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    UCH2 Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842876, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UCH2
    Official Full Name
    Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1
    Primary source
    TAIR:AT1G65650
    Locus tag
    AT1G65650
    See related
    Araport:AT1G65650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F1E22.3; UBIQUITIN C-TERMINAL HYDROLASE 2
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    Genomic context

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    See UCH2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (24415015..24417769, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene DegP protease 4 Neighboring gene miscRNA Neighboring gene Pre-mRNA splicing Prp18-interacting factor Neighboring gene cytochrome P450, family 702, subfamily A, polypeptide 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence that the Arabidopsis Ubiquitin C-terminal Hydrolases 1 and 2 associate with the 26S proteasome and the TREX-2 complex. Tian G, et al. Plant Signal Behav, 2012 Nov. PMID 22951400, Free PMC Article
    2. Ubiquitin C-terminal hydrolases 1 and 2 affect shoot architecture in Arabidopsis. Yang P, et al. Plant J, 2007 Aug. PMID 17559514
    3. COMPASS functions as a module of the INO80 chromatin remodeling complex to mediate histone H3K4 methylation in Arabidopsis. Shang JY, et al. Plant Cell, 2021 Oct 11. PMID 34270751, Free PMC Article
    4. AtEAF1 is a potential platform protein for Arabidopsis NuA4 acetyltransferase complex. Bieluszewski T, et al. BMC Plant Biol, 2015 Mar 5. PMID 25849764, Free PMC Article
    5. Identification of proteins that interact with catalytically active calcium-dependent protein kinases from Arabidopsis. Uno Y, et al. Mol Genet Genomics, 2009 Apr. PMID 19130088

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that UCH1 and UCH2 interact with the 26S proteasome lid subunits.
      Title: Evidence that the Arabidopsis Ubiquitin C-terminal Hydrolases 1 and 2 associate with the 26S proteasome and the TREX-2 complex.
    2. substantial effect on Arabidopsis shoot development, especially with respect to inflorescence architecture
      Title: Ubiquitin C-terminal hydrolases 1 and 2 affect shoot architecture in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    NM_105238.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within leaf development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within shoot system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within shoot system morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Ino80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1
    NP_564858.1
    • UCH2; CONTAINS InterPro DOMAIN/s: Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1 (InterPro:IPR001578), Ubiquitinyl hydrolase, UCH37 type (InterPro:IPR017390); BEST Arabidopsis thaliana protein match is: Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1 (TAIR:AT5G16310.1); Has 1283 Blast hits to 1275 proteins in 236 species: Archae - 0; Bacteria - 0; Metazoa - 633; Fungi - 351; Plants - 143; Viruses - 0; Other Eukaryotes - 156 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24415015..24417769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105238.3 → NP_564858.1  Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564858.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04482, Q945M7, Q9SHY9
      UniProtKB/TrEMBL
      A0A178WM46, A0A5S9WS88
      Conserved Domains (2) summary
      cd09617
      Location:3 → 220
      Peptidase_C12_UCH37_BAP1; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5) and BAP1
      pfam18031
      Location:269 → 314
      UCH_C; Ubiquitin carboxyl-terminal hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04482.1

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