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    Lamc2 laminin subunit gamma 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192362, updated on 27-Nov-2024

    Summary

    Official Symbol
    Lamc2provided by RGD
    Official Full Name
    laminin subunit gamma 2provided by RGD
    Primary source
    RGD:621053
    See related
    EnsemblRapid:ENSRNOG00000002667 AllianceGenome:RGD:621053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable heparin binding activity. Predicted to be involved in several processes, including axon guidance; positive regulation of cell migration; and positive regulation of cell population proliferation. Located in cell cortex; extracellular space; and perinuclear region of cytoplasm. Part of laminin-2 complex. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and lung small cell carcinoma. Orthologous to human LAMC2 (laminin subunit gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 136.0), Heart (RPKM 95.4) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Lamc2 in Genome Data Viewer
    Location:
    13q21
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (67835199..67894694, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (65284664..65344164, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (70566643..70632126, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481571 Neighboring gene ribosomal protein S2, pseudogene 37 Neighboring gene uncharacterized LOC120096279 Neighboring gene nicotinamide nucleotide adenylyltransferase 2 Neighboring gene laminin subunit gamma 1 Neighboring gene ornithine decarboxylase-like Neighboring gene SHC binding and spindle associated 1 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of laminin-2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of laminin-5 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    laminin subunit gamma-2
    Names
    lamimin, gamma 2
    laminin, gamma 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100640.3NP_001094110.1  laminin subunit gamma-2 precursor

      See identical proteins and their annotated locations for NP_001094110.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      F1LRH4
      Related
      ENSRNOP00000037099.5, ENSRNOT00000036947.7
      Conserved Domains (7) summary
      cl14654
      Location:10391159
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00281
      Location:245370
      LamB; Laminin B domain
      COG0840
      Location:7691165
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      cd00055
      Location:83127
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00185
      Location:445481
      TNFRSF; CRD2 [structural motif]
      pfam00053
      Location:139184
      Laminin_EGF; Laminin EGF domain
      cl22855
      Location:437501
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      67835199..67894694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769603.4XP_008767825.1  laminin subunit gamma-2 isoform X1

      See identical proteins and their annotated locations for XP_008767825.1

      UniProtKB/TrEMBL
      F1LRH4
      Related
      ENSRNOP00000099868.1, ENSRNOT00000131794.1
      Conserved Domains (7) summary
      cl14654
      Location:10391159
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00281
      Location:245370
      LamB; Laminin B domain
      COG0840
      Location:7691165
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      cd00055
      Location:83127
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00185
      Location:445481
      TNFRSF; CRD2 [structural motif]
      pfam00053
      Location:139184
      Laminin_EGF; Laminin EGF domain
      cl22855
      Location:437501
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)