FKD1 FORKED 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: FKD1
Official Full Name: FORKED 1
Primary source: TAIR:AT3G63300
Locus tag: AT3G63300
See related: Araport:AT3G63300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: FORKED 1; MAA21.9
Summary: Encodes a pleckstrin homology domain- and DUF828-containing protein. Mutants have defects in leaf vascular pattering, with vascular bundles that fail to meet distally in both the cotyledons and leaves. Necessary to the formation of the closed leaf vascular pattern characteristic of dicot leaves in response to auxin. Redundant with FKD2. FKD1 may influence PIN1 localization in an auxin dependent manner. proposed to be a key component of the auxin canalization pathway.
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Genomic context

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See FKD1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 5

Sequence:: Chromosome: 3; NC_003074.8 (23384988..23387842)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FKD1 and SFC co-localize with members of the RABA group of RAB-GTPases, which are proposed to act in the post-Golgi secretory pathway. The compartments labeled by FKD1 and SFC do not localize to membrane compartments induced by the fungal toxin brefeldin A.
Title: Localization of Arabidopsis FORKED1 to a RABA-positive compartment suggests a role in secretion.
Data suggest that FKD1 influences PIN1 localization in an auxin-dependent manner, and that it represents a key component of the auxin canalization pathway. [FKD1]
Title: FORKED1 encodes a PH domain protein that is required for PIN1 localization in developing leaf veins.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001340199.1

Supported by ESTs:

NM_116195.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within auxin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leaf vascular tissue pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phloem or xylem histogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-Golgi vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to auxin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within signal transduction	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in nucleus	ISM Inferred from Sequence Model more info
colocalizes_with trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: FORKED 1

NP_001319826.1

FORKED 1 (FKD1); CONTAINS InterPro DOMAIN/s: Pleckstrin-like, plant (InterPro:IPR013666), Protein of unknown function DUF828 (InterPro:IPR008546); BEST Arabidopsis thaliana protein match is: Plant protein of unknown function (DUF828) with plant pleckstrin homology-like region (TAIR:AT3G22810.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_191889.2

FORKED 1 (FKD1); CONTAINS InterPro DOMAIN/s: Pleckstrin-like, plant (InterPro:IPR013666), Protein of unknown function DUF828 (InterPro:IPR008546); BEST Arabidopsis thaliana protein match is: Plant protein of unknown function (DUF828) with plant pleckstrin homology-like region (TAIR:AT3G22810.1); Has 742 Blast hits to 348 proteins in 78 species: Archae - 0; Bacteria - 118; Metazoa - 127; Fungi - 51; Plants - 226; Viruses - 0; Other Eukaryotes - 220 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

23384988..23387842

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001340199.1 → NP_001319826.1 FORKED 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

F4J0Y8
NM_116195.3 → NP_191889.2 FORKED 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_191889.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8W4K5, Q9M1W0

UniProtKB/TrEMBL

A0A178VL38, A0A5S9XNA2

Conserved Domains (2) summary

pfam05703
Location:30 → 336

Auxin_canalis; Auxin canalisation

pfam08458
Location:379 → 484

PH_2; Plant pleckstrin homology-like region