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    TRNP1 TMF1 regulated nuclear protein 1 [ Homo sapiens (human) ]

    Gene ID: 388610, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TRNP1provided by HGNC
    Official Full Name
    TMF1 regulated nuclear protein 1provided by HGNC
    Primary source
    HGNC:HGNC:34348
    See related
    Ensembl:ENSG00000253368 MIM:616824; AllianceGenome:HGNC:34348
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TNRP; TRNP; C1orf225
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in several processes, including cerebellar cortex morphogenesis; neural precursor cell proliferation; and regulation of cell population proliferation. Predicted to be located in euchromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach (RPKM 40.7), esophagus (RPKM 17.0) and 7 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRNP1 in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (26993692..27000886)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (26831731..26838951)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27320183..27327377)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L32 pseudogene 6 Neighboring gene Sharpr-MPRA regulatory region 6295 Neighboring gene oligosaccharyltransferase complex subunit pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27319041-27319542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27319543-27320042 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:27320180-27320680 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27324053-27324658 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:27325387-27326586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27328287-27328890 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27330318-27330962 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27332251-27332894 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27332895-27333538 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27333539-27334182 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:27334827-27335470 Neighboring gene terminal nucleotidyltransferase 5B Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:27338587-27339240 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27339241-27339895 Neighboring gene uncharacterized LOC101928391 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:27361397-27361898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27364454-27364954 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27368765-27369317 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27372795-27373295 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr1:27376127-27376944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27376945-27377760 Neighboring gene Sharpr-MPRA regulatory region 512 Neighboring gene Sharpr-MPRA regulatory region 8493

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. trnp: A conserved mammalian gene encoding a nuclear protein that accelerates cell-cycle progression. Volpe M, et al. DNA Cell Biol, 2006 Jun. PMID 16792503
    2. Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate. Stahl R, et al. Cell, 2013 Apr 25. PMID 23622239
    3. MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development. Wolf EJ, et al. Cell Rep, 2020 May 26. PMID 32460013
    4. HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis. Fujimoto M, et al. Nat Commun, 2022 Jul 29. PMID 35906200, Free PMC Article
    5. A dual-activity topoisomerase complex regulates mRNA translation and turnover. Su S, et al. Nucleic Acids Res, 2022 Jul 8. PMID 35748872, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRNP1 expression levels exhibit regional differences in the cerebral cortex of human fetuses, anticipating radial or tangential expansion.
      Title: Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cerebellar cortex morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neural precursor cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with euchromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    TMF-regulated nuclear protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013642.3 → NP_001013664.2  TMF-regulated nuclear protein 1

      Status: VALIDATED

      Source sequence(s)
      AL356390
      Consensus CDS
      CCDS41289.1
      UniProtKB/Swiss-Prot
      Q6NT89
      Related
      ENSP00000429216.2, ENST00000522111.3
      Conserved Domains (1) summary
      cl22856
      Location:110 → 171
      SNARE; SNARE motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      26993692..27000886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245867.4 → XP_005245924.1  TMF-regulated nuclear protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005245924.1

      UniProtKB/Swiss-Prot
      Q6NT89
      Related
      ENSP00000436467.2, ENST00000531285.2
      Conserved Domains (1) summary
      cl22856
      Location:110 → 171
      SNARE; SNARE motif

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      26831731..26838951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336507.1 → XP_054192482.1  TMF-regulated nuclear protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8E5N8C3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NT89.2 GenPept UniProtKB/Swiss-Prot:Q6NT89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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