FNR1 ferredoxin-NADP[+]-oxidoreductase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: FNR1
Official Full Name: ferredoxin-NADP[+]-oxidoreductase 1
Primary source: TAIR:AT5G66190
Locus tag: AT5G66190
See related: Araport:AT5G66190
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATLFNR1; ferredoxin-NADP(+)-oxidoreductase 1; FERREDOXIN:NADP(H) OXIDOREDUCTASE; K2A18.27; K2A18_27; LEAF FNR 1; leaf-type chloroplast-targeted FNR 1; LFNR1
Summary: Encodes a leaf-type ferredoxin:NADP(H) oxidoreductase. It is present in both chloroplast stroma and thylakoid membranes but is more abundant in the thylakoid. The affinity of this enzyme for ferredoxin is slightly, but significantly, higher than AtLFNR2, an isoform of the same enzyme. AtLFNR1 forms a heterodimer with AtFNR2 and is also a prerequisite to attach AtFNR2 to the thylakoid membrane.
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Genomic context

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See FNR1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 9

Sequence:: Chromosome: 5; NC_003076.8 (26450964..26453199, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of photosynthetic electron flow on dark to light transition by ferredoxin:NADP(H) oxidoreductase interactions.
Title: Regulation of photosynthetic electron flow on dark to light transition by ferredoxin:NADP(H) oxidoreductase interactions.
fnr1 knock-outs, the NADP(H) and glutathione pools are more oxidized relative to the wild type, and the photoprotective effect is absent despite perception of oxidative stress at the level of gene transcription.
Title: Ferredoxin:NADP(H) Oxidoreductase Abundance and Location Influences Redox Poise and Stress Tolerance.
critical player in nitrogen-regulated flowering time
Title: Arabidopsis cryptochrome 1 functions in nitrogen regulation of flowering.
The dynamic, multilayer regulation of AtFNR exemplifies the complex regulatory network systems controlling chloroplast proteins by a range of posttranslational modifications.
Title: Posttranslational modifications of FERREDOXIN-NADP+ OXIDOREDUCTASE in Arabidopsis chloroplasts.
The depletion of FNR cause the downregulation of photosynthetic machinery and the induction of photoprotective mechanisms.
Title: Depletion of leaf-type ferredoxin-NADP(+) oxidoreductase results in the permanent induction of photoprotective mechanisms in Arabidopsis chloroplasts.
FNR1 mutants showed an enhanced rate of cyclic electron transfer under normal growth conditions.
Title: Comparative analysis of leaf-type ferredoxin-NADP oxidoreductase isoforms in Arabidopsis thaliana.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001085336.1

Supported by ESTs:

NM_126017.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables NADPH dehydrogenase activity	IDA Inferred from Direct Assay more info
enables electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	IDA Inferred from Direct Assay more info	PubMed
enables electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity	IDA Inferred from Direct Assay more info	PubMed
enables ferredoxin-NADP+ reductase activity	IEA Inferred from Electronic Annotation more info
enables poly(U) RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within photosynthetic electron transport chain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of tetrapyrrole biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apoplast	HDA more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	HDA more info	PubMed
located_in chloroplast stroma	HDA more info	PubMed
located_in chloroplast stroma	IDA Inferred from Direct Assay more info
located_in chloroplast thylakoid	HDA more info	PubMed
located_in chloroplast thylakoid membrane	HDA more info	PubMed
located_in chloroplast thylakoid membrane	IDA Inferred from Direct Assay more info
part_of chloroplast thylakoid membrane protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in plastid	HDA more info	PubMed
located_in thylakoid	HDA more info	PubMed
located_in thylakoid lumen	HDA more info	PubMed

General protein information

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Preferred Names: ferredoxin-NADP[+]-oxidoreductase 1

NP_001078805.1

LEAF FNR 1 (ATLFNR1); FUNCTIONS IN: oxidoreductase activity, electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity, poly(U) RNA binding, NADPH dehydrogenase activity, electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity; INVOLVED IN: oxidation reduction, photosynthetic electron transport chain, defense response to bacterium; LOCATED IN: thylakoid, chloroplast thylakoid membrane, apoplast, chloroplast stroma, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Ferredoxin reductase-type FAD-binding domain (InterPro:IPR017927), Oxidoreductase, FAD-binding domain (InterPro:IPR008333), Ferredoxin--NADP reductase (InterPro:IPR012146), Oxidoreductase FAD/NAD(P)-binding (InterPro:IPR001433), Riboflavin synthase-like beta-barrel (InterPro:IPR017938), Ferredoxin Reductase (InterPro:IPR015701), Flavoprotein pyridine nucleotide cytochrome reductase (InterPro:IPR001709); BEST Arabidopsis thaliana protein match is: ferredoxin-NADP(+)-oxidoreductase 2 (TAIR:AT1G20020.3); Has 7407 Blast hits to 7407 proteins in 1806 species: Archae - 24; Bacteria - 3962; Metazoa - 817; Fungi - 811; Plants - 610; Viruses - 0; Other Eukaryotes - 1183 (source: NCBI BLink).

NP_201420.1

ferredoxin-NADP(+)-oxidoreductase 1 (FNR1); FUNCTIONS IN: oxidoreductase activity, electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity, poly(U) RNA binding, NADPH dehydrogenase activity, electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity; INVOLVED IN: oxidation reduction, photosynthetic electron transport chain, defense response to bacterium; LOCATED IN: in 7 components; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Oxidoreductase FAD/NAD(P)-binding (InterPro:IPR001433), Ferredoxin reductase-type FAD-binding domain (InterPro:IPR017927), Oxidoreductase, FAD-binding domain (InterPro:IPR008333), Riboflavin synthase-like beta-barrel (InterPro:IPR017938), Ferredoxin Reductase (InterPro:IPR015701), Flavoprotein pyridine nucleotide cytochrome reductase (InterPro:IPR001709), Ferredoxin--NADP reductase (InterPro:IPR012146); BEST Arabidopsis thaliana protein match is: ferredoxin-NADP(+)-oxidoreductase 2 (TAIR:AT1G20020.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

26450964..26453199 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001085336.1 → NP_001078805.1 ferredoxin-NADP[+]-oxidoreductase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078805.1

Status: REVIEWED

UniProtKB/TrEMBL

B9DI26, F4JZ46

Conserved Domains (1) summary

cd06208
Location:15 → 262

CYPOR_like_FNR; These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer ...
NM_126017.5 → NP_201420.1 ferredoxin-NADP[+]-oxidoreductase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_201420.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WWE2, Q9FKW6, Q9SUJ3

UniProtKB/TrEMBL

A0A178UAK1, A0A5S9YHQ5, A0A654GFN6

Conserved Domains (1) summary

PLN03115
Location:1 → 360

PLN03115; ferredoxin--NADP(+) reductase; Provisional