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    TPS1 trehalose-6-phosphate synthase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844194, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TPS1
    Official Full Name
    trehalose-6-phosphate synthase
    Primary source
    TAIR:AT1G78580
    Locus tag
    AT1G78580
    See related
    Araport:AT1G78580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATTPS1; T30F21.9; T30F21_9; trehalose-6-phosphate synthase; TREHALOSE-6-PHOSPHATE SYNTHASE 1
    Summary
    Encodes an enzyme putatively involved in trehalose biosynthesis. The protein has a trehalose synthase (TPS)-like domain but no trehalose phosphatase (TPP)-like domain. ATTPS1 is able to complement yeast tps1 mutants in vivo. The gene product modulates cell growth but not cell differentiation by determining cell wall deposition and cell division.
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    Genomic context

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    See TPS1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    20
    Sequence:
    Chromosome: 1; NC_003070.9 (29552340..29560912, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Sodium Bile acid symporter family Neighboring gene ncRNA Neighboring gene rhamnose biosynthesis 1 Neighboring gene ncRNA Neighboring gene NAD(H) kinase 3 Neighboring gene light-regulated zinc finger protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural variation of warm temperature-induced raffinose accumulation identifies TREHALOSE-6-PHOSPHATE SYNTHASE 1 as a modulator of thermotolerance. Reichelt N, et al. Plant Cell Environ, 2023 Nov. PMID 37427798
    2. The trehalose 6-phosphate pathway impacts vegetative phase change in Arabidopsis thaliana. Ponnu J, et al. Plant J, 2020 Nov. PMID 32799402
    3. Functional Features of TREHALOSE-6-PHOSPHATE SYNTHASE1, an Essential Enzyme in Arabidopsis. Fichtner F, et al. Plant Cell, 2020 Jun. PMID 32276986, Free PMC Article
    4. Regulation of flowering by trehalose-6-phosphate signaling in Arabidopsis thaliana. Wahl V, et al. Science, 2013 Feb 8. PMID 23393265
    5. AtTPS1-mediated trehalose 6-phosphate synthesis is essential for embryogenic and vegetative growth and responsiveness to ABA in germinating seeds and stomatal guard cells. Gómez LD, et al. Plant J, 2010 Oct. PMID 20659274

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Natural variation of warm temperature-induced raffinose accumulation identifies TREHALOSE-6-PHOSPHATE SYNTHASE 1 as a modulator of thermotolerance.
      Title: Natural variation of warm temperature-induced raffinose accumulation identifies TREHALOSE-6-PHOSPHATE SYNTHASE 1 as a modulator of thermotolerance.
    2. The trehalose 6-phosphate pathway impacts vegetative phase change in Arabidopsis thaliana.
      Title: The trehalose 6-phosphate pathway impacts vegetative phase change in Arabidopsis thaliana.
    3. TPS1 is required for sucrose-induced hypocotyl elongation in light/dark cycles.
      Title: The Energy-Signaling Hub SnRK1 Is Important for Sucrose-Induced Hypocotyl Elongation.
    4. Data suggest that Arabidopsis thaliana exhibits three active trehalose-6-phosphate synthase isoforms: TPS1, TPS2, and TPS4.
      Title: Trehalose-6-phosphate synthase 1 is not the only active TPS in Arabidopsis thaliana.
    5. loss of TPS1 causes extremely late flowering; this suggests TPS1 is required for timely initiation of flowering; findings show the trehalose-6-phosphate pathway affects flowering both in leaves and at the shoot meristem, and integrate TPS1 into the existing genetic framework of flowering-time control
      Title: Regulation of flowering by trehalose-6-phosphate signaling in Arabidopsis thaliana.
    6. TSP1 plays an essential role in regulating the growth of vegetative as well as embryogenic tissue in a mechanism involving ABA and sugar metabolism.
      Title: AtTPS1-mediated trehalose 6-phosphate synthesis is essential for embryogenic and vegetative growth and responsiveness to ABA in germinating seeds and stomatal guard cells.
    7. TPS1 may play a major role in coordinating cell wall biosynthesis and cell division with cellular metabolism during embryo development.
      Title: Delayed embryo development in the ARABIDOPSIS TREHALOSE-6-PHOSPHATE SYNTHASE 1 mutant is associated with altered cell wall structure, decreased cell division and starch accumulation.
    8. It can be expected that TPS1 from tobacco has a relatively high similarity to the TPS of Arabidopsis thaliana.
      Title: Immunogold localization of trehalose-6-phosphate synthase in leaf segments of wild-type and transgenic tobacco plants expressing the AtTPS1 gene from Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001334832.1
    NM_001334833.1
    NM_001334834.1
    NM_106505.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within developmental vegetative growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within long-day photoperiodism, flowering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sugar mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trehalose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within trehalose metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trehalose-6-phosphate synthase
    NP_001319403.1
    • trehalose-6-phosphate synthase (TPS1); CONTAINS InterPro DOMAIN/s: Alpha,alpha-trehalose-phosphate synthase (InterPro:IPR012766), Glycosyl transferase, family 20 (InterPro:IPR001830), Trehalose-phosphatase (InterPro:IPR003337); BEST Arabidopsis thaliana protein match is: trehalose-phosphatase/synthase 2 (TAIR:AT1G16980.1); Has 6189 Blast hits to 3807 proteins in 1021 species: Archae - 45; Bacteria - 1772; Metazoa - 831; Fungi - 808; Plants - 384; Viruses - 0; Other Eukaryotes - 2349 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      29552340..29560912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001334832.1 → NP_001319403.1  trehalose-6-phosphate synthase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P93653, Q94K55, Q9SYM4
      UniProtKB/TrEMBL
      A0A178WG51, A0A384L3B9, A0A5S9WVI6, W8PVS8
      Conserved Domains (1) summary
      PLN03064
      Location:1 → 941
      PLN03064; alpha,alpha-trehalose-phosphate synthase (UDP-forming); Provisional

    2. NM_106505.5 → NP_177979.1  trehalose-6-phosphate synthase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177979.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P93653, Q94K55, Q9SYM4
      UniProtKB/TrEMBL
      A0A178WG51, A0A384L3B9, A0A5S9WVI6, W8PVS8
      Conserved Domains (1) summary
      PLN03064
      Location:1 → 941
      PLN03064; alpha,alpha-trehalose-phosphate synthase (UDP-forming); Provisional

    3. NM_001334833.1 → NP_001322931.1  trehalose-6-phosphate synthase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P93653, Q94K55, Q9SYM4
      UniProtKB/TrEMBL
      A0A178WG51, A0A384L3B9, A0A5S9WVI6, W8PVS8
      Conserved Domains (1) summary
      PLN03064
      Location:1 → 941
      PLN03064; alpha,alpha-trehalose-phosphate synthase (UDP-forming); Provisional

    4. NM_001334834.1 → NP_001322932.1  trehalose-6-phosphate synthase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P93653, Q94K55, Q9SYM4
      UniProtKB/TrEMBL
      A0A178WG51, A0A384L3B9, A0A5S9WVI6, W8PVS8
      Conserved Domains (1) summary
      PLN03064
      Location:1 → 941
      PLN03064; alpha,alpha-trehalose-phosphate synthase (UDP-forming); Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SYM4.1

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