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    Stmp1 short transmembrane mitochondrial protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 67705, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Stmp1provided by MGI
    Official Full Name
    short transmembrane mitochondrial protein 1provided by MGI
    Primary source
    MGI:MGI:1914955
    See related
    Ensembl:ENSMUSG00000073155 AllianceGenome:MGI:1914955
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mm47; 1810058I24Rik
    Summary
    Involved in mitochondrial respiratory chain complex III assembly; positive regulation of NLRP3 inflammasome complex assembly; and positive regulation of interleukin-1 beta production. Located in mitochondrial intermembrane space and mitochondrial outer membrane. Is active in mitochondrial inner membrane. Is expressed in retina. Orthologous to human STMP1 (short transmembrane mitochondrial protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 52.4), heart adult (RPKM 49.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stmp1 in Genome Data Viewer
    Location:
    6 B1; 6 15.26 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (35229645..35238574)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (35252710..35261639)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex, subunit 4 Neighboring gene STARR-positive B cell enhancer ABC_E2779 Neighboring gene predicted gene, 33046 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:35141265-35141448 Neighboring gene nucleoporin 205 Neighboring gene STARR-seq mESC enhancer starr_15553 Neighboring gene STARR-seq mESC enhancer starr_15554 Neighboring gene predicted gene, 23435 Neighboring gene STARR-seq mESC enhancer starr_15555 Neighboring gene solute carrier family 13 (sodium/sulfate symporters), member 4 Neighboring gene family with sequence similarity 180, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mitochondrial micropeptide Stmp1 promotes retinal cell differentiation. Zheng X, et al. Biochem Biophys Res Commun, 2022 Dec 25. PMID 36368158
    2. A Mitochondrial Micropeptide Is Required for Activation of the Nlrp3 Inflammasome. Bhatta A, et al. J Immunol, 2020 Jan 15. PMID 31836654, Free PMC Article
    3. A lncRNA-encoded mitochondrial micropeptide exacerbates microglia-mediated neuroinflammation in retinal ischemia/reperfusion injury. Zheng X, et al. Cell Death Dis, 2023 Feb 15. PMID 36792584, Free PMC Article
    4. The cardiac-enriched microprotein mitolamban regulates mitochondrial respiratory complex assembly and function in mice. Makarewich CA, et al. Proc Natl Acad Sci U S A, 2022 Feb 8. PMID 35101990, Free PMC Article
    5. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mitochondrial micropeptide Stmp1 promotes retinal cell differentiation.
      Title: The mitochondrial micropeptide Stmp1 promotes retinal cell differentiation.
    2. The cardiac-enriched microprotein mitolamban regulates mitochondrial respiratory complex assembly and function in mice.
      Title: The cardiac-enriched microprotein mitolamban regulates mitochondrial respiratory complex assembly and function in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respirasome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial respirasome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of NLRP3 inflammasome complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-1 beta production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    short transmembrane mitochondrial protein 1
    Names
    mitochondrial micropeptide-47
    protein mitolamban

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384235.2 → NP_001371164.1  short transmembrane mitochondrial protein 1

      Status: VALIDATED

      Source sequence(s)
      AC158681
      UniProtKB/Swiss-Prot
      A0A5F8MPG2, P0DP99, Q3TAI1
      Related
      ENSMUSP00000158958.2, ENSMUST00000152147.8
      Conserved Domains (1) summary
      pfam15054
      Location:4 → 44
      DUF4535; Domain of unknown function (DUF4535)

    RNA

    1. NR_169139.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158681

    2. NR_169140.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158681
      Related
      ENSMUST00000130875.8

    3. NR_169141.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158681

    4. NR_169142.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158681

    5. NR_169143.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC158681

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      35229645..35238574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_015608.1: Suppressed sequence

      Description
      NR_015608.1: This RefSeq was removed because it is now thought that this gene does encode a protein.

    2. NR_027875.1: Suppressed sequence

      Description
      NR_027875.1: This RefSeq was removed by NCBI staff.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DP99.2 GenPept UniProtKB/Swiss-Prot:P0DP99

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.