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    Chrnb4 cholinergic receptor nicotinic beta 4 subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25103, updated on 3-Dec-2024

    Summary

    Official Symbol
    Chrnb4provided by RGD
    Official Full Name
    cholinergic receptor nicotinic beta 4 subunitprovided by RGD
    Primary source
    RGD:2351
    See related
    EnsemblRapid:ENSRNOG00000014427 AllianceGenome:RGD:2351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables acetylcholine binding activity and heterocyclic compound binding activity. Predicted to be involved in several processes, including membrane depolarization; positive regulation of transmission of nerve impulse; and synaptic signaling. Predicted to act upstream of or within several processes, including behavioral response to nicotine; neuronal action potential; and synaptic transmission involved in micturition. Located in plasma membrane. Part of acetylcholine-gated channel complex. Biomarker of depressive disorder. Human ortholog(s) of this gene implicated in cocaine abuse; lung cancer (multiple); nicotine dependence; and oral cavity cancer. Orthologous to human CHRNB4 (cholinergic receptor nicotinic beta 4 subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 19.8), Thymus (RPKM 5.8) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Chrnb4 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (64312644..64333319, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (55417583..55437027, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (59610489..59629073, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene cholinergic receptor nicotinic alpha 5 subunit Neighboring gene zinc finger CCCH-type containing 15, pseudogene 2 Neighboring gene uncharacterized LOC120094166 Neighboring gene cholinergic receptor nicotinic alpha 3 subunit Neighboring gene ubiquitin conjugating enzyme E2 Q2 Neighboring gene F-box protein 22 Neighboring gene neuregulin 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acetylcholine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acetylcholine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acetylcholine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetylcholine-gated monoatomic cation-selective channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acetylcholine-gated monoatomic cation-selective channel activity IC
    Inferred by Curator
    more info
    PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetylcholine-gated monoatomic cation-selective channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables heterocyclic compound binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to heterocyclic compound binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables heterocyclic compound binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within behavioral response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane depolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transmission of nerve impulse ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within synaptic transmission involved in micturition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic transmission involved in micturition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic transmission, cholinergic IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of acetylcholine-gated channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of acetylcholine-gated channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of acetylcholine-gated channel complex TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in cholinergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    neuronal acetylcholine receptor subunit beta-4
    Names
    Acetylcholine receptor beta 4
    N-alpha 2
    cholinergic receptor, nicotinic beta 4
    cholinergic receptor, nicotinic, beta 4 (neuronal)
    cholinergic receptor, nicotinic, beta polypeptide 4
    neuronal acetylcholine receptor non-alpha-2 chain
    nicotinic acetylcholine receptor-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052806.3NP_434693.1  neuronal acetylcholine receptor subunit beta-4 precursor

      See identical proteins and their annotated locations for NP_434693.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P12392, Q63361
      UniProtKB/TrEMBL
      A0A8I5Y7T1, A6J4N9
      Related
      ENSRNOP00000019458.2, ENSRNOT00000019458.7
      Conserved Domains (2) summary
      TIGR00860
      Location:21483
      LIC; Cation transporter family protein
      cl28912
      Location:53230
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      64312644..64333319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264942.1XP_063121012.1  neuronal acetylcholine receptor subunit beta-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y7T1
    2. XM_063264943.1XP_063121013.1  neuronal acetylcholine receptor subunit beta-4 isoform X2