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    PEX5L peroxisomal biogenesis factor 5 like [ Homo sapiens (human) ]

    Gene ID: 51555, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PEX5Lprovided by HGNC
    Official Full Name
    peroxisomal biogenesis factor 5 likeprovided by HGNC
    Primary source
    HGNC:HGNC:30024
    See related
    Ensembl:ENSG00000114757 MIM:611058; AllianceGenome:HGNC:30024
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PXR2; PEX5R; PXR2B; PEX5RP; TRIP8b
    Summary
    Enables peroxisome matrix targeting signal-1 binding activity and small GTPase binding activity. Predicted to be involved in protein import into peroxisome matrix, docking and regulation of cAMP-mediated signaling. Predicted to act upstream of or within maintenance of protein location and regulation of membrane potential. Located in cytosol. Part of receptor complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in brain (RPKM 6.5), testis (RPKM 0.6) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See PEX5L in Genome Data Viewer
    Location:
    3q26.33
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (179794958..180036937, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (182598483..182840049, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (179512746..179754725, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14922 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:179370658-179371301 Neighboring gene H3 histone pseudogene 13 Neighboring gene ubiquitin specific peptidase 13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:179446047-179446626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:179446627-179447205 Neighboring gene uncharacterized LOC124909464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20872 Neighboring gene PEX5L antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20873 Neighboring gene uncharacterized LOC124909463 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:179732143-179732642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14925 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:179791123-179791788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:179796465-179796989 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:179819851-179820351 Neighboring gene uncharacterized LOC124909465 Neighboring gene NANOG hESC enhancer GRCh37_chr3:179852449-179852950 Neighboring gene RNA, 5S ribosomal pseudogene 149

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels. Lyman KA, et al. J Biol Chem, 2017 Oct 27. PMID 28887304, Free PMC Article
    2. Genetic variants in DDO and PEX5L in peroxisome-related pathways predict non-small cell lung cancer survival. Chen AS, et al. Mol Carcinog, 2022 Jul. PMID 35502931
    3. Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation. Zolles G, et al. Neuron, 2009 Jun 25. PMID 19555650
    4. Mechanism for the inhibition of the cAMP dependence of HCN ion channels by the auxiliary subunit TRIP8b. Bankston JR, et al. J Biol Chem, 2017 Oct 27. PMID 28864772, Free PMC Article
    5. Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b. Han Y, et al. J Vis Exp, 2016 Nov 11. PMID 27911380, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic variants in DDO and PEX5L in peroxisome-related pathways predict non-small cell lung cancer survival.
      Title: Genetic variants in DDO and PEX5L in peroxisome-related pathways predict non-small cell lung cancer survival.
    2. allosteric coupling of the TRIP8b TPR domains both promotes binding to HCN channels and limits binding to type 1 peroxisomal targeting signal substrates.
      Title: Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels.
    3. TRIP8b competes with a portion of the cAMP-binding site or distorts the binding site by making interactions with the binding pocket, thus acting predominantly as a competitive antagonist that inhibits the cyclic-nucleotide dependence of HCN channels.
      Title: Mechanism for the inhibition of the cAMP dependence of HCN ion channels by the auxiliary subunit TRIP8b.
    4. the sequential formation of a highly stable trimeric complex involving cargo protein, PEX7 and PEX5L stabilizes cargo binding and is a prerequisite for PTS2-mediated peroxisomal import.
      Title: Mechanistic insights into PTS2-mediated peroxisomal protein import: the co-receptor PEX5L drastically increases the interaction strength between the cargo protein and the receptor PEX7.
    5. Data show that Rab8b-interacting protein TRIP8b does not compete with cyclic AMP for the same binding region of hyperpolarization activated cyclic nucleotide gated potassium channel 2 (HCN2).
      Title: Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.
    6. Nedd4-2 plays an important role in the regulation of HCN1 trafficking and may compete with TRIP8b(1a-4) in this process
      Title: Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels.
    7. TRIP8b interacts with the carboxyl-terminal region of HCN channels and regulates their cell-surface expression level and cyclic nucleotide dependence.
      Title: Structure and stoichiometry of an accessory subunit TRIP8b interaction with hyperpolarization-activated cyclic nucleotide-gated channels.
    8. Seizure-dependent plasticity wound is not conditional upon TRIP8b in cerebral cortex.
      Title: TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels.
    9. increasing cAMP levels in cells antagonized the up-regulation of HCN1 channels mediated by a TRIP8b construct binding the CNBD exclusively.
      Title: Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites.
    10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    EBI GWAS Catalog
    Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of peroxisomal biogenesis factor 5-like (PEX5L; PXR2B) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp761J2017

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables peroxisome matrix targeting signal-1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxisome matrix targeting signal-1 binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peroxisome targeting sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein import into peroxisome matrix, docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PEX5-related protein
    Names
    HCN channel auxiliary subunit
    PEX2-related protein
    PEX5-like protein
    Pex5p-related protein
    peroxin-5-related protein
    peroxisome biogenesis factor 5-like
    tetratricopeptide repeat-containing Rab8b-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256750.2 → NP_001243679.1  PEX5-related protein isoform 2

      See identical proteins and their annotated locations for NP_001243679.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes isoform 2.
      Source sequence(s)
      AB032592, AC007687, DA772743
      Consensus CDS
      CCDS58866.1
      UniProtKB/TrEMBL
      B2RAP5
      Related
      ENSP00000263962.8, ENST00000263962.12
      Conserved Domains (4) summary
      COG0457
      Location:264 → 537
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:472 → 500
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:509 → 539
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:508 → 569
      TPR_11; TPR repeat

    2. NM_001256751.2 → NP_001243680.1  PEX5-related protein isoform 3

      See identical proteins and their annotated locations for NP_001243680.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes isoform 3.
      Source sequence(s)
      AB032593, AC007687, AK299633, DA772743
      Consensus CDS
      CCDS58865.1
      UniProtKB/TrEMBL
      B2RAP5
      Related
      ENSP00000419348.1, ENST00000465751.5
      Conserved Domains (2) summary
      TIGR02917
      Location:307 → 537
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:450 → 478
      TPR; TPR repeat [structural motif]

    3. NM_001256752.2 → NP_001243681.1  PEX5-related protein isoform 4

      See identical proteins and their annotated locations for NP_001243681.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes isoform 4.
      Source sequence(s)
      AB032592, AC007687, BC036183, DA772743
      Consensus CDS
      CCDS58867.1
      UniProtKB/TrEMBL
      B2RAP5
      Related
      ENSP00000418440.1, ENST00000485199.5
      Conserved Domains (2) summary
      TIGR02917
      Location:296 → 526
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:439 → 467
      TPR; TPR repeat [structural motif]

    4. NM_001256753.2 → NP_001243682.1  PEX5-related protein isoform 5

      See identical proteins and their annotated locations for NP_001243682.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) encodes isoform 5.
      Source sequence(s)
      AB032593, AC007687, AK294501, DA772743
      Consensus CDS
      CCDS58864.1
      UniProtKB/TrEMBL
      B2RAP5
      Related
      ENSP00000418054.1, ENST00000472994.5
      Conserved Domains (2) summary
      TIGR02917
      Location:272 → 502
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:415 → 443
      TPR; TPR repeat [structural motif]

    5. NM_001256754.2 → NP_001243683.1  PEX5-related protein isoform 6

      See identical proteins and their annotated locations for NP_001243683.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variant 18, encodes isoform 6.
      Source sequence(s)
      AC007687, AC092939, AK295386, AK303716
      Consensus CDS
      CCDS58863.1
      UniProtKB/TrEMBL
      B2RAP5
      Related
      ENSP00000420555.1, ENST00000476138.5
      Conserved Domains (2) summary
      TIGR02917
      Location:288 → 518
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:431 → 459
      TPR; TPR repeat [structural motif]

    6. NM_001256755.2 → NP_001243684.1  PEX5-related protein isoform 7

      See identical proteins and their annotated locations for NP_001243684.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) encodes isoform 7.
      Source sequence(s)
      AC007687, AC092939, AK295349, AK295386, AK303716
      Consensus CDS
      CCDS58862.1
      UniProtKB/TrEMBL
      B7Z219
      Related
      ENSP00000417270.1, ENST00000464614.5
      Conserved Domains (2) summary
      sd00006
      Location:366 → 394
      TPR; TPR repeat [structural motif]
      cl26002
      Location:223 → 453
      TPR_11; TPR repeat

    7. NM_001256756.2 → NP_001243685.1  PEX5-related protein isoform 8

      See identical proteins and their annotated locations for NP_001243685.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 22-28, encodes isoform 8.
      Source sequence(s)
      AB032593, AC007687, AC092939, AK295386
      Consensus CDS
      CCDS58861.1
      UniProtKB/TrEMBL
      B7Z219
      Related
      ENSP00000418665.1, ENST00000468741.5
      Conserved Domains (2) summary
      TIGR02917
      Location:139 → 369
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:282 → 310
      TPR; TPR repeat [structural motif]

    8. NM_001349386.2 → NP_001336315.1  PEX5-related protein isoform 9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) encodes the longest isoform (9).
      Source sequence(s)
      AC007687, AC092939
      UniProtKB/TrEMBL
      B2RAP5
      Conserved Domains (2) summary
      sd00006
      Location:529 → 557
      TPR; TPR repeat [structural motif]
      cl26002
      Location:386 → 616
      TPR_11; TPR repeat

    9. NM_001349387.2 → NP_001336316.1  PEX5-related protein isoform 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variant 11, encodes isoform 10.
      Source sequence(s)
      AC007687, AC092939
      UniProtKB/TrEMBL
      B2RAP5
      Conserved Domains (2) summary
      sd00006
      Location:498 → 526
      TPR; TPR repeat [structural motif]
      cl26002
      Location:355 → 585
      TPR_11; TPR repeat

    10. NM_001349388.2 → NP_001336317.1  PEX5-related protein isoform 10

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variant 10, encodes isoform 10.
      Source sequence(s)
      AC007687, AC092939
      UniProtKB/TrEMBL
      B2RAP5
      Conserved Domains (2) summary
      sd00006
      Location:498 → 526
      TPR; TPR repeat [structural motif]
      cl26002
      Location:355 → 585
      TPR_11; TPR repeat

    11. NM_001349389.2 → NP_001336318.1  PEX5-related protein isoform 11

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) encodes isoform 11.
      Source sequence(s)
      AC007687, AC090024, AC092939
      UniProtKB/TrEMBL
      B2RAP5
      Conserved Domains (2) summary
      sd00006
      Location:496 → 524
      TPR; TPR repeat [structural motif]
      cl26002
      Location:353 → 583
      TPR_11; TPR repeat

    12. NM_001349390.2 → NP_001336319.1  PEX5-related protein isoform 12

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) encodes isoform 12.
      Source sequence(s)
      AC007687, AC092939
      UniProtKB/TrEMBL
      B2RAP5
      Conserved Domains (2) summary
      sd00006
      Location:494 → 522
      TPR; TPR repeat [structural motif]
      cl26002
      Location:351 → 581
      TPR_11; TPR repeat

    13. NM_001349391.2 → NP_001336320.1  PEX5-related protein isoform 13

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14) encodes isoform 13.
      Source sequence(s)
      AC007687, AC092939
      UniProtKB/TrEMBL
      B2RAP5
      Conserved Domains (2) summary
      sd00006
      Location:464 → 492
      TPR; TPR repeat [structural motif]
      cl26002
      Location:321 → 551
      TPR_11; TPR repeat

    14. NM_001349392.2 → NP_001336321.1  PEX5-related protein isoform 14

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variant 16, encodes isoform 14.
      Source sequence(s)
      AC007687, AC092939
      UniProtKB/TrEMBL
      B2RAP5
      Conserved Domains (2) summary
      sd00006
      Location:463 → 491
      TPR; TPR repeat [structural motif]
      cl26002
      Location:320 → 550
      TPR_11; TPR repeat

    15. NM_001349393.2 → NP_001336322.1  PEX5-related protein isoform 14

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variant 15, encodes isoform 14.
      Source sequence(s)
      AC007687, AC092939
      UniProtKB/TrEMBL
      B2RAP5
      Conserved Domains (2) summary
      sd00006
      Location:463 → 491
      TPR; TPR repeat [structural motif]
      cl26002
      Location:320 → 550
      TPR_11; TPR repeat

    16. NM_001349394.2 → NP_001336323.1  PEX5-related protein isoform 15

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17) encodes isoform 15.
      Source sequence(s)
      AC007687, AC092939
      UniProtKB/TrEMBL
      B2RAP5
      Conserved Domains (2) summary
      sd00006
      Location:433 → 461
      TPR; TPR repeat [structural motif]
      cl26002
      Location:290 → 520
      TPR_11; TPR repeat

    17. NM_001349395.2 → NP_001336324.1  PEX5-related protein isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18), as well as variant 6, encodes isoform 6.
      Source sequence(s)
      AC007687, AC092939
      Consensus CDS
      CCDS58863.1
      UniProtKB/TrEMBL
      B2RAP5
      Conserved Domains (2) summary
      TIGR02917
      Location:288 → 518
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:431 → 459
      TPR; TPR repeat [structural motif]

    18. NM_001349396.2 → NP_001336325.1  PEX5-related protein isoform 16

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19) encodes isoform 16.
      Source sequence(s)
      AC007687, AC090024, AC092939
      UniProtKB/TrEMBL
      B7Z219
      Conserved Domains (2) summary
      sd00006
      Location:407 → 435
      TPR; TPR repeat [structural motif]
      cl26002
      Location:264 → 494
      TPR_11; TPR repeat

    19. NM_001349397.2 → NP_001336326.1  PEX5-related protein isoform 17

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20) encodes isoform 17.
      Source sequence(s)
      AC007687, AC092939
      UniProtKB/TrEMBL
      B7Z219
      Conserved Domains (2) summary
      sd00006
      Location:398 → 426
      TPR; TPR repeat [structural motif]
      cl26002
      Location:255 → 485
      TPR_11; TPR repeat

    20. NM_001349398.2 → NP_001336327.1  PEX5-related protein isoform 18

      Status: VALIDATED

      Description
      Transcript Variant: This variant (21) encodes isoform 18.
      Source sequence(s)
      AC007687, AC090024, AC092939
      UniProtKB/TrEMBL
      B7Z219
      Conserved Domains (2) summary
      sd00006
      Location:385 → 413
      TPR; TPR repeat [structural motif]
      cl26002
      Location:242 → 472
      TPR_11; TPR repeat

    21. NM_001349399.2 → NP_001336328.1  PEX5-related protein isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (22), as well as variants 8 and 23-28, encodes isoform 8.
      Source sequence(s)
      AC007687, AC090024, AC092939
      Consensus CDS
      CCDS58861.1
      UniProtKB/TrEMBL
      B7Z219
      Conserved Domains (2) summary
      TIGR02917
      Location:139 → 369
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:282 → 310
      TPR; TPR repeat [structural motif]

    22. NM_001349401.2 → NP_001336330.1  PEX5-related protein isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (23), as well as variants 8, 22, and 24-28, encodes isoform 8.
      Source sequence(s)
      AC007687, AC090024, AC092939
      Consensus CDS
      CCDS58861.1
      UniProtKB/TrEMBL
      B7Z219
      Conserved Domains (2) summary
      TIGR02917
      Location:139 → 369
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:282 → 310
      TPR; TPR repeat [structural motif]

    23. NM_001349404.2 → NP_001336333.1  PEX5-related protein isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (24), as well as variants 8, 22, 23, and 25-28, encodes isoform 8.
      Source sequence(s)
      AC007687, AC090024, AC092939
      Consensus CDS
      CCDS58861.1
      UniProtKB/TrEMBL
      B7Z219
      Conserved Domains (2) summary
      TIGR02917
      Location:139 → 369
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:282 → 310
      TPR; TPR repeat [structural motif]

    24. NM_001349406.2 → NP_001336335.1  PEX5-related protein isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (25), as well as variants 8, 22-24, and 26-28, encodes isoform 8.
      Source sequence(s)
      AC007687, AC092939
      Consensus CDS
      CCDS58861.1
      UniProtKB/TrEMBL
      B7Z219
      Conserved Domains (2) summary
      TIGR02917
      Location:139 → 369
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:282 → 310
      TPR; TPR repeat [structural motif]

    25. NM_001349408.2 → NP_001336337.1  PEX5-related protein isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (26), as well as variants 8, 22-25, 27, and 28, encodes isoform 8.
      Source sequence(s)
      AC007687, AC092939
      Consensus CDS
      CCDS58861.1
      UniProtKB/TrEMBL
      B7Z219
      Conserved Domains (2) summary
      TIGR02917
      Location:139 → 369
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:282 → 310
      TPR; TPR repeat [structural motif]

    26. NM_001349409.2 → NP_001336338.1  PEX5-related protein isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (27), as well as variants 8, 22-26, and 28, encodes isoform 8.
      Source sequence(s)
      AC007687, AC092939
      Consensus CDS
      CCDS58861.1
      UniProtKB/TrEMBL
      B7Z219
      Conserved Domains (2) summary
      TIGR02917
      Location:139 → 369
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:282 → 310
      TPR; TPR repeat [structural motif]

    27. NM_001349410.2 → NP_001336339.1  PEX5-related protein isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (28), as well as variants 8 and 22-27, encodes isoform 8.
      Source sequence(s)
      AC007687, AC092939
      Consensus CDS
      CCDS58861.1
      UniProtKB/TrEMBL
      B7Z219
      Conserved Domains (2) summary
      TIGR02917
      Location:139 → 369
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:282 → 310
      TPR; TPR repeat [structural motif]

    28. NM_016559.3 → NP_057643.1  PEX5-related protein isoform 1

      See identical proteins and their annotated locations for NP_057643.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AB032593, AC007687, DA772743
      Consensus CDS
      CCDS3236.1
      UniProtKB/Swiss-Prot
      B7Z2A5, B7Z305, B7Z318, B7Z5Z5, B7Z8P2, E7EUV8, E7EUZ0, E9PEC1, E9PH97, Q8IYB4, Q9NQD1, Q9P2U3, Q9P2U4
      UniProtKB/TrEMBL
      B2RAP5
      Related
      ENSP00000419975.1, ENST00000467460.6
      Conserved Domains (2) summary
      TIGR02917
      Location:331 → 561
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:474 → 502
      TPR; TPR repeat [structural motif]

    RNA

    1. NR_146167.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC007687, AC092939

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      179794958..180036937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448299.1 → XP_047304255.1  PEX5-related protein isoform X8

      UniProtKB/TrEMBL
      B7Z219

    2. XM_047448298.1 → XP_047304254.1  PEX5-related protein isoform X7

      UniProtKB/TrEMBL
      B7Z219

    3. XM_047448297.1 → XP_047304253.1  PEX5-related protein isoform X6

      UniProtKB/TrEMBL
      B2RAP5

    4. XM_024453591.2 → XP_024309359.1  PEX5-related protein isoform X2

      UniProtKB/TrEMBL
      B2RAP5
      Conserved Domains (2) summary
      TIGR02917
      Location:377 → 607
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:520 → 548
      TPR; TPR repeat [structural motif]

    5. XM_024453593.2 → XP_024309361.1  PEX5-related protein isoform X5

      UniProtKB/TrEMBL
      B7Z219
      Conserved Domains (2) summary
      sd00006
      Location:429 → 457
      TPR; TPR repeat [structural motif]
      cl26002
      Location:286 → 516
      TPR_11; TPR repeat

    6. XM_024453592.2 → XP_024309360.1  PEX5-related protein isoform X3

      UniProtKB/TrEMBL
      B2RAP5
      Conserved Domains (2) summary
      sd00006
      Location:486 → 514
      TPR; TPR repeat [structural motif]
      cl26002
      Location:343 → 573
      TPR_11; TPR repeat

    7. XM_024453590.2 → XP_024309358.1  PEX5-related protein isoform X1

      UniProtKB/TrEMBL
      B2RAP5
      Conserved Domains (2) summary
      sd00006
      Location:551 → 579
      TPR; TPR repeat [structural motif]
      cl26002
      Location:408 → 638
      TPR_11; TPR repeat

    8. XM_011512891.3 → XP_011511193.1  PEX5-related protein isoform X9

      See identical proteins and their annotated locations for XP_011511193.1

      UniProtKB/TrEMBL
      B7Z219
      Conserved Domains (2) summary
      TIGR02917
      Location:139 → 369
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:282 → 310
      TPR; TPR repeat [structural motif]

    9. XM_011512888.3 → XP_011511190.1  PEX5-related protein isoform X4

      UniProtKB/TrEMBL
      B2RAP5
      Conserved Domains (4) summary
      COG0457
      Location:236 → 509
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:444 → 472
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:481 → 511
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:480 → 541
      TPR_11; TPR repeat

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      182598483..182840049 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346825.1 → XP_054202800.1  PEX5-related protein isoform X8

      UniProtKB/TrEMBL
      B7Z219

    2. XM_054346824.1 → XP_054202799.1  PEX5-related protein isoform X7

      UniProtKB/TrEMBL
      B7Z219

    3. XM_054346823.1 → XP_054202798.1  PEX5-related protein isoform X6

      UniProtKB/TrEMBL
      B2RAP5

    4. XM_054346819.1 → XP_054202794.1  PEX5-related protein isoform X2

      UniProtKB/TrEMBL
      B2RAP5

    5. XM_054346822.1 → XP_054202797.1  PEX5-related protein isoform X5

      UniProtKB/TrEMBL
      B7Z219

    6. XM_054346820.1 → XP_054202795.1  PEX5-related protein isoform X3

      UniProtKB/TrEMBL
      B2RAP5

    7. XM_054346818.1 → XP_054202793.1  PEX5-related protein isoform X1

      UniProtKB/TrEMBL
      B2RAP5

    8. XM_054346826.1 → XP_054202801.1  PEX5-related protein isoform X9

      UniProtKB/TrEMBL
      B7Z219

    9. XM_054346821.1 → XP_054202796.1  PEX5-related protein isoform X4

      UniProtKB/TrEMBL
      B2RAP5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IYB4.2 GenPept UniProtKB/Swiss-Prot:Q8IYB4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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