ACD6 ankyrin repeat family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ACD6
Official Full Name: ankyrin repeat family protein
Primary source: TAIR:AT4G14400
Locus tag: AT4G14400
See related: Araport:AT4G14400
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ACCELERATED CELL DEATH 6; DL3240W; FCAALL.190
Summary: encodes a novel protein with putative ankyrin and transmembrane regions. It is a member of one of the largest uncharacterized gene families in higher plants. The gene is involved in resistance to Pseudomonas syringae.
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Genomic context

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See ACD6 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 5

Sequence:: Chromosome: 4; NC_003075.7 (8294165..8299195)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ACCELERATED CELL DEATH 6 is a crucial genetic factor shaping the natural diversity of age- and salicylic acid-induced leaf senescence in Arabidopsis.
Title: ACCELERATED CELL DEATH 6 is a crucial genetic factor shaping the natural diversity of age- and salicylic acid-induced leaf senescence in Arabidopsis.
Small proteins modulate ion-channel-like ACD6 to regulate immunity in Arabidopsis thaliana.
Title: Small proteins modulate ion-channel-like ACD6 to regulate immunity in Arabidopsis thaliana.
Study propose that allelic diversity at SNC1 contributes to the maintenance of the hyperactive ACD6 variant in natural A. thaliana populations.
Title: Modulation of ACD6 dependent hyperimmunity by natural alleles of an Arabidopsis thaliana NLR resistance gene.
NLR gene can mask the activity of an ACD6 autoimmune allele in natural A. thaliana populations, thereby linking different arms of the plant immune system.
Title: Modulation of ACD6 dependent hyperimmunity by natural alleles of an Arabidopsis thaliana NLR resistance gene.
Data indicate protein kinases FLS2 and BAK1 contribute to autoimmune signaling in ACCELERATED CELL DEATH6 (ACD6) L591F amino acid substitution.
Title: Salicylic acid regulates Arabidopsis microbial pattern receptor kinase levels and signaling.
Salicylic acid signaling controls the maturation and localization of the arabidopsis defense protein ACCELERATED CELL DEATH6
Title: Salicylic acid signaling controls the maturation and localization of the arabidopsis defense protein ACCELERATED CELL DEATH6.
Here we show instead that hybrid necrosis can be triggered by interactions between variants of a single gene, ACD6 (ACCELERATED CELL DEATH 6).
Title: Activation of the Arabidopsis thaliana immune system by combinations of common ACD6 alleles.
The effects of mutation on the structure and function of ACD6 in response to salicylic acid and disease resistance are reported.
Title: Structure-function analysis of the plasma membrane- localized Arabidopsis defense component ACD6.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_117519.4

Supported by ESTs:

NM_179050.2

Supported by ESTs:

NM_179051.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cellular response to salicylic acid stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to oomycetes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of salicylic acid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to freezing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salicylic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to salicylic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to virus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ankyrin repeat family protein

NP_567430.1

ACCELERATED CELL DEATH 6 (ACD6); CONTAINS InterPro DOMAIN/s: Ankyrin repeat-containing domain (InterPro:IPR020683), Ankyrin repeat (InterPro:IPR002110); BEST Arabidopsis thaliana protein match is: Ankyrin repeat family protein (TAIR:AT4G14390.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_849381.1

ACCELERATED CELL DEATH 6 (ACD6); CONTAINS InterPro DOMAIN/s: Ankyrin repeat-containing domain (InterPro:IPR020683), Ankyrin repeat (InterPro:IPR002110); BEST Arabidopsis thaliana protein match is: Ankyrin repeat family protein (TAIR:AT4G14390.1); Has 17569 Blast hits to 9235 proteins in 440 species: Archae - 34; Bacteria - 1047; Metazoa - 9541; Fungi - 1051; Plants - 2075; Viruses - 52; Other Eukaryotes - 3769 (source: NCBI BLink).

NP_849382.1

ACCELERATED CELL DEATH 6 (ACD6); CONTAINS InterPro DOMAIN/s: Ankyrin repeat-containing domain (InterPro:IPR020683), Ankyrin repeat (InterPro:IPR002110); BEST Arabidopsis thaliana protein match is: Ankyrin repeat family protein (TAIR:AT4G14390.1); Has 17644 Blast hits to 9282 proteins in 441 species: Archae - 34; Bacteria - 1047; Metazoa - 9551; Fungi - 1051; Plants - 2112; Viruses - 52; Other Eukaryotes - 3797 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

8294165..8299195

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_117519.4 → NP_567430.1 ankyrin repeat family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567430.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B9DFF6, D9IWZ2, O23296, Q56YD7, Q682F8, Q8GW50, Q8LPS2

UniProtKB/TrEMBL

A0A346XQ96

Conserved Domains (4) summary

cd00204
Location:97 → 239

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:105 → 208

Ank_2; Ankyrin repeats (3 copies)

pfam13962
Location:506 → 594

PGG; Domain of unknown function

sd00045
Location:101 → 132

ANK; ANK repeat [structural motif]
NM_179050.2 → NP_849381.1 ankyrin repeat family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849381.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A346XQ96

Conserved Domains (4) summary

cd00204
Location:31 → 173

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:39 → 142

Ank_2; Ankyrin repeats (3 copies)

pfam13962
Location:440 → 528

PGG; Domain of unknown function

sd00045
Location:35 → 66

ANK; ANK repeat [structural motif]
NM_179051.1 → NP_849382.1 ankyrin repeat family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849382.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A346XQ96

Conserved Domains (4) summary

cd00204
Location:31 → 173

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:39 → 142

Ank_2; Ankyrin repeats (3 copies)

pfam13962
Location:440 → 528

PGG; Domain of unknown function

sd00045
Location:35 → 66

ANK; ANK repeat [structural motif]