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    SLD5 DNA replication protein-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834960, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SLD5
    Official Full Name
    DNA replication protein-like protein
    Primary source
    TAIR:AT5G49010
    Locus tag
    AT5G49010
    See related
    Araport:AT5G49010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    EMB2812; EMBRYO DEFECTIVE 2812; K19E20.14; K19E20_14; SYNTHETIC LETHALITY WITH DPB11-1 5
    Summary
    Similar to the SLD5 component of GINS complex, which in other organism was shown to be involved in the initiation of DNA replication.
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    Genomic context

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    See SLD5 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (19866231..19868877)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene uncharacterized protein Neighboring gene protein arginine methyltransferase 4A Neighboring gene tRNA synthetase class I (I, L, M and V) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide analysis of the core DNA replication machinery in the higher plants Arabidopsis and rice. Shultz RW, et al. Plant Physiol, 2007 Aug. PMID 17556508, Free PMC Article
    2. Ctf4-related protein recruits LHP1-PRC2 to maintain H3K27me3 levels in dividing cells in Arabidopsis thaliana. Zhou Y, et al. Proc Natl Acad Sci U S A, 2017 May 2. PMID 28428341, Free PMC Article
    3. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001125927.2
    NM_124278.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication initiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GINS complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DNA replication protein-like protein
    NP_001119399.1
    • SYNTHETIC LETHALITY WITH DPB11-1 5 (SLD5); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: DNA-dependent DNA replication initiation; LOCATED IN: GINS complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: GINS complex, subunit Sld5 (InterPro:IPR008591), GINS complex (InterPro:IPR021151); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_199712.2
    • SYNTHETIC LETHALITY WITH DPB11-1 5 (SLD5); CONTAINS InterPro DOMAIN/s: GINS complex (InterPro:IPR021151), GINS complex, subunit Sld5 (InterPro:IPR008591); Has 338 Blast hits to 337 proteins in 171 species: Archae - 0; Bacteria - 0; Metazoa - 117; Fungi - 122; Plants - 54; Viruses - 0; Other Eukaryotes - 45 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19866231..19868877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001125927.2 → NP_001119399.1  DNA replication protein-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119399.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3H4Z5
      Conserved Domains (1) summary
      cd11711
      Location:21 → 139
      GINS_A_Sld5; Alpha-helical domain of GINS complex protein Sld5

    2. NM_124278.4 → NP_199712.2  DNA replication protein-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199712.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NQP5, Q9FI69
      UniProtKB/TrEMBL
      A0A178UAX9, A0A7G2FJ75
      Conserved Domains (2) summary
      cd11711
      Location:21 → 139
      GINS_A_Sld5; Alpha-helical domain of GINS complex protein Sld5
      pfam16922
      Location:165 → 220
      SLD5_C; DNA replication complex GINS protein SLD5 C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NQP5.1

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