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    Wdr6 WD repeat domain 6 [ Mus musculus (house mouse) ]

    Gene ID: 83669, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wdr6provided by MGI
    Official Full Name
    WD repeat domain 6provided by MGI
    Primary source
    MGI:MGI:1930140
    See related
    Ensembl:ENSMUSG00000066357 AllianceGenome:MGI:1930140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable enzyme regulator activity; insulin receptor substrate binding activity; and tRNA binding activity. Predicted to be involved in negative regulation of autophagy; negative regulation of cell population proliferation; and wobble position ribose methylation. Predicted to act upstream of with a negative effect on G1 to G0 transition. Predicted to be located in cytosol and plasma membrane. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm. Is expressed in nervous system and neural retina. Orthologous to human WDR6 (WD repeat domain 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 110.8), CNS E14 (RPKM 87.9) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Wdr6 in Genome Data Viewer
    Location:
    9 F2; 9 59.51 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108449510..108455862, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108572311..108578713, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3863 Neighboring gene DALR anticodon binding domain containing 3 Neighboring gene microRNA 191 Neighboring gene microRNA 425 Neighboring gene STARR-seq mESC enhancer starr_25213 Neighboring gene STARR-seq mESC enhancer starr_25214 Neighboring gene prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) Neighboring gene ariadne RBR E3 ubiquitin protein ligase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:108551788-108551897 Neighboring gene STARR-seq mESC enhancer starr_25220

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables insulin receptor substrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in G1 to G0 transition IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_negative_effect G1 to G0 transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in wobble position ribose methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in wobble position ribose methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tRNA (34-2'-O)-methyltransferase regulator WDR6
    Names
    WD repeat-containing protein 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031392.4NP_113569.1  tRNA (34-2'-O)-methyltransferase regulator WDR6

      See identical proteins and their annotated locations for NP_113569.1

      Status: VALIDATED

      Source sequence(s)
      CT010508, CT571271
      Consensus CDS
      CCDS23532.2
      UniProtKB/Swiss-Prot
      Q99ME2
      UniProtKB/TrEMBL
      Q3TEZ2
      Related
      ENSMUSP00000070927.6, ENSMUST00000068700.7
      Conserved Domains (3) summary
      COG2319
      Location:79388
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:212252
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:110325
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108449510..108455862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)