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    PRK6 Leucine-rich repeat protein kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832192, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PRK6
    Official Full Name
    Leucine-rich repeat protein kinase family protein
    Primary source
    TAIR:AT5G20690
    Locus tag
    AT5G20690
    See related
    Araport:AT5G20690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    pollen receptor like kinase 6; T1M15.90; T1M15_90
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    Genomic context

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    See PRK6 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (7002453..7004775)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene DUF1677 family protein (DUF1677) Neighboring gene TRICHOME BIREFRINGENCE-LIKE 16 Neighboring gene senescence-associated family protein, putative (DUF581) Neighboring gene beta-galactosidase 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis PRK6 interacts specifically with AtRopGEF8/12 and induces depolarized growth of pollen tubes when overexpressed. Yu Y, et al. Sci China Life Sci, 2018 Jan. PMID 28795376
    2. AtLURE1/PRK6-mediated signaling promotes conspecific micropylar pollen tube guidance. Liu M, et al. Plant Physiol, 2021 Jun 11. PMID 33638984, Free PMC Article
    3. The phospholipid flippase ALA3 regulates pollen tube growth and guidance in Arabidopsis. Yang Y, et al. Plant Cell, 2022 Sep 27. PMID 35861414, Free PMC Article
    4. Tip-localized receptors control pollen tube growth and LURE sensing in Arabidopsis. Takeuchi H, et al. Nature, 2016 Mar 10. PMID 26961657
    5. Structural basis for receptor recognition of pollen tube attraction peptides. Zhang X, et al. Nat Commun, 2017 Nov 6. PMID 29109411, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtLURE1/PRK6-mediated signaling promotes conspecific micropylar pollen tube guidance.
      Title: AtLURE1/PRK6-mediated signaling promotes conspecific micropylar pollen tube guidance.
    2. Arabidopsis pollen receptor like kinase 6 (AtPRK6) is localized to the plasma membrane and expressed specifically in pollen tubes. The interactions between AtPRK6 and Arabidopsis Rop guanine nucleotide exchange factors AtRopGEF8 and AtRopGEF12 are mediated by the C-termini of AtRopGEF8/12 and by the juxtamembrane and kinase domain of AtPRK6, but are not dependent on the kinase activity.
      Title: Arabidopsis PRK6 interacts specifically with AtRopGEF8/12 and induces depolarized growth of pollen tubes when overexpressed.
    3. Structural study reveals that a C-terminal loop of the LRR domain (AtPRK6(LRR)) is responsible for recognition of AtLURE1.2, mediated by a set of residues largely conserved among PRK6 homologs from Arabidopsis lyrata and Capsella rubella, supported by in vitro mutagenesis and semi-in-vivo pollen tube growth assays.
      Title: Structural basis for receptor recognition of pollen tube attraction peptides.
    4. PRK6 acts as a key membrane receptor for external AtLURE1 attractants, and recruits the core tip-growth machinery, including ROP signalling proteins. [PRK6]
      Title: Tip-localized receptors control pollen tube growth and LURE sensing in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within pollen tube guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pollen tube guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in pollen tube tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Leucine-rich repeat protein kinase family protein
    NP_197569.2
    • Leucine-rich repeat protein kinase family protein; FUNCTIONS IN: protein serine/threonine kinase activity, kinase activity, ATP binding; INVOLVED IN: transmembrane receptor protein tyrosine kinase signaling pathway, protein amino acid phosphorylation; LOCATED IN: endomembrane system; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, C globular stage, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat protein kinase family protein (TAIR:AT3G42880.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      7002453..7004775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122076.3 → NP_197569.2  Leucine-rich repeat protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197569.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3E991
      UniProtKB/TrEMBL
      A0A178UD78, A0A5S9Y5X8, A0A654G2Z3
      Conserved Domains (4) summary
      PLN00113
      Location:70 → 657
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:98 → 120
      LRR_RI; leucine-rich repeat [structural motif]
      pfam08263
      Location:34 → 67
      LRRNT_2; Leucine rich repeat N-terminal domain
      cl21453
      Location:390 → 656
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3E991.4

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