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    Hdac10 histone deacetylase 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362981, updated on 3-Dec-2024

    Summary

    Official Symbol
    Hdac10provided by RGD
    Official Full Name
    histone deacetylase 10provided by RGD
    Primary source
    RGD:1305874
    See related
    EnsemblRapid:ENSRNOG00000031915 AllianceGenome:RGD:1305874
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable histone deacetylase activity; histone deacetylase binding activity; and zinc ion binding activity. Involved in oligodendrocyte development. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of histone deacetylase complex. Orthologous to human HDAC10 (histone deacetylase 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 36.9), Thymus (RPKM 35.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Hdac10 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (122078768..122084457, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (120199126..120205850, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (130102335..130109036, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene TraB domain containing Neighboring gene selenoprotein O Neighboring gene tubulin gamma complex component 6 Neighboring gene mitogen-activated protein kinase 12 Neighboring gene uncharacterized LOC108351526 Neighboring gene mitogen-activated protein kinase 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acetylputrescine deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetylspermidine deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    NOT enables protein lysine deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein lysine deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    NOT enables protein lysine deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epigenetic regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in homologous recombination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in macroautophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in macroautophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oligodendrocyte development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in polyamine deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in polyamine deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mismatch repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mismatch repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mismatch repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermidine deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermidine deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermidine deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone deacetylase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    polyamine deacetylase HDAC10
    Names
    HD10
    NP_001030172.1
    NP_001401901.1
    XP_006242281.1
    XP_038935552.1
    XP_038935553.1
    XP_038935554.1
    XP_038935555.1
    XP_038935556.1
    XP_038935557.1
    XP_038935558.1
    XP_038935559.1
    XP_038935560.1
    XP_038935561.1
    XP_038935562.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035000.2NP_001030172.1  polyamine deacetylase HDAC10 isoform 2

      See identical proteins and their annotated locations for NP_001030172.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q569C4
      UniProtKB/TrEMBL
      A0A8I6AHE1
      Related
      ENSRNOP00000052717.3, ENSRNOT00000055865.5
      Conserved Domains (1) summary
      cl17011
      Location:18302
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    2. NM_001414972.1NP_001401901.1  polyamine deacetylase HDAC10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6A775, A0A8I6AHE1, A6K7J6
      Related
      ENSRNOP00000088972.1, ENSRNOT00000118109.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      122078768..122084457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079625.2XP_038935553.1  polyamine deacetylase HDAC10 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AHE1
      Conserved Domains (1) summary
      cl17011
      Location:18302
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    2. XM_006242219.4XP_006242281.1  polyamine deacetylase HDAC10 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AHE1
      Related
      ENSRNOP00000108360.1, ENSRNOT00000143059.1
      Conserved Domains (1) summary
      cl17011
      Location:18354
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    3. XM_039079624.2XP_038935552.1  polyamine deacetylase HDAC10 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AHE1
      Related
      ENSRNOP00000099349.1, ENSRNOT00000134094.1
      Conserved Domains (1) summary
      cl17011
      Location:18322
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    4. XM_039079627.2XP_038935555.1  polyamine deacetylase HDAC10 isoform X4

      Conserved Domains (1) summary
      cl17011
      Location:6171
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    5. XM_039079628.2XP_038935556.1  polyamine deacetylase HDAC10 isoform X5

      Conserved Domains (1) summary
      cl17011
      Location:129147
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    6. XM_039079631.2XP_038935559.1  polyamine deacetylase HDAC10 isoform X6

      Conserved Domains (1) summary
      cl17011
      Location:104122
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    7. XM_039079626.2XP_038935554.1  polyamine deacetylase HDAC10 isoform X4

      Conserved Domains (1) summary
      cl17011
      Location:6171
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    8. XM_039079630.2XP_038935558.1  polyamine deacetylase HDAC10 isoform X6

      Conserved Domains (1) summary
      cl17011
      Location:104122
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    9. XM_039079629.2XP_038935557.1  polyamine deacetylase HDAC10 isoform X6

      Conserved Domains (1) summary
      cl17011
      Location:104122
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    10. XM_039079632.2XP_038935560.1  polyamine deacetylase HDAC10 isoform X7

      Conserved Domains (1) summary
      cl17011
      Location:180
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    11. XM_039079633.2XP_038935561.1  polyamine deacetylase HDAC10 isoform X8

      Conserved Domains (1) summary
      cl17011
      Location:18354
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    12. XM_039079634.2XP_038935562.1  polyamine deacetylase HDAC10 isoform X9

      Conserved Domains (1) summary
      cl17011
      Location:18302
      Arginase_HDAC; Arginase-like and histone-like hydrolases