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    APLP2 amyloid beta precursor like protein 2 [ Homo sapiens (human) ]

    Gene ID: 334, updated on 10-Dec-2024

    Summary

    Official Symbol
    APLP2provided by HGNC
    Official Full Name
    amyloid beta precursor like protein 2provided by HGNC
    Primary source
    HGNC:HGNC:598
    See related
    Ensembl:ENSG00000084234 MIM:104776; AllianceGenome:HGNC:598
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APPH; APPL2; CDEBP; APLP-2
    Summary
    This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 347.8), lung (RPKM 236.7) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See APLP2 in Genome Data Viewer
    Location:
    11q24.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (130069894..130144805)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (130106007..130180474)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (129939789..130014700)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13105 Neighboring gene NANOG hESC enhancer GRCh37_chr11:129907707-129908249 Neighboring gene MPRA-validated peak1512 silencer Neighboring gene elongin B pseudogene 2 Neighboring gene uncharacterized LOC107984432 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:129938480-129938980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:129938981-129939481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4076 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4077 Neighboring gene ribosomal protein L34 pseudogene 21 Neighboring gene MPRA-validated peak1513 silencer Neighboring gene uncharacterized LOC124902850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:129993119-129993620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:129993621-129994120 Neighboring gene Sharpr-MPRA regulatory region 10235 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:130015754-130016953 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4079 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:130030913-130031412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5752 Neighboring gene ST14 transmembrane serine protease matriptase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:130068001-130068502 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:130079505-130080004 Neighboring gene zinc finger and BTB domain containing 44 Neighboring gene NDUFAF2 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Potential readthrough

    Included gene: ST14

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables heparin binding  
    enables identical protein binding PubMed 
    enables protein binding PubMed 
    enables serine-type endopeptidase inhibitor activity PubMed 
    enables transition metal ion binding  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway PubMed 
    involved_in axonogenesis  
    involved_in central nervous system development  

    General protein information

    Preferred Names
    amyloid beta precursor like protein 2
    Names
    CDEI box-binding protein
    amyloid beta (A4) precursor-like protein 2
    amyloid precursor protein homolog HSD-2
    sperm membrane protein YWK-II
    testicular tissue protein Li 23

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029770.1 RefSeqGene

      Range
      5074..79985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001142276.2 → NP_001135748.1  amyloid beta precursor like protein 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001135748.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2 which lacks an internal segment in the C-terminal region, compared to isoform 1.
      Source sequence(s)
      AK056883, BC000373, BM992563, DC336210
      Consensus CDS
      CCDS44773.1
      UniProtKB/TrEMBL
      A0A140VJE9, B4E3I5
      Related
      ENSP00000345444.5, ENST00000338167.10
      Conserved Domains (6) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:49 → 147
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:697 → 747
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:149 → 204
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:365 → 547
      APP_E2; E2 domain of amyloid precursor protein
    2. NM_001142277.2 → NP_001135749.1  amyloid beta precursor like protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001135749.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the coding region, compared to variant 1. It encodes isoform 3 which lacks two internal segments, compared to isoform 1.
      Source sequence(s)
      AK056883, AK304736, BM992563, DC336210
      Consensus CDS
      CCDS44774.1
      UniProtKB/TrEMBL
      B4E3I5
      Related
      ENSP00000435914.1, ENST00000528499.5
      Conserved Domains (5) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam02177
      Location:49 → 147
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:641 → 691
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:149 → 204
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:309 → 491
      APP_E2; E2 domain of amyloid precursor protein
    3. NM_001142278.2 → NP_001135750.1  amyloid beta precursor like protein 2 isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks multiple exons in the coding region, compared to variant 1. The reading frame is not affected, and this variant encodes isoform 4 which lacks two internal segments, compared to isoform 1.
      Source sequence(s)
      AK056883, BC004371, BM992563, DC336210
      Consensus CDS
      CCDS44775.1
      UniProtKB/Swiss-Prot
      Q06481
      Related
      ENSP00000263575.6, ENST00000345598.9
      Conserved Domains (3) summary
      pfam10515
      Location:468 → 518
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:136 → 318
      APP_E2; E2 domain of amyloid precursor protein
      cl26273
      Location:42 → 137
      APP_N; Amyloid A4 N-terminal heparin-binding
    4. NM_001243299.2 → NP_001230228.1  amyloid beta precursor like protein 2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' exon and also lacks an in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 5 which has a different N-terminus and lacks an internal segment in the C-terminal region, compared to isoform 1.
      Source sequence(s)
      AK056883, AK128162, BC000373, BM992563
      Consensus CDS
      CCDS58196.1
      UniProtKB/TrEMBL
      B4E3I5
      Related
      ENSP00000278756.7, ENST00000278756.7
      Conserved Domains (6) summary
      smart00006
      Location:52 → 214
      A4_EXTRA; amyloid A4
      pfam00014
      Location:319 → 371
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:59 → 157
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:707 → 757
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:159 → 214
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:375 → 557
      APP_E2; E2 domain of amyloid precursor protein
    5. NM_001328682.2 → NP_001315611.1  amyloid beta precursor like protein 2 isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041, BM992563
      UniProtKB/TrEMBL
      B4E3I5
    6. NM_001328684.2 → NP_001315613.1  amyloid beta precursor like protein 2 isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041, BM992563
      UniProtKB/TrEMBL
      B4E3I5
    7. NM_001328685.2 → NP_001315614.1  amyloid beta precursor like protein 2 isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041, BM992563
      UniProtKB/TrEMBL
      B4E3I5
    8. NM_001328686.2 → NP_001315615.1  amyloid beta precursor like protein 2 isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041, BM992563
      UniProtKB/TrEMBL
      B4E3I5
    9. NM_001382526.1 → NP_001369455.1  amyloid beta precursor like protein 2 isoform 10 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (4) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:365 → 545
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:678 → 758
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    10. NM_001382527.1 → NP_001369456.1  amyloid beta precursor like protein 2 isoform 11 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (4) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:365 → 547
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:680 → 758
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    11. NM_001382528.1 → NP_001369457.1  amyloid beta precursor like protein 2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
    12. NM_001382529.1 → NP_001369458.1  amyloid beta precursor like protein 2 isoform 13 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (3) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      COG4942
      Location:407 → 579
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00109
      Location:308 → 361
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    13. NM_001382530.1 → NP_001369459.1  amyloid beta precursor like protein 2 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (4) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:365 → 547
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:643 → 723
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    14. NM_001382531.1 → NP_001369460.1  amyloid beta precursor like protein 2 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (4) summary
      smart00006
      Location:42 → 171
      A4_EXTRA; amyloid A4
      pfam00014
      Location:265 → 317
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:321 → 503
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:636 → 716
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    15. NM_001382532.1 → NP_001369461.1  amyloid beta precursor like protein 2 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (4) summary
      smart00006
      Location:42 → 173
      A4_EXTRA; amyloid A4
      pfam00014
      Location:276 → 328
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:332 → 514
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:635 → 715
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    16. NM_001382533.1 → NP_001369462.1  amyloid beta precursor like protein 2 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (4) summary
      smart00006
      Location:35 → 146
      A4_EXTRA; amyloid A4
      pfam00014
      Location:251 → 303
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:307 → 489
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:622 → 702
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    17. NM_001382534.1 → NP_001369463.1  amyloid beta precursor like protein 2 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (3) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam12925
      Location:309 → 485
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:618 → 698
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    18. NM_001382535.1 → NP_001369464.1  amyloid beta precursor like protein 2 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (3) summary
      smart00006
      Location:42 → 209
      A4_EXTRA; amyloid A4
      pfam12925
      Location:314 → 496
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:617 → 697
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    19. NM_001382536.1 → NP_001369465.1  amyloid beta precursor like protein 2 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (4) summary
      smart00006
      Location:35 → 146
      A4_EXTRA; amyloid A4
      pfam00014
      Location:251 → 303
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:307 → 489
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:610 → 690
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    20. NM_001382537.1 → NP_001369466.1  amyloid beta precursor like protein 2 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (3) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam12925
      Location:309 → 464
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:585 → 665
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    21. NM_001382538.1 → NP_001369467.1  amyloid beta precursor like protein 2 isoform 22 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (4) summary
      smart00006
      Location:42 → 112
      A4_EXTRA; amyloid A4
      pfam00014
      Location:213 → 265
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:269 → 451
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:572 → 652
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    22. NM_001382539.1 → NP_001369468.1  amyloid beta precursor like protein 2 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
    23. NM_001382540.1 → NP_001369469.1  amyloid beta precursor like protein 2 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (3) summary
      smart00006
      Location:35 → 146
      A4_EXTRA; amyloid A4
      pfam12925
      Location:251 → 433
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:554 → 634
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    24. NM_001382541.1 → NP_001369470.1  amyloid beta precursor like protein 2 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (3) summary
      smart00006
      Location:42 → 112
      A4_EXTRA; amyloid A4
      pfam12925
      Location:213 → 395
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:528 → 608
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    25. NM_001382542.1 → NP_001369471.1  amyloid beta precursor like protein 2 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4DTV1
      Conserved Domains (4) summary
      pfam00014
      Location:153 → 205
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12924
      Location:1 → 48
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:209 → 391
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:524 → 604
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    26. NM_001382543.1 → NP_001369472.1  amyloid beta precursor like protein 2 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (3) summary
      smart00006
      Location:42 → 112
      A4_EXTRA; amyloid A4
      pfam12925
      Location:213 → 395
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:516 → 596
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    27. NM_001382544.1 → NP_001369473.1  amyloid beta precursor like protein 2 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      UniProtKB/TrEMBL
      B4E3I5
      Conserved Domains (3) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam12925
      Location:270 → 362
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:483 → 563
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    28. NM_001382545.1 → NP_001369474.1  amyloid beta precursor like protein 2 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      Conserved Domains (3) summary
      smart00006
      Location:42 → 112
      A4_EXTRA; amyloid A4
      pfam12925
      Location:213 → 395
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:465 → 545
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    29. NM_001382546.1 → NP_001369475.1  amyloid beta precursor like protein 2 isoform 30 precursor

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
      Conserved Domains (3) summary
      smart00006
      Location:42 → 137
      A4_EXTRA; amyloid A4
      pfam12925
      Location:136 → 318
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:451 → 531
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    30. NM_001642.3 → NP_001633.1  amyloid beta precursor like protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001633.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK056883, BM992563, DC336210, Z22572
      Consensus CDS
      CCDS8486.1
      UniProtKB/Swiss-Prot
      B3KXX9, H7BXI4, Q06481, Q13861, Q14594, Q14662, Q71U10, Q7M4L3, Q9BT36
      UniProtKB/TrEMBL
      B4E3I5
      Related
      ENSP00000263574.5, ENST00000263574.9
      Conserved Domains (6) summary
      smart00006
      Location:42 → 204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:309 → 361
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:49 → 147
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:709 → 759
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:149 → 204
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:365 → 547
      APP_E2; E2 domain of amyloid precursor protein

    RNA

    1. NR_024515.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in multiple regions, compared to variant 1. The transcript is a candidate for nonsense-mediated decay (NMD).
      Source sequence(s)
      AK056883, BM992563, Z22572
    2. NR_024516.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in multiple regions, compared to variant 1. The transcript is a candidate for nonsense-mediated decay (NMD).
      Source sequence(s)
      AK056883, AK300378, BM992563
    3. NR_168388.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
    4. NR_168389.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
    5. NR_168390.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
    6. NR_168391.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
    7. NR_168392.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
    8. NR_168393.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041
    9. NR_168394.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP001183, AP003041

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      130069894..130144805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      130106007..130180474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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