LFY floral meristem identity control protein LEAFY (LFY) [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: LFY
Official Full Name: floral meristem identity control protein LEAFY (LFY)
Primary source: TAIR:AT5G61850
Locus tag: AT5G61850
See related: Araport:AT5G61850
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: LEAFY; LEAFY 3; LFY3; MAC9.13; MAC9_13
Summary: Encodes transcriptional regulator that promotes the transition to flowering.Involved in floral meristem development. LFY is involved in the regulation of AP3 expression, and appears to bring the F-box protein UFO to the AP3 promoter. Amino acids 46-120 define a protein domain that mediates self-interaction.
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Genomic context

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See LFY in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 3

Sequence:: Chromosome: 5; NC_003076.8 (24844248..24846989)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LEAFY and APETALA1 down-regulate ZINC FINGER PROTEIN 1 and 8 to release their repression on class B and C floral homeotic genes.
Title: LEAFY and APETALA1 down-regulate ZINC FINGER PROTEIN 1 and 8 to release their repression on class B and C floral homeotic genes.
The LEAFY floral regulator displays pioneer transcription factor properties.
Title: The LEAFY floral regulator displays pioneer transcription factor properties.
LEAFY is a pioneer transcription factor and licenses cell reprogramming to floral fate.
Title: LEAFY is a pioneer transcription factor and licenses cell reprogramming to floral fate.
LFY activity is fully dependent on BOP2 as well as on CUL3A and B to regulate target genes such as APETALA1 and to induce ectopic flower formation.
Title: LEAFY activity is post-transcriptionally regulated by BLADE ON PETIOLE2 and CULLIN3 in Arabidopsis.
LFY and AP1 are conserved floral regulators that act nonredundantly in C. hirsuta, such that LFY has more obvious roles in floral and leaf development in C. hirsuta than in A. thaliana.
Title: Conservation vs divergence in LEAFY and APETALA1 functions between Arabidopsis thaliana and Cardamine hirsuta.
LFY and AP1/CAL act as part of an incoherent feed-forward loop, a network motif where two interconnected pathways or transcription factors act in opposite directions on a target gene, to control the establishment of a stable developmental program for the formation of flowers.
Title: Transcription Factor Interplay between LEAFY and APETALA1/CAULIFLOWER during Floral Initiation.
WRKY71 activity hastens flowering via the direct activation of FT and LFY.
Title: WRKY71 accelerates flowering via the direct activation of FLOWERING LOCUS T and LEAFY in Arabidopsis thaliana.
data suggest that transcriptional regulation of LFY at the chromatin level by PKL may at least partially account for the late-flowering phenotype of pkl mutants
Title: CHD3 chromatin-remodeling factor PICKLE regulates floral transition partially via modulating LEAFY expression at the chromatin level in Arabidopsis.
ANT and AIL6 directly induce LFY expression in response to auxin to promote the onset of flower formation.
Title: AINTEGUMENTA and AINTEGUMENTA-LIKE6/PLETHORA3 Induce LEAFY Expression in Response to Auxin to Promote the Onset of Flower Formation in Arabidopsis.
A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor.
Title: A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MASC_STS15529 (e-PCR)
- UniSTS:258807

Homology

Orthologs from OrthoDB

NM_125579.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within floral meristem determinacy	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within flower development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gibberellic acid mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within maintenance of inflorescence meristem identity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: floral meristem identity control protein LEAFY (LFY)

NP_200993.1

LEAFY (LFY); CONTAINS InterPro DOMAIN/s: Floricaula/leafy protein (InterPro:IPR002910); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

24844248..24846989

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001345500.1 → NP_001331273.1 floral meristem identity control protein LEAFY (LFY) [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BDB4, A0A654GE89

Conserved Domains (2) summary

pfam01698
Location:44 → 111

LFY_SAM; Floricaula / Leafy protein SAM domain

pfam17538
Location:227 → 391

C_LFY_FLO; DNA Binding Domain (C-terminal) Leafy/Floricaula
NM_125579.1 → NP_200993.1 floral meristem identity control protein LEAFY (LFY) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_200993.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0MFR2, Q00958, Q1PDG5, Q8LSH2, Q8LSH3

UniProtKB/TrEMBL

A0A023T4L8, A0A178U799, A0A384L7U0

Conserved Domains (2) summary

pfam01698
Location:44 → 111

LFY_SAM; Floricaula / Leafy protein SAM domain

pfam17538
Location:223 → 387

C_LFY_FLO; DNA Binding Domain (C-terminal) Leafy/Floricaula