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    UBA1A RNA-binding (RRM/RBD/RNP motifs) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816744, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UBA1A
    Official Full Name
    RNA-binding (RRM/RBD/RNP motifs) family protein
    Primary source
    TAIR:AT2G22090
    Locus tag
    AT2G22090
    See related
    Araport:AT2G22090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T16B14.6; T16B14_6
    Summary
    encodes a nuclear protein that binds to RNA with a specificity for oligouridylates in vitro. As with UBP1, transient overexpression of UBA1a in protoplasts increases the steady-state levels of reporter mRNAs in a promoter-dependent manner. Along with UBP1 and UBA2a, it may act as a component of a complex recognizing U-rich sequences in plant 3'-UTRs and contributing to the stabilization of mRNAs in the nucleus.
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    Genomic context

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    See UBA1A in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    2
    Sequence:
    Chromosome: 2; NC_003071.7 (9388260..9390575, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pentatricopeptide (PPR) repeat-containing protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene tRNA-Val

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UBA1 and UBA2, two proteins that interact with UBP1, a multifunctional effector of pre-mRNA maturation in plants. Lambermon MH, et al. Mol Cell Biol, 2002 Jun. PMID 12024044, Free PMC Article
    2. In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings. Reichel M, et al. Plant Cell, 2016 Oct. PMID 27729395, Free PMC Article
    3. Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method. Bach-Pages M, et al. Biomolecules, 2020 Apr 24. PMID 32344669, Free PMC Article
    4. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_127778.5
    NM_179690.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mRNA 3'-UTR AU-rich region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA stabilization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding (RRM/RBD/RNP motifs) family protein
    NP_565525.1
    • UBA1A; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: RNA recognition motif (RRM)-containing protein (TAIR:AT2G19380.1); Has 13884 Blast hits to 11620 proteins in 712 species: Archae - 0; Bacteria - 872; Metazoa - 7516; Fungi - 1398; Plants - 2946; Viruses - 0; Other Eukaryotes - 1152 (source: NCBI BLink).
    NP_850021.1
    • UBA1A; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: RNA recognition motif (RRM)-containing protein (TAIR:AT2G19380.1); Has 13893 Blast hits to 11626 proteins in 713 species: Archae - 0; Bacteria - 872; Metazoa - 7522; Fungi - 1400; Plants - 2947; Viruses - 0; Other Eukaryotes - 1152 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      9388260..9390575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127778.5 → NP_565525.1  RNA-binding (RRM/RBD/RNP motifs) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565525.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q680T3, Q8L990, Q8RYD4, Q8VZW7, Q9SHZ6
      UniProtKB/TrEMBL
      A0A178VVY2
      Conserved Domains (2) summary
      COG0724
      Location:104 → 164
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12384
      Location:104 → 179
      RRM_RBM24_RBM38_like; RNA recognition motif in eukaryotic RNA-binding protein RBM24, RBM38 and similar proteins

    2. NM_179690.1 → NP_850021.1  RNA-binding (RRM/RBD/RNP motifs) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850021.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VVY2, A0A654EV19, F4IIL5
      Conserved Domains (1) summary
      cl17169
      Location:104 → 179
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SHZ6.2

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