determining the ABA levels in dry seeds. Gene involved in postgermination growth. Overexpression of CYP707A1 leads to a decrease in ABA levels and a reduction in after-ripening period to break dormancy.
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    Genomic context

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    See CYP707A1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    7
    Sequence:
    Chromosome: 4; NC_003075.7 (10521259..10523961)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene RNAse l inhibitor protein 2 Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene miscRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High humidity induces abscisic acid 8'-hydroxylase in stomata and vasculature to regulate local and systemic abscisic acid responses in Arabidopsis. Okamoto M, et al. Plant Physiol, 2009 Feb. PMID 19036833, Free PMC Article
    2. CYP707A1 and CYP707A2, which encode abscisic acid 8'-hydroxylases, are indispensable for proper control of seed dormancy and germination in Arabidopsis. Okamoto M, et al. Plant Physiol, 2006 May. PMID 16543410, Free PMC Article
    3. Hypoxia reshapes Arabidopsis root architecture by integrating ERF-VII factor response and abscisic acid homoeostasis. Eysholdt-Derzsó E, et al. Plant Cell Environ, 2024 Aug. PMID 38616485
    4. Arabidopsis CYP707As encode (+)-abscisic acid 8'-hydroxylase, a key enzyme in the oxidative catabolism of abscisic acid. Saito S, et al. Plant Physiol, 2004 Apr. PMID 15064374, Free PMC Article
    5. Seed dormancy and ABA metabolism in Arabidopsis and barley: the role of ABA 8'-hydroxylase. Millar AA, et al. Plant J, 2006 Mar. PMID 16507085

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CYP707A1 inactivates local abscisic acid pools inside the guard cells of Arabidopsis.
      Title: High humidity induces abscisic acid 8'-hydroxylase in stomata and vasculature to regulate local and systemic abscisic acid responses in Arabidopsis.
    2. CYP707A1 is expressed in Arabidopsis seeds predominantly during mid-maturation and is down-regulated during late-maturation and plays a distinct role in seed development and postgermination growth.
      Title: CYP707A1 and CYP707A2, which encode abscisic acid 8'-hydroxylases, are indispensable for proper control of seed dormancy and germination in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_118043.2
    NM_202845.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables (+)-abscisic acid 8'-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within release of seed from dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to red or far red light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 707, subfamily A, polypeptide 1
    NP_567581.1
    • ''cytochrome P450, family 707, subfamily A, polypeptide 1'' (CYP707A1); FUNCTIONS IN: oxygen binding, (+)-abscisic acid 8'-hydroxylase activity; INVOLVED IN: in 7 processes; LOCATED IN: endomembrane system; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 707, subfamily A, polypeptide 3 (TAIR:AT5G45340.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_974574.1
    • ''cytochrome P450, family 707, subfamily A, polypeptide 1'' (CYP707A1); FUNCTIONS IN: oxygen binding, (+)-abscisic acid 8'-hydroxylase activity; INVOLVED IN: in 7 processes; LOCATED IN: endomembrane system; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 707, subfamily A, polypeptide 3 (TAIR:AT5G45340.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      10521259..10523961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118043.2 → NP_567581.1  cytochrome P450, family 707, subfamily A, polypeptide 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567581.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65624, Q949P1
      UniProtKB/TrEMBL
      A0A178V0Q6, A0A5S9XTX9, A0A7G2F3V2
      Conserved Domains (1) summary
      PLN02196
      Location:1 → 463
      PLN02196; abscisic acid 8'-hydroxylase

    2. NM_202845.1 → NP_974574.1  cytochrome P450, family 707, subfamily A, polypeptide 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974574.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F3V2, A8MRX5
      Conserved Domains (1) summary
      PLN02196
      Location:1 → 464
      PLN02196; abscisic acid 8'-hydroxylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q949P1.1

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