IRX3 Cellulose synthase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: IRX3
Official Full Name: Cellulose synthase family protein
Primary source: TAIR:AT5G17420
Locus tag: AT5G17420
See related: Araport:AT5G17420
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCESA7; CELLULOSE SYNTHASE CATALYTIC SUBUNIT 7; CELLULOSE SYNTHASE CATALYTIC SUBUNIT; CELLULOSE SYNTHASE CATALYTIC SUBUNIT 7; CESA7; IRREGULAR XYLEM 3; MUR10; MURUS 10; T10B6.80; T10B6_80
Summary: Encodes a xylem-specific cellulose synthase that is phosphorylated on one or more serine residues (on either S185 or one of S180 or S181).
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Genomic context

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See IRX3 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 12

Sequence:: Chromosome: 5; NC_003076.8 (5736630..5741500, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CESA7 role in the cellulose microfibril biosynthesis in the secondary cell wall.
Title: Exploiting CELLULOSE SYNTHASE (CESA) Class Specificity to Probe Cellulose Microfibril Biosynthesis.
AtCesA6-null mutants showed a reduced cell elongation of young seedlings with little impact on cell division, which consequently affected cell wall integrity and biomass yield of mature plants. In comparison, rsw1 seedlings exhibited a strong defect in both cell elongation and division at restrictive temperature, whereas the IRX3 mutant showed normal seedling growth.
Title: Cellulose Synthase Mutants Distinctively Affect Cell Growth and Cell Wall Integrity for Plant Biomass Production in Arabidopsis.
Analysis of Arabidopsis CESA7 reveals four cysteines in variable region 2 (VR2) and two cysteines at the carboxy terminus (CT) as S-acylation sites.
Title: S-Acylation of the cellulose synthase complex is essential for its plasma membrane localization.
involved in the control of transpiration efficiency
Title: Cell wall composition contributes to the control of transpiration efficiency in Arabidopsis thaliana.
CesA7 has a role in cellulose biosynthesis, primary, and secondary cell wall structure.
Title: Interactions between MUR10/CesA7-dependent secondary cellulose biosynthesis and primary cell wall structure.
AtCesA7 is phosphorylated in vivo at two serine residues.
Title: Identification of cellulose synthase AtCesA7 (IRX3) in vivo phosphorylation sites--a potential role in regulating protein degradation.
Microarrays have been used to identify genes that exhibit a similar expression pattern to the secondary cell wall-specific cellulose synthase genes IRX1 and IRX3.
Title: Identification of novel genes in Arabidopsis involved in secondary cell wall formation using expression profiling and reverse genetics.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_121748.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables cellulose synthase (UDP-forming) activity	IEA Inferred from Electronic Annotation more info
enables cellulose synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cellulose synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
NOT involved_in cell wall thickening	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellulose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant-type cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant-type secondary cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhamnogalacturonan I side chain metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cellulose synthase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: Cellulose synthase family protein

NP_197244.1

IRREGULAR XYLEM 3 (IRX3); FUNCTIONS IN: cellulose synthase activity; INVOLVED IN: cellulose biosynthetic process, plant-type cell wall biogenesis, secondary cell wall biogenesis, rhamnogalacturonan I side chain metabolic process; LOCATED IN: plasma membrane, chloroplast; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Cellulose synthase (InterPro:IPR005150), Zinc finger, RING-type (InterPro:IPR001841); BEST Arabidopsis thaliana protein match is: Cellulose synthase family protein (TAIR:AT5G05170.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).