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    Nova2 NOVA alternative splicing regulator 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292681, updated on 27-Nov-2024

    Summary

    Official Symbol
    Nova2provided by RGD
    Official Full Name
    NOVA alternative splicing regulator 2provided by RGD
    Primary source
    RGD:1308032
    See related
    EnsemblRapid:ENSRNOG00000013847 AllianceGenome:RGD:1308032
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable sequence-specific mRNA binding activity. Predicted to be involved in several processes, including mRNA splicing, via spliceosome; negative regulation of cold-induced thermogenesis; and regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within regulation of RNA metabolic process. Predicted to be active in cytoplasm and nucleus. Orthologous to human NOVA2 (NOVA alternative splicing regulator 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 19.0), Lung (RPKM 15.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nova2 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (87700328..87741755)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (78572253..78613703)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (79831737..79866147)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 61 Neighboring gene uncharacterized LOC134485103 Neighboring gene nanos C2HC-type zinc finger 2 Neighboring gene Myb-related transcription factor, partner of profilin

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    RNA-binding protein Nova-2
    Names
    neuro-oncological ventral antigen 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427170.2NP_001414099.1  RNA-binding protein Nova-2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Related
      ENSRNOP00000107304.1, ENSRNOT00000135317.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      87700328..87741755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)