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    Meltf melanotransferrin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288038, updated on 27-Nov-2024

    Summary

    Official Symbol
    Meltfprovided by RGD
    Official Full Name
    melanotransferrinprovided by RGD
    Primary source
    RGD:1308155
    See related
    EnsemblRapid:ENSRNOG00000001739 AllianceGenome:RGD:1308155
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mfi2; Magea1
    Summary
    Predicted to enable iron ion binding activity. Predicted to be involved in several processes, including negative regulation of substrate adhesion-dependent cell spreading; positive regulation of extracellular matrix disassembly; and positive regulation of plasminogen activation. Predicted to be located in cell surface. Predicted to be active in endosome; extracellular space; and plasma membrane. Orthologous to human MELTF (melanotransferrin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Uterus (RPKM 29.6), Brain (RPKM 3.4) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Meltf in Genome Data Viewer
    Location:
    11q22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (82389420..82411270, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (68884446..68906300, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (72135311..72158106, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352349 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class Z Neighboring gene uncharacterized LOC102549772 Neighboring gene uncharacterized LOC120095672 Neighboring gene uncharacterized LOC134481091 Neighboring gene discs large MAGUK scaffold protein 1 Neighboring gene uncharacterized LOC134481092

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    melanotransferrin
    Names
    antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
    melanoma antigen, family A, 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105872.3NP_001099342.1  melanotransferrin precursor

      See identical proteins and their annotated locations for NP_001099342.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I6AJB3, A6IRV3, D4ADK7
      Related
      ENSRNOP00000002373.5, ENSRNOT00000002373.7
      Conserved Domains (2) summary
      smart00094
      Location:367704
      TR_FER; Transferrin
      pfam00405
      Location:24357
      Transferrin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      82389420..82411270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)