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    Nckap1l NCK associated protein 1 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315348, updated on 3-Dec-2024

    Summary

    Official Symbol
    Nckap1lprovided by RGD
    Official Full Name
    NCK associated protein 1 likeprovided by RGD
    Primary source
    RGD:1312032
    See related
    EnsemblRapid:ENSRNOG00000036829 AllianceGenome:RGD:1312032
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hem1
    Summary
    Predicted to enable GTPase activator activity; TORC2 complex binding activity; and protein kinase activator activity. Predicted to be involved in several processes, including lymphocyte homeostasis; negative regulation of cytokine production; and positive regulation of lymphocyte activation. Predicted to be located in cytosol and plasma membrane. Predicted to be part of SCAR complex. Human ortholog(s) of this gene implicated in immunodeficiency 72. Orthologous to human NCKAP1L (NCK associated protein 1 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 380.4), Thymus (RPKM 323.5) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Nckap1l in Genome Data Viewer
    Location:
    7q36
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (136455900..136501384)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (134577470..134622928)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (145068239..145113507)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene gametocyte specific factor 1 Neighboring gene uncharacterized LOC102547836 Neighboring gene gametocyte specific factor 2 Neighboring gene uncharacterized LOC134479586 Neighboring gene phosphodiesterase 1B Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 1A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables TORC2 complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in B cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in B cell homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in B cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in T cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in actin polymerization-dependent cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin polymerization-dependent cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cortical actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cortical actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in erythrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in erythrocyte homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in erythrocyte homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maintenance of cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in myeloid cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myeloid cell homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cytotoxic T cell degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-17 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-17 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of B cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of CD4-positive, alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of CD4-positive, alpha-beta T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of CD8-positive, alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of CD8-positive, alpha-beta T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of TORC2 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell adhesion mediated by integrin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gamma-delta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gamma-delta T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lymphocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lymphocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neutrophil migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phagocytosis, engulfment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of SCAR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SCAR complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SCAR complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nck-associated protein 1-like
    Names
    hematopoietic protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108119.2NP_001101589.1  nck-associated protein 1-like isoform 2

      See identical proteins and their annotated locations for NP_001101589.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6KD11, D3Z8V4
      Related
      ENSRNOP00000058936.3, ENSRNOT00000065753.3
      Conserved Domains (1) summary
      pfam09735
      Location:111095
      Nckap1; Membrane-associated apoptosis protein
    2. NM_001414951.1NP_001401880.1  nck-associated protein 1-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2JUF9, A0A8I6AH32
      Related
      ENSRNOP00000069084.1, ENSRNOT00000088956.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      136455900..136501384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263688.1XP_063119758.1  nck-associated protein 1-like isoform X1

      UniProtKB/TrEMBL
      D3Z8V4