IPK1 inositol-pentakisphosphate 2-kinase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: IPK1
Official Full Name: inositol-pentakisphosphate 2-kinase 1
Primary source: TAIR:AT5G42810
Locus tag: AT5G42810
See related: Araport:AT5G42810
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATIPK1; inositol-pentakisphosphate 2-kinase 1; M40H3; MJB21.19; MJB21_19
Summary: Encodes an inositol tetra-/pentaphosphate 2-kinase, involved in the biosynthesis of phytic acid, a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate and mineral storage compound in plant seeds. Is also required for growth and modulates phosphate homeostasis at the transcriptional level.
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Genomic context

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See IPK1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 7

Sequence:: Chromosome: 5; NC_003076.8 (17166702..17169459)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis inositol polyphosphate kinases IPK1 and ITPK1 modulate crosstalk between SA-dependent immunity and phosphate-starvation responses.
Title: Arabidopsis inositol polyphosphate kinases IPK1 and ITPK1 modulate crosstalk between SA-dependent immunity and phosphate-starvation responses.
An ATP-responsive metabolic cassette comprised of inositol tris/tetrakisphosphate kinase 1 (ITPK1) and inositol pentakisphosphate 2-kinase (IPK1) buffers diphosphosphoinositol phosphate levels.
Title: An ATP-responsive metabolic cassette comprised of inositol tris/tetrakisphosphate kinase 1 (ITPK1) and inositol pentakisphosphate 2-kinase (IPK1) buffers diphosphosphoinositol phosphate levels.
a particular mechanism of Arsenic(V) toxicity existed in atipk1-1 mutant.
Title: An Arabidopsis mutant of inositol pentakisphosphate 2-kinase AtIPK1 displays reduced arsenate tolerance.
Expression of the Gle1 variants with enhanced Myo-inositol-1,2,3,4,5,6-hexakisphosphate (InsP(6)) sensitivity rescues the mRNA export defect of the ipk1 (inositol 1,3,4,5,6-pentakisphosphate 2-kinase) InsP(6)-deficient mutant.
Title: InsP6-sensitive variants of the Gle1 mRNA export factor rescue growth and fertility defects of the ipk1 low-phytic-acid mutation in Arabidopsis.
IPK is indeed a member of the plant terpenoid metabolic network.
Title: Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants.
AtIPK1 has important roles in growth and phosphate (Pi) homeostasis.
Title: Arabidopsis inositol pentakisphosphate 2-kinase, AtIPK1, is required for growth and modulates phosphate homeostasis at the transcriptional level.
Conformational changes in inositol 1,3,4,5,6-pentakisphosphate 2-kinase upon substrate binding: role of N-terminal lobe and enantiomeric substrate preference.
Title: Conformational changes in inositol 1,3,4,5,6-pentakisphosphate 2-kinase upon substrate binding: role of N-terminal lobe and enantiomeric substrate preference.
Report that limited proteolysis has revealed the presence of multiple conformational states in the IPK1 catalytic cycle and propose a model for recognition of IP substrate by IPK1.
Title: Inositol phosphate-induced stabilization of inositol 1,3,4,5,6-pentakisphosphate 2-kinase and its role in substrate specificity.
The isolation and characterization of ATIPK1 is reported.
Title: Characterization of an Arabidopsis inositol 1,3,4,5,6-pentakisphosphate 2-kinase (AtIPK1).

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MASC_STS14193 (e-PCR)
- UniSTS:258692

NM_123646.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1,4,5,6-tetrakisphosphate 2-kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular phosphate ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral root development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myo-inositol hexakisphosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphate ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: inositol-pentakisphosphate 2-kinase 1

NP_568613.1

inositol-pentakisphosphate 2-kinase 1 (IPK1); CONTAINS InterPro DOMAIN/s: Inositol-pentakisphosphate 2-kinase, metazoa (InterPro:IPR018009), Inositol-pentakisphosphate 2-kinase (InterPro:IPR009286); BEST Arabidopsis thaliana protein match is: Inositol-pentakisphosphate 2-kinase family protein (TAIR:AT1G22100.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

17166702..17169459

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_123646.4 → NP_568613.1 inositol-pentakisphosphate 2-kinase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568613.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93YN9, Q9FMY6

UniProtKB/TrEMBL

A0A654G8F2

Conserved Domains (1) summary

pfam06090
Location:15 → 425

Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase