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    Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 73341, updated on 3-Dec-2024

    Summary

    Official Symbol
    Arhgef6provided by MGI
    Official Full Name
    Rac/Cdc42 guanine nucleotide exchange factor 6provided by MGI
    Primary source
    MGI:MGI:1920591
    See related
    Ensembl:ENSMUSG00000031133 AllianceGenome:MGI:1920591
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    alpha-PIX; 1600028C08Rik; 1700038J06Rik; 4930592P22Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in lamellipodium assembly. Located in cell-cell junction and lamellipodium. Is expressed in liver; somite; testis; and unsegmented mesenchyme. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in placenta adult (RPKM 38.2), thymus adult (RPKM 12.8) and 12 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Arhgef6 in Genome Data Viewer
    Location:
    X A6; X 31.26 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (56276845..56384119, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (57231485..57338758, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14718 Neighboring gene CD40 ligand Neighboring gene STARR-positive B cell enhancer ABC_E7690 Neighboring gene STARR-seq mESC enhancer starr_47212 Neighboring gene STARR-positive B cell enhancer ABC_E7691 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:54563182-54563369 Neighboring gene STARR-seq mESC enhancer starr_47213 Neighboring gene STARR-seq mESC enhancer starr_47214 Neighboring gene small nucleolar RNA, C/D box 61 Neighboring gene RNA binding motif protein, X chromosome Neighboring gene transmembrane 9 superfamily member 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor 6
    Names
    Rac/Cdc42 guanine exchange factor (GEF) 6
    Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
    alpha PIX Rho GTPase guanine nucleotide exchange factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358573.2NP_001345502.1  rho guanine nucleotide exchange factor 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672106, AL672128
      Conserved Domains (5) summary
      cd12060
      Location:864
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      cd00160
      Location:88265
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:296394
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:420520
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:523609
      betaPIX_CC; betaPIX coiled coil
    2. NM_001405168.1NP_001392097.1  rho guanine nucleotide exchange factor 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672106, AL672128
    3. NM_001405169.1NP_001392098.1  rho guanine nucleotide exchange factor 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672106, AL672128
    4. NM_001405170.1NP_001392099.1  rho guanine nucleotide exchange factor 6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL672106, AL672128
      UniProtKB/TrEMBL
      F6WMJ3
    5. NM_001405171.1NP_001392100.1  rho guanine nucleotide exchange factor 6 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL672106, AL672128
    6. NM_001405172.1NP_001392101.1  rho guanine nucleotide exchange factor 6 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL672106, AL672128
    7. NM_001405173.1NP_001392102.1  rho guanine nucleotide exchange factor 6 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL672106, AL672128
    8. NM_001405174.1NP_001392103.1  rho guanine nucleotide exchange factor 6 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL672106, AL672128
    9. NM_001405175.1NP_001392104.1  rho guanine nucleotide exchange factor 6 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL672128
      UniProtKB/TrEMBL
      A2AFJ8
      Related
      ENSMUSP00000110383.3, ENSMUST00000114735.9
    10. NM_001405176.1NP_001392105.1  rho guanine nucleotide exchange factor 6 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL672128
    11. NM_152801.3NP_690014.3  rho guanine nucleotide exchange factor 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL672106, AL672128
      Consensus CDS
      CCDS40984.2
      UniProtKB/Swiss-Prot
      Q8C9V4, Q8K4I3
      UniProtKB/TrEMBL
      F6WMJ3
      Related
      ENSMUSP00000033468.6, ENSMUST00000033468.11

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      56276845..56384119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528314.4XP_006528377.1  rho guanine nucleotide exchange factor 6 isoform X2

      UniProtKB/TrEMBL
      F6WMJ3
      Conserved Domains (7) summary
      cd12060
      Location:185241
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      cd00160
      Location:265442
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:473571
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00307
      Location:27129
      CH; Calponin homology (CH) domain
      pfam16523
      Location:658744
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:592655
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:139183
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    2. XM_006528315.4XP_006528378.1  rho guanine nucleotide exchange factor 6 isoform X3

      UniProtKB/TrEMBL
      F6WMJ3
      Conserved Domains (7) summary
      cd12060
      Location:185241
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      cd00160
      Location:265442
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:473571
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00307
      Location:27129
      CH; Calponin homology (CH) domain
      pfam16523
      Location:651737
      betaPIX_CC; betaPIX coiled coil
      pfam16614
      Location:595648
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16615
      Location:139183
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
    3. XM_036162109.1XP_036018002.1  rho guanine nucleotide exchange factor 6 isoform X4

      Conserved Domains (5) summary
      cd12060
      Location:864
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      cd00160
      Location:88265
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:296394
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:420520
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:523609
      betaPIX_CC; betaPIX coiled coil