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    Acad11 acyl-CoA dehydrogenase family, member 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315973, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acad11provided by RGD
    Official Full Name
    acyl-CoA dehydrogenase family, member 11provided by RGD
    Primary source
    RGD:1306270
    See related
    EnsemblRapid:ENSRNOG00000010940 AllianceGenome:RGD:1306270
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306270
    Summary
    Predicted to enable long-chain fatty acyl-CoA dehydrogenase activity; medium-chain fatty acyl-CoA dehydrogenase activity; and very-long-chain fatty acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase. Located in peroxisome. Orthologous to human ACAD11 (acyl-CoA dehydrogenase family member 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 544.8), Kidney (RPKM 225.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acad11 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (113560142..113625346)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (104681346..104746559)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (112594758..112676275)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene nephrocystin 3 Neighboring gene ubiquitin-like modifier activating enzyme 5 Neighboring gene atypical chemokine receptor 4 Neighboring gene uncharacterized LOC120094252 Neighboring gene DnaJ heat shock protein family (Hsp40) member C13 Neighboring gene uncharacterized LOC134480097

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Impact of dietary lipoic acid supplementation on liver mitochondrial bioenergetics and oxidative status on normally fed Wistar rats. Valdecantos MP, et al. Int J Food Sci Nutr, 2019 Nov. PMID 30764676
    2. Identification and characterization of new long chain acyl-CoA dehydrogenases. He M, et al. Mol Genet Metab, 2011 Apr. PMID 21237683, Free PMC Article
    3. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, et al. J Biol Chem, 2004 Jan 2. PMID 14561759
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables medium-chain fatty acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables very-long-chain fatty acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acyl-CoA dehydrogenase family member 11
    Names
    ACAD-11
    acyl-Coenzyme A dehydrogenase family, member 11
    NP_001101651.1
    XP_038937486.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108181.1 → NP_001101651.1  acyl-CoA dehydrogenase family member 11

      See identical proteins and their annotated locations for NP_001101651.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473954
      UniProtKB/Swiss-Prot
      B3DMA2
      UniProtKB/TrEMBL
      A0A8I5ZR07, A0A8I6AMR1
      Related
      ENSRNOP00000036574.4, ENSRNOT00000038383.7
      Conserved Domains (3) summary
      cd01155
      Location:376 → 769
      ACAD_FadE2; Acyl-CoA dehydrogenases similar to fadE2
      PLN02876
      Location:10 → 769
      PLN02876; acyl-CoA dehydrogenase
      cd05154
      Location:42 → 295
      ACAD10_11_N-like; N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      113560142..113625346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081558.2 → XP_038937486.1  acyl-CoA dehydrogenase family member 11 isoform X1

      UniProtKB/TrEMBL
      A0A8L2R5W9
      Related
      ENSRNOP00000072442.2, ENSRNOT00000081281.3
      Conserved Domains (1) summary
      PLN02876
      Location:10 → 539
      PLN02876; acyl-CoA dehydrogenase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B3DMA2.1 GenPept UniProtKB/Swiss-Prot:B3DMA2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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