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    NHX3 Na+/H+ (sodium hydrogen) exchanger 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835640, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NHX3
    Official Full Name
    Na+/H+ (sodium hydrogen) exchanger 3
    Primary source
    TAIR:AT5G55470
    Locus tag
    AT5G55470
    See related
    Araport:AT5G55470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA NA+/H+ (SODIUM HYDROGEN) EXCHANGER 3; ATNHX3; MTE17.18; MTE17_18; Na+/H+ (sodium hydrogen) exchanger 3
    Summary
    member of Sodium proton exchanger family
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    Genomic context

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    See NHX3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    15
    Sequence:
    Chromosome: 5; NC_003076.8 (22469245..22472706, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene ncRNA Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene ncRNA Neighboring gene SHV3-like 1 Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtNHX3 is a vacuolar K+/H+ antiporter required for low-potassium tolerance in Arabidopsis thaliana. Liu H, et al. Plant Cell Environ, 2010 Nov. PMID 20573049
    2. Identification of novel families of membrane proteins from the model plant Arabidopsis thaliana. Ward JM. Bioinformatics, 2001 Jun. PMID 11395435
    3. Cation Specificity of Vacuolar NHX-Type Cation/H(+) Antiporters. Bassil E, et al. Plant Physiol, 2019 Feb. PMID 30498025, Free PMC Article
    4. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NHX3 is involved in vacuolar Na+ transport and plant growth.
      Title: Cation Specificity of Vacuolar NHX-Type Cation/H(+) Antiporters.
    2. AtNHX3 is mainly vacuolar membrane localized, and is involved in mediating K+ compartmentalization and homeostasis in Arabidopsis.
      Title: AtNHX3 is a vacuolar K+/H+ antiporter required for low-potassium tolerance in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_124929.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables sodium ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables sodium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within potassium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of pH IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Na+/H+ (sodium hydrogen) exchanger 3
    NP_200358.1
    • Na+/H+ (sodium hydrogen) exchanger 3 (NHX3); CONTAINS InterPro DOMAIN/s: Na+/H+ exchanger, subfamily (InterPro:IPR004709), Cation/H+ exchanger, conserved region (InterPro:IPR018422), Cation/H+ exchanger (InterPro:IPR006153), Na+/H+ exchanger, isoforms 1-4, conserved region (InterPro:IPR018407); BEST Arabidopsis thaliana protein match is: sodium hydrogen exchanger 2 (TAIR:AT3G05030.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      22469245..22472706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124929.3 → NP_200358.1  Na+/H+ (sodium hydrogen) exchanger 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200358.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8S397, Q9FJ63
      UniProtKB/TrEMBL
      A0A178UM68, A0A5S9YEA2
      Conserved Domains (1) summary
      TIGR00840
      Location:23 → 444
      b_cpa1; sodium/hydrogen exchanger 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8S397.2

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