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    Snrk SNF related kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170837, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Snrkprovided by RGD
    Official Full Name
    SNF related kinaseprovided by RGD
    Primary source
    RGD:69653
    See related
    EnsemblRapid:ENSRNOG00000004050 AllianceGenome:RGD:69653
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in nucleus. Orthologous to human SNRK (SNF related kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 279.9), Brain (RPKM 275.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snrk in Genome Data Viewer
    Location:
    8q32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (130657204..130711461)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (121779704..121833949)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (130749806..130805225)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) Neighboring gene uncharacterized LOC134480254 Neighboring gene uncharacterized LOC134480253 Neighboring gene uncharacterized LOC120094304 Neighboring gene anoctamin 10 Neighboring gene uncharacterized LOC134480255 Neighboring gene uncharacterized LOC102552874

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Negative feedback of SNRK to circ-SNRK regulates cardiac function post-myocardial infarction. Wang ZY, et al. Cell Death Differ, 2022 Apr. PMID 34621049, Free PMC Article
    2. SNRK, a member of the SNF1 family, is related to low K(+)-induced apoptosis of cultured rat cerebellar granule neurons. Yoshida K, et al. Brain Res, 2000 Aug 11. PMID 10930554
    3. Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases. Becker W, et al. Eur J Biochem, 1996 Feb 1. PMID 8654423
    4. Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases. Kertesz N, et al. Gene, 2002 Jul 10. PMID 12234663
    5. Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK. Lefebvre DL, et al. Biochem J, 2001 Apr 15. PMID 11284715, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Negative feedback of SNRK to circ-SNRK regulates cardiac function post-myocardial infarction.
      Title: Negative feedback of SNRK to circ-SNRK regulates cardiac function post-myocardial infarction.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SNF-related serine/threonine-protein kinase
    Names
    SNF1-related kinase
    NP_620188.1
    XP_006244124.1
    XP_038936666.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138833.1 → NP_620188.1  SNF-related serine/threonine-protein kinase

      See identical proteins and their annotated locations for NP_620188.1

      Status: PROVISIONAL

      Source sequence(s)
      X89383
      UniProtKB/Swiss-Prot
      Q63553
      UniProtKB/TrEMBL
      A6I473
      Conserved Domains (2) summary
      cd14339
      Location:288 → 335
      UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
      cd14074
      Location:12 → 269
      STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      130657204..130711461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244062.4 → XP_006244124.1  SNF-related serine/threonine-protein kinase isoform X1

      See identical proteins and their annotated locations for XP_006244124.1

      UniProtKB/Swiss-Prot
      Q63553
      UniProtKB/TrEMBL
      A6I473
      Conserved Domains (2) summary
      cd14339
      Location:288 → 335
      UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
      cd14074
      Location:12 → 269
      STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase

    2. XM_039080738.2 → XP_038936666.1  SNF-related serine/threonine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      Q63553
      UniProtKB/TrEMBL
      A6I473
      Related
      ENSRNOP00000071648.1, ENSRNOT00000079273.3
      Conserved Domains (2) summary
      cd14339
      Location:288 → 335
      UBA_SNRK; UBA domain of SNF-related serine/threonine-protein kinase (SNRK) and similar proteins mainly found in metazoa
      cd14074
      Location:12 → 269
      STKc_SNRK; Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63553.1 GenPept UniProtKB/Swiss-Prot:Q63553

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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