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    Slc5a12 solute carrier family 5 member 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362188, updated on 27-Nov-2024

    Summary

    Official Symbol
    Slc5a12provided by RGD
    Official Full Name
    solute carrier family 5 member 12provided by RGD
    Primary source
    RGD:1311652
    See related
    EnsemblRapid:ENSRNOG00000028008 AllianceGenome:RGD:1311652
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311652
    Summary
    Predicted to enable lactate transmembrane transporter activity and symporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in apical plasma membrane and nucleoplasm. Orthologous to human SLC5A12 (solute carrier family 5 member 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 795.8) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Slc5a12 in Genome Data Viewer
    Location:
    3q34
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (117633885..117683966)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (97179326..97228405)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (101791336..101833044)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101622 Neighboring gene gamma-butyrobetaine hydroxylase 1 Neighboring gene fin bud initiation factor homolog Neighboring gene anoctamin 3 Neighboring gene ribosomal protein L19, pseudogene 1 Neighboring gene mucin 15, cell surface associated

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lactate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lactate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in lactate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sodium-coupled monocarboxylate transporter 2
    Names
    solute carrier family 5 (sodium/glucose cotransporter), member 12
    solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108588.1NP_001102058.1  sodium-coupled monocarboxylate transporter 2

      See identical proteins and their annotated locations for NP_001102058.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A0A8I6ARH5, A6HP16, F1LWL8
      Related
      ENSRNOP00000041926.4, ENSRNOT00000046937.6
      Conserved Domains (1) summary
      cd11520
      Location:3527
      SLC5sbd_SMCT2; Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      117633885..117683966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284156.1XP_063140226.1  sodium-coupled monocarboxylate transporter 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQX1