MYC4 Basic helix-loop-helix (bHLH) DNA-binding family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MYC4
Official Full Name: Basic helix-loop-helix (bHLH) DNA-binding family protein
Primary source: TAIR:AT4G17880
Locus tag: AT4G17880
See related: Araport:AT4G17880
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: T6K21.60; T6K21_60
Summary: MYC4 is a JAZ-interacting transcription factor that act together with MYC2 and MYC3 to activate JA-responses.
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Genomic context

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See MYC4 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 1

Sequence:: Chromosome: 4; NC_003075.7 (9933326..9935685, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MYC2, MYC3, and MYC4 function additively in wounding-induced jasmonic acid biosynthesis and catabolism.
Title: MYC2, MYC3, and MYC4 function additively in wounding-induced jasmonic acid biosynthesis and catabolism.
MYC4 positively regulates secondary cell wall thickening under blue light.MYC4 binds to the NST1 promoter directly.
Title: Blue Light Regulates Secondary Cell Wall Thickening via MYC2/MYC4 Activation of the NST1-Directed Transcriptional Network in Arabidopsis.
The function of MYC2, MYC3, and MYC4 in seed development and seed storage protein accumulation
Title: MYC2, MYC3, and MYC4 function redundantly in seed storage protein accumulation in Arabidopsis.
regulator of glucosinolate biosynthesis
Title: bHLH05 is an interaction partner of MYB51 and a novel regulator of glucosinolate biosynthesis in Arabidopsis.
MYC2/MYC3/MYC4 are necessary for direct transcriptional activation of GS biosynthesis genes.
Title: Arabidopsis basic helix-loop-helix transcription factors MYC2, MYC3, and MYC4 regulate glucosinolate biosynthesis, insect performance, and feeding behavior.
MYC3 and MYC4, act additively with MYC2 in the activation of jasmonic acid responses.
Title: The Arabidopsis bHLH transcription factors MYC3 and MYC4 are targets of JAZ repressors and act additively with MYC2 in the activation of jasmonate responses.
results suggest that MYC3 and MYC4 are JAZ-interacting transcription factors that regulate jasmonate responses
Title: Characterization of JAZ-interacting bHLH transcription factors that regulate jasmonate responses in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_117897.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables bHLH transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anthocyanin-containing compound biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extracellular ATP signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of secondary cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stomatal complex development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Basic helix-loop-helix (bHLH) DNA-binding family protein

NP_193522.1

Basic helix-loop-helix (bHLH) DNA-binding family protein; FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: Basic helix-loop-helix (bHLH) DNA-binding family protein (TAIR:AT5G46760.1); Has 4061 Blast hits to 3773 proteins in 423 species: Archae - 0; Bacteria - 20; Metazoa - 552; Fungi - 119; Plants - 3303; Viruses - 13; Other Eukaryotes - 54 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

9933326..9935685 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_117897.4 → NP_193522.1 Basic helix-loop-helix (bHLH) DNA-binding family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_193522.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O49687, Q8W2F6

UniProtKB/TrEMBL

A0A5S9XU56

Conserved Domains (2) summary

cd00083
Location:415 → 466

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam14215
Location:63 → 250

bHLH-MYC_N; bHLH-MYC and R2R3-MYB transcription factors N-terminal