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    PEX13 peroxin 13 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819945, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PEX13
    Official Full Name
    peroxin 13
    Primary source
    TAIR:AT3G07560
    Locus tag
    AT3G07560
    See related
    Araport:AT3G07560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ABERRANT PEROXISOME MORPHOLOGY 2; APM2; peroxin 13
    Summary
    Encodes peroxin 13 (PEX13) involved in protein transport into peroxisomes, for example, peroxisomal import of nitric oxide synthase.
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    Genomic context

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    See PEX13 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (2411321..2413587, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene autophagocytosis-associated family protein Neighboring gene integrator complex subunit Neighboring gene Actin-binding FH2 (formin homology 2) family protein Neighboring gene RNI-like superfamily protein Neighboring gene histone H2A deubiquitinase (DUF3755) Neighboring gene fanconi anemia group D2 protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A viable Arabidopsis pex13 missense allele confers severe peroxisomal defects and decreases PEX5 association with peroxisomes. Woodward AW, et al. Plant Mol Biol, 2014 Sep. PMID 25008153, Free PMC Article
    2. Reducing PEX13 expression ameliorates physiological defects of late-acting peroxin mutants. Ratzel SE, et al. Traffic, 2011 Jan. PMID 20969679, Free PMC Article
    3. The peroxin loss-of-function mutation abstinence by mutual consent disrupts male-female gametophyte recognition. Boisson-Dernier A, et al. Curr Biol, 2008 Jan 8. PMID 18160292, Free PMC Article
    4. Peroxisomes are required for in vivo nitric oxide accumulation in the cytosol following salinity stress of Arabidopsis plants. Corpas FJ, et al. Plant Physiol, 2009 Dec. PMID 19783645, Free PMC Article
    5. Arabidopsis DAYU/ABERRANT PEROXISOME MORPHOLOGY9 is a key regulator of peroxisome biogenesis and plays critical roles during pollen maturation and germination in planta. Li XR, et al. Plant Cell, 2014 Feb. PMID 24510720, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PEX13 has a role in plant peroxisome receptor docking and matrix protein import.
      Title: A viable Arabidopsis pex13 missense allele confers severe peroxisomal defects and decreases PEX5 association with peroxisomes.
    2. pex13-1 allele had deleterious effects when combined with pex5-1 and pex14-2, which are defective in early-acting peroxins, as shown by reduced matrix protein import and enhanced physiological defects
      Title: Reducing PEX13 expression ameliorates physiological defects of late-acting peroxin mutants.
    3. AMC is strongly and transiently expressed in both male and female gametophytes during fertilization and functions in gametophytes as a peroxin essential for protein import into peroxisomes.
      Title: The peroxin loss-of-function mutation abstinence by mutual consent disrupts male-female gametophyte recognition.
    4. APM2/PEX13 and APM4/PEX12 have roles in both PTS1- and PTS2-dependent protein transport on the peroxisomal membrane. [APM2] [PEX13]
      Title: The Arabidopsis pex12 and pex13 mutants are defective in both PTS1- and PTS2-dependent protein transport to peroxisomes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_111634.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein import into peroxisome matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein import into peroxisome matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix, docking IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxin 13
    NP_187412.1
    • peroxin 13 (PEX13); Has 58927 Blast hits to 16541 proteins in 1193 species: Archae - 47; Bacteria - 25769; Metazoa - 16443; Fungi - 3404; Plants - 6224; Viruses - 432; Other Eukaryotes - 6608 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      2411321..2413587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111634.6 → NP_187412.1  peroxin 13 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187412.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z2M3, Q9SRR0
      UniProtKB/TrEMBL
      A0A178VBD0, A0A5S9XA12, A0A7G2EKS1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SRR0.1

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