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    Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360658, updated on 3-Dec-2024

    Summary

    Official Symbol
    Gga3provided by RGD
    Official Full Name
    golgi associated, gamma adaptin ear containing, ARF binding protein 3provided by RGD
    Primary source
    RGD:1309553
    See related
    EnsemblRapid:ENSRNOG00000027057 AllianceGenome:RGD:1309553
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein transporter activity; small GTPase binding activity; and ubiquitin binding activity. Involved in endocytic recycling. Located in early endosome and recycling endosome. Orthologous to human GGA3 (golgi associated, gamma adaptin ear containing, ARF binding protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 72.5), Adrenal (RPKM 67.2) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gga3 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (101324378..101342373, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (100825427..100843422, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (104137655..104156576, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ferritin light chain 1, pseudogene 10 Neighboring gene nucleoporin 85 Neighboring gene U6 spliceosomal RNA Neighboring gene mitochondrial ribosomal protein S7 Neighboring gene MIF4G domain containing

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endocytic recycling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ADP-ribosylation factor-binding protein GGA3
    Names
    Golgi-localized, gamma ear-containing, ARF-binding protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415686.1NP_001402615.1  ADP-ribosylation factor-binding protein GGA3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      A0A0G2JV04
      UniProtKB/TrEMBL
      A0A8L2R2B7
      Related
      ENSRNOP00000090243.1, ENSRNOT00000114183.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      101324378..101342373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247721.2XP_006247783.1  ADP-ribosylation factor-binding protein GGA3 isoform X1

      UniProtKB/TrEMBL
      A0A8L2R2B7
      Related
      ENSRNOP00000103708.1, ENSRNOT00000135029.1
      Conserved Domains (2) summary
      smart00809
      Location:469583
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd14240
      Location:77163
      GAT_GGA3; GAT domain found in ADP-ribosylation factor-binding protein GGA3