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    Steap2 STEAP2 metalloreductase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312052, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Steap2provided by RGD
    Official Full Name
    STEAP2 metalloreductaseprovided by RGD
    Primary source
    RGD:1307050
    See related
    EnsemblRapid:ENSRNOG00000006076 AllianceGenome:RGD:1307050
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cupric reductase (NADH) activity and ferric-chelate reductase (NADPH) activity. Predicted to be involved in several processes, including Golgi to plasma membrane transport; copper ion import; and regulated exocytosis. Predicted to act upstream of or within copper ion import across plasma membrane and iron ion import across plasma membrane. Predicted to be located in Golgi membrane; cytoplasmic vesicle; and cytosol. Predicted to be active in endosome and plasma membrane. Orthologous to human STEAP2 (STEAP2 metalloreductase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 206.7), Brain (RPKM 50.9) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Steap2 in Genome Data Viewer
    Location:
    4q13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (29302487..29323006)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (28347769..28368177)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (25506604..25527088)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene high mobility group box 3 like 2 Neighboring gene STEAP family member 1 Neighboring gene uncharacterized LOC134486556 Neighboring gene cilia and flagella associated protein 69 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dysregulation of intracellular copper trafficking pathway in a mouse model of mutant copper/zinc superoxide dismutase-linked familial amyotrophic lateral sclerosis. Tokuda E, et al. J Neurochem, 2009 Oct. PMID 19656261
    2. Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer. Korkmaz KS, et al. J Biol Chem, 2002 Sep 27. PMID 12095985
    3. The Steap proteins are metalloreductases. Ohgami RS, et al. Blood, 2006 Aug 15. PMID 16609065, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cupric reductase (NADH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cupric reductase (NADH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ferric-chelate reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferric-chelate reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in copper ion import IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within copper ion import ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within copper ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within iron ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulated exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hormone ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    metalloreductase STEAP2
    Names
    STEAP family member 2, metalloreductase
    six transmembrane epithelial antigen of prostate 2
    six transmembrane epithelial antigen of the prostate 2
    NP_001101316.1
    XP_006236094.1
    XP_006236096.1
    XP_006236098.1
    XP_008760925.1
    XP_038963433.1
    XP_063142035.1
    XP_063142036.1
    XP_063142037.1
    XP_063142039.1
    XP_063142040.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107846.1 → NP_001101316.1  metalloreductase STEAP2

      See identical proteins and their annotated locations for NP_001101316.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474013
      UniProtKB/TrEMBL
      A0A8I6ABY6, A6K253, A6K255, D4A6H3
      Related
      ENSRNOP00000007977.5, ENSRNOT00000007977.7
      Conserved Domains (3) summary
      COG2085
      Location:31 → 216
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:261 → 404
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03807
      Location:33 → 118
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      29302487..29323006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236032.5 → XP_006236094.1  metalloreductase STEAP2 isoform X1

      See identical proteins and their annotated locations for XP_006236094.1

      UniProtKB/TrEMBL
      A0A8I6ABY6, A6K253, A6K255, D4A6H3
      Conserved Domains (3) summary
      COG2085
      Location:31 → 216
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:261 → 404
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03807
      Location:33 → 118
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

    2. XM_006236036.5 → XP_006236098.1  metalloreductase STEAP2 isoform X1

      See identical proteins and their annotated locations for XP_006236098.1

      UniProtKB/TrEMBL
      A0A8I6ABY6, A6K253, A6K255, D4A6H3
      Conserved Domains (3) summary
      COG2085
      Location:31 → 216
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:261 → 404
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03807
      Location:33 → 118
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

    3. XM_063285970.1 → XP_063142040.1  metalloreductase STEAP2 isoform X2

    4. XM_063285966.1 → XP_063142036.1  metalloreductase STEAP2 isoform X2

    5. XM_006236034.5 → XP_006236096.1  metalloreductase STEAP2 isoform X1

      See identical proteins and their annotated locations for XP_006236096.1

      UniProtKB/TrEMBL
      A0A8I6ABY6, A6K253, A6K255, D4A6H3
      Conserved Domains (3) summary
      COG2085
      Location:31 → 216
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:261 → 404
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03807
      Location:33 → 118
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

    6. XM_039107505.2 → XP_038963433.1  metalloreductase STEAP2 isoform X2

      Conserved Domains (1) summary
      COG2085
      Location:31 → 219
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

    7. XM_008762703.4 → XP_008760925.1  metalloreductase STEAP2 isoform X1

      See identical proteins and their annotated locations for XP_008760925.1

      UniProtKB/TrEMBL
      A0A8I6ABY6, A6K253, A6K255, D4A6H3
      Conserved Domains (3) summary
      COG2085
      Location:31 → 216
      COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
      pfam01794
      Location:261 → 404
      Ferric_reduct; Ferric reductase like transmembrane component
      pfam03807
      Location:33 → 118
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

    8. XM_063285965.1 → XP_063142035.1  metalloreductase STEAP2 isoform X1

      UniProtKB/TrEMBL
      A6K255, D4A6H3

    9. XM_063285969.1 → XP_063142039.1  metalloreductase STEAP2 isoform X2

    10. XM_063285967.1 → XP_063142037.1  metalloreductase STEAP2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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