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    TIM triosephosphate isomerase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816652, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TIM
    Official Full Name
    triosephosphate isomerase
    Primary source
    TAIR:AT2G21170
    Locus tag
    AT2G21170
    See related
    Araport:AT2G21170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F26H11.7; F26H11_7; PDTPI; PLASTID ISOFORM TRIOSE PHOSPHATE ISOMERASE; triosephosphate isomerase; TRIOSEPHOSPHATE ISOMERASE
    Summary
    Encodes a plastidic triose phosphate isomerase. Mutants with reduced pdTPI levels have difficulty transitioning from heterotrophic to autotrophic growth. The related phenotypes, such as chlorosis in light-grown seedlings may result from an accumulation of dihydroxyacetone phosphate (DHAP) and methylglyoxal (MG) in these mutants. Both splice variants appear to be expressed, but the At2g21170.2 variant appears to have a much narrower expression range limited to roots.
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    Genomic context

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    See TIM in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Sequence:
    Chromosome: 2; NC_003071.7 (9070734..9074470, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene XAP5 family protein Neighboring gene Translocon-associated protein (TRAP), alpha subunit Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The plastid isoform of triose phosphate isomerase is required for the postgerminative transition from heterotrophic to autotrophic growth in Arabidopsis. Chen M, et al. Plant Cell, 2010 Jan. PMID 20097871, Free PMC Article
    2. High light response of the thylakoid proteome in arabidopsis wild type and the ascorbate-deficient mutant vtc2-2. A comparative proteomics study. Giacomelli L, et al. Plant Physiol, 2006 Jun. PMID 16648217, Free PMC Article
    3. Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Bindschedler LV, et al. Phytochemistry, 2008 Jul. PMID 18538804
    4. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701
    5. Isolation and identification of ubiquitin-related proteins from Arabidopsis seedlings. Igawa T, et al. J Exp Bot, 2009. PMID 19429840, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084462.1
    NM_001335732.1
    NM_127687.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables triose-phosphate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables triose-phosphate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glyceraldehyde-3-phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within glycerol catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organismal reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within primary root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reductive pentose-phosphate cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within triglyceride mobilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in thylakoid HDA PubMed 

    General protein information

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    Preferred Names
    triosephosphate isomerase
    NP_001077931.1
    • triosephosphate isomerase (TIM); FUNCTIONS IN: triose-phosphate isomerase activity; INVOLVED IN: in 7 processes; LOCATED IN: thylakoid, mitochondrion, apoplast, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Triosephosphate isomerase, active site (InterPro:IPR020861), Aldolase-type TIM barrel (InterPro:IPR013785), Triosephosphate isomerase (InterPro:IPR000652); BEST Arabidopsis thaliana protein match is: triosephosphate isomerase (TAIR:AT3G55440.1); Has 11527 Blast hits to 11525 proteins in 3623 species: Archae - 144; Bacteria - 6185; Metazoa - 1204; Fungi - 240; Plants - 472; Viruses - 0; Other Eukaryotes - 3282 (source: NCBI BLink).
    NP_179713.1
    • triosephosphate isomerase (TIM); FUNCTIONS IN: triose-phosphate isomerase activity; INVOLVED IN: in 7 processes; LOCATED IN: in 6 components; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Triosephosphate isomerase, active site (InterPro:IPR020861), Aldolase-type TIM barrel (InterPro:IPR013785), Triosephosphate isomerase (InterPro:IPR000652); BEST Arabidopsis thaliana protein match is: triosephosphate isomerase (TAIR:AT3G55440.1); Has 11587 Blast hits to 11585 proteins in 3635 species: Archae - 138; Bacteria - 6210; Metazoa - 1207; Fungi - 243; Plants - 472; Viruses - 0; Other Eukaryotes - 3317 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      9070734..9074470 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127687.4 → NP_179713.1  triosephosphate isomerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179713.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SKP6
      UniProtKB/TrEMBL
      A0A178VN28, A0A5S9WZU4
      Conserved Domains (1) summary
      PLN02429
      Location:1 → 315
      PLN02429; triosephosphate isomerase

    2. NM_001335732.1 → NP_001323967.1  triosephosphate isomerase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SKP6
      UniProtKB/TrEMBL
      A0A178VN28, A0A5S9WZU4
      Conserved Domains (1) summary
      PLN02429
      Location:1 → 315
      PLN02429; triosephosphate isomerase

    3. NM_001084462.1 → NP_001077931.1  triosephosphate isomerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077931.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8MRE8
      Conserved Domains (1) summary
      PLN02429
      Location:1 → 306
      PLN02429; triosephosphate isomerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SKP6.1

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