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    Tm9sf4 transmembrane 9 superfamily member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296279, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tm9sf4provided by RGD
    Official Full Name
    transmembrane 9 superfamily member 4provided by RGD
    Primary source
    RGD:1307768
    See related
    EnsemblRapid:ENSRNOG00000009406 AllianceGenome:RGD:1307768
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including positive regulation of protein localization; regulation of intracellular pH; and vacuolar proton-transporting V-type ATPase complex assembly. Predicted to be located in Golgi apparatus and early endosome. Predicted to be active in membrane. Orthologous to human TM9SF4 (transmembrane 9 superfamily member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 223.1), Liver (RPKM 181.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tm9sf4 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (162086758..162135620)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (141627128..141675386)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (148635822..148689961)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene HCK proto-oncogene, Src family tyrosine kinase Neighboring gene uncharacterized LOC102554664 Neighboring gene U6 spliceosomal RNA Neighboring gene testis specific protein, Y-linked 26 Neighboring gene PLAG1 like zinc finger 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The human homologue of Dictyostelium discoideum phg1A is expressed by human metastatic melanoma cells. Lozupone F, et al. EMBO Rep, 2009 Dec. PMID 19893578, Free PMC Article
    2. TM9 family proteins control surface targeting of glycine-rich transmembrane domains. Perrin J, et al. J Cell Sci, 2015 Jul 1. PMID 25999474, Free PMC Article
    3. Human TM9SF4 Is a New Gene Down-Regulated by Hypoxia and Involved in Cell Adhesion of Leukemic Cells. Paolillo R, et al. PLoS One, 2015. PMID 25961573, Free PMC Article
    4. TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells. Lozupone F, et al. Oncogene, 2015 Oct 1. PMID 25659576
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116278

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular monoatomic cation homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein exit from endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein exit from endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein exit from endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein localization to cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of intracellular pH IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vacuolar proton-transporting V-type ATPase complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar proton-transporting V-type ATPase complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane 9 superfamily member 4
    Names
    transmembrane 9 superfamily protein member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025649.1 → NP_001020820.1  transmembrane 9 superfamily member 4 precursor

      See identical proteins and their annotated locations for NP_001020820.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099133
      UniProtKB/Swiss-Prot
      Q4KLL4
      UniProtKB/TrEMBL
      A0A0G2KA25, A6KHT9
      Related
      ENSRNOP00000105668.1, ENSRNOT00000131669.1
      Conserved Domains (1) summary
      pfam02990
      Location:55 → 600
      EMP70; Endomembrane protein 70

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      162086758..162135620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235284.5 → XP_006235346.1  transmembrane 9 superfamily member 4 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KA25
      Related
      ENSRNOP00000111307.1, ENSRNOT00000140126.1
      Conserved Domains (1) summary
      pfam02990
      Location:56 → 601
      EMP70; Endomembrane protein 70
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KLL4.1 GenPept UniProtKB/Swiss-Prot:Q4KLL4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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