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    Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362293, updated on 9-Dec-2024

    Summary

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    Symbol
    Dnajb6provided by RGD
    Full Name
    DnaJ heat shock protein family (Hsp40) member B6provided by RGD
    Primary source
    RGD:1308207
    See related
    EnsemblRapid:ENSRNOG00000010353 AllianceGenome:RGD:1308207
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATPase activator activity; identical protein binding activity; and unfolded protein binding activity. Predicted to be involved in several processes, including chaperone-mediated protein folding; intermediate filament organization; and negative regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to act upstream of or within several processes, including chorion development; labyrinthine layer development; and negative regulation of DNA-templated transcription. Predicted to be located in several cellular components, including Z disc; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 1. Orthologous to human DNAJB6 (DnaJ heat shock protein family (Hsp40) member B6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 347.8), Testes (RPKM 286.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnajb6 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (6010081..6232052, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (5452683..5556679, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (2711329..2774969)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene dihydrofolate reductase, pseudogene 1 Neighboring gene interleukin 6 Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene uncharacterized LOC120102202 Neighboring gene 60S ribosomal protein L7 pseudogene Neighboring gene developmental pluripotency-associated protein 3-like Neighboring gene small ribosomal subunit protein uS19-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cell and Context-Dependent Effects of the Heat Shock Protein DNAJB6 on Neuronal Survival. Smith C, et al. Mol Neurobiol, 2016 Oct. PMID 26476842, Free PMC Article
    2. Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently. Chuang JZ, et al. J Biol Chem, 2002 May 31. PMID 11896048
    3. Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant. Rose JM, et al. Hum Mol Genet, 2011 Jan 1. PMID 20889486, Free PMC Article
    4. The Hsp40 family chaperone protein DnaJB6 enhances Schlafen1 nuclear localization which is critical for promotion of cell-cycle arrest in T-cells. Zhang Y, et al. Biochem J, 2008 Jul 15. PMID 18373498
    5. Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein. Izawa I, et al. J Biol Chem, 2000 Nov 3. PMID 10954706

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results conclude that neurotoxicity resulting from elevated DNAJB6 is cell cycle dependent.
      Title: Cell and Context-Dependent Effects of the Heat Shock Protein DNAJB6 on Neuronal Survival.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chaperone-mediated protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chorio-allantoic fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chorion development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intermediate filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within syncytiotrophoblast cell differentiation involved in labyrinthine layer development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily B member 6
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 6
    HSJ-2
    MRJ
    MSJ-1
    heat shock protein J2
    hsp40 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013209.1 → NP_001013227.1  dnaJ homolog subfamily B member 6

      See identical proteins and their annotated locations for NP_001013227.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078908
      UniProtKB/Swiss-Prot
      Q6AYU3
      UniProtKB/TrEMBL
      A0A8I5ZT18
      Related
      ENSRNOP00000041883.2, ENSRNOT00000035996.5
      Conserved Domains (1) summary
      COG0484
      Location:2 → 107
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      6010081..6232052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286219.1 → XP_063142289.1  dnaJ homolog subfamily B member 6 isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y9Y0, A6KJM7
      Related
      ENSRNOP00000079539.1, ENSRNOT00000112530.2

    2. XM_063286218.1 → XP_063142288.1  dnaJ homolog subfamily B member 6 isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y9Y0, A6KJM7

    3. XM_063286214.1 → XP_063142284.1  dnaJ homolog subfamily B member 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZT18

    4. XM_063286217.1 → XP_063142287.1  dnaJ homolog subfamily B member 6 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y9Y0, A6KJM7

    5. XM_063286216.1 → XP_063142286.1  dnaJ homolog subfamily B member 6 isoform X2

      UniProtKB/Swiss-Prot
      Q6AYU3
      UniProtKB/TrEMBL
      A0A8I5ZT18

    6. XM_006235864.5 → XP_006235926.2  dnaJ homolog subfamily B member 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZT18

    7. XM_063286220.1 → XP_063142290.1  dnaJ homolog subfamily B member 6 isoform X7

    8. XM_039107734.2 → XP_038963662.1  dnaJ homolog subfamily B member 6 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AML5, A6KJM9
      Related
      ENSRNOP00000093872.1, ENSRNOT00000118469.2
      Conserved Domains (1) summary
      COG0484
      Location:2 → 107
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RNA

    1. XR_010065653.1 RNA Sequence

    2. XR_010065652.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYU3.1 GenPept UniProtKB/Swiss-Prot:Q6AYU3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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