Endosomal targeting BRO1-like domain-containing protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Full Name: Endosomal targeting BRO1-like domain-containing protein
Primary source: TAIR:AT1G15130
Locus tag: AT1G15130
See related: Araport:AT1G15130
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F9L1.7; F9L1_7
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Genomic context

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See in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 8

Sequence:: Chromosome: 1; NC_003070.9 (5206002..5209979, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plant ESCRT protein ALIX coordinates with retromer complex in regulating receptor-mediated sorting of soluble vacuolar proteins.
Title: Plant ESCRT protein ALIX coordinates with retromer complex in regulating receptor-mediated sorting of soluble vacuolar proteins.
Biochemical and Imaging Analysis of ALIX Function in Endosomal Trafficking of Arabidopsis Protein Cargoes.
Title: Biochemical and Imaging Analysis of ALIX Function in Endosomal Trafficking of Arabidopsis Protein Cargoes.
Arabidopsis (Arabidopsis thaliana) ALIX directly binds to ABA receptors in late endosomes, promoting their degradation. [ALIX]
Title: Arabidopsis ALIX Regulates Stomatal Aperture and Turnover of Abscisic Acid Receptors.
ALIX (AT1G15130) is a major player in membrane protein processing through the plant endomembrane system and in vacuolar biogenesis.ALIX mediates high-affinity phosphate transporter trafficking to maintain phosphate homeostasis.
Title: ESCRT-III-Associated Protein ALIX Mediates High-Affinity Phosphate Transporter Trafficking to Maintain Phosphate Homeostasis in Arabidopsis.
Data indicate that ALIX (At1g15130) protein could function as an important regulator for AMSH-like ubiquitin thiolesterase 3 (AMSH3) function at the late endosomes.
Title: Arabidopsis ALIX is required for the endosomal localization of the deubiquitinating enzyme AMSH3.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_101381.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within endosome to plasma membrane protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multivesicular body organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuole organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: Endosomal targeting BRO1-like domain-containing protein

NP_172965.1

Endosomal targeting BRO1-like domain-containing protein; CONTAINS InterPro DOMAIN/s: BRO1 (InterPro:IPR004328); Has 26948 Blast hits to 15985 proteins in 1003 species: Archae - 32; Bacteria - 2662; Metazoa - 9770; Fungi - 4642; Plants - 6039; Viruses - 612; Other Eukaryotes - 3191 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

5206002..5209979 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_101381.3 → NP_172965.1 Endosomal targeting BRO1-like domain-containing protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_172965.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4HXZ1, Q8H1H8, Q9XI56

UniProtKB/TrEMBL

A0A178W2A6, A0A5S9UHN9

Conserved Domains (2) summary

cd09238
Location:371 → 707

V_Alix_like_1; Protein-interacting V-domain of an uncharacterized family of the V_Alix_like superfamily

cd09246
Location:10 → 365

BRO1_Alix_like_1; Protein-interacting, N-terminal, Bro1-like domain of an Uncharacterized family of the BRO1_Alix_like superfamily