U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    EPHA7 EPH receptor A7 [ Homo sapiens (human) ]

    Gene ID: 2045, updated on 10-Dec-2024

    Summary

    Official Symbol
    EPHA7provided by HGNC
    Official Full Name
    EPH receptor A7provided by HGNC
    Primary source
    HGNC:HGNC:3390
    See related
    Ensembl:ENSG00000135333 MIM:602190; AllianceGenome:HGNC:3390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EHK3; EK11; EHK-3; HEK11
    Summary
    This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
    Expression
    Broad expression in prostate (RPKM 3.4), kidney (RPKM 2.8) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EPHA7 in Genome Data Viewer
    Location:
    6q16.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (93240020..93419559, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (94452021..94631561, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (93949738..94129277, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:93741721-93742222 Neighboring gene NANOG hESC enhancer GRCh37_chr6:93757947-93758584 Neighboring gene NANOG hESC enhancer GRCh37_chr6:93833219-93833931 Neighboring gene COP9 signalosome subunit 5 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:93881681-93882492 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:93908284-93908784 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_97174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17402 Neighboring gene uncharacterized LOC105377899 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17403 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:94346522-94347093 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:94347094-94347664 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:94373923-94374424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:94374425-94374924 Neighboring gene tumor suppressor TSG1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (16 hits/1295 screens)

    EBI GWAS Catalog

    Description
    Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
    EBI GWAS Catalog
    Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
    EBI GWAS Catalog
    Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population.
    EBI GWAS Catalog
    Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy.
    EBI GWAS Catalog

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding  
    enables GPI-linked ephrin receptor activity  
    enables axon guidance receptor activity  
    enables boss receptor activity  
    enables brain-derived neurotrophic factor receptor activity  
    enables chemorepellent activity  
    enables epidermal growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables growth factor binding  
    enables hepatocyte growth factor receptor activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables insulin receptor activity  
    enables insulin-like growth factor receptor activity  
    enables macrophage colony-stimulating factor receptor activity  
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables protein binding PubMed 
    enables protein tyrosine kinase activity  
    enables protein tyrosine kinase collagen receptor activity  
    enables stem cell factor receptor activity  
    enables transmembrane-ephrin receptor activity  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 34
    Process Evidence Code Pubs
    involved_in Kit signaling pathway  
    involved_in axon guidance  
    involved_in brain development  
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    involved_in branching morphogenesis of a nerve  
    involved_in chromatin remodeling  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in ephrin receptor signaling pathway  
    involved_in ephrin receptor signaling pathway PubMed 
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in fibroblast growth factor receptor signaling pathway  
    involved_in hepatocyte growth factor receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in macrophage colony-stimulating factor signaling pathway  
    involved_in modulation of chemical synaptic transmission  
    involved_in negative chemotaxis  
    involved_in negative regulation of collateral sprouting  
    involved_in negative regulation of synapse assembly  
    involved_in nephric duct morphogenesis  
    involved_in neuron apoptotic process  
    involved_in phosphorylation  
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of neuron apoptotic process  
    involved_in regulation of ERK1 and ERK2 cascade PubMed 
    involved_in regulation of cell-cell adhesion  
    involved_in regulation of cysteine-type endopeptidase activity  
    involved_in regulation of peptidyl-tyrosine phosphorylation PubMed 
    involved_in regulation of postsynapse organization  
    involved_in regulation of protein autophosphorylation  
    involved_in retinal ganglion cell axon guidance  
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    Items 1 - 25 of 34
    Component Evidence Code Pubs
    is_active_in dendrite  
    located_in glutamatergic synapse  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    ephrin type-A receptor 7
    Names
    EPH homology kinase 3
    EPH-like kinase 11
    Eph homology kinase-3
    receptor protein-tyrosine kinase HEK11
    tyrosine-protein kinase receptor EHK-3
    NP_001275558.1
    NP_001275559.1
    NP_001363394.1
    NP_001363395.1
    NP_001363396.1
    NP_001363397.1
    NP_001363398.1
    NP_001363399.1
    NP_001363400.1
    NP_004431.1
    XP_016865855.1
    XP_047274230.1
    XP_054210424.1
    XP_054210425.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033944.1 RefSeqGene

      Range
      5024..184563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001288629.2 → NP_001275558.1  ephrin type-A receptor 7 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001275558.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to isoform 1, and encodes a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AB209269, AL354857, AL591036, L36642
      UniProtKB/TrEMBL
      A0A7P0TBL4
      Conserved Domains (5) summary
      cd09548
      Location:914 → 983
      SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
      cd10485
      Location:30 → 206
      EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7
      cd00063
      Location:443 → 534
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:623 → 889
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam14575
      Location:560 → 625
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    2. NM_001288630.2 → NP_001275559.1  ephrin type-A receptor 7 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL121966
      Consensus CDS
      CCDS75494.1
      UniProtKB/Swiss-Prot
      Q15375
      Related
      ENSP00000358303.1, ENST00000369297.1
      Conserved Domains (1) summary
      cd10485
      Location:30 → 206
      EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7
    3. NM_001376465.1 → NP_001363394.1  ephrin type-A receptor 7 isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121966, AL354857, AL591036
      Consensus CDS
      CCDS93973.1
      UniProtKB/TrEMBL
      A0A7P0TBL4
      Related
      ENSP00000506130.1, ENST00000680224.1
      Conserved Domains (5) summary
      cd09548
      Location:915 → 984
      SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
      cd10485
      Location:30 → 206
      EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7
      cd00063
      Location:443 → 534
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:624 → 890
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam14575
      Location:565 → 626
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    4. NM_001376466.1 → NP_001363395.1  ephrin type-A receptor 7 isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121966, AL354857, AL591036
      UniProtKB/TrEMBL
      A0A7P0TBL4
      Related
      ENSP00000506654.1, ENST00000680082.1
      Conserved Domains (5) summary
      cd09548
      Location:910 → 979
      SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
      cd10485
      Location:30 → 206
      EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7
      cd00063
      Location:443 → 534
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:619 → 885
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam14575
      Location:560 → 621
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    5. NM_001376467.1 → NP_001363396.1  ephrin type-A receptor 7 isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121966, AL354857, AL591036
      UniProtKB/TrEMBL
      A0A7P0TB85
      Related
      ENST00000680473.1
      Conserved Domains (4) summary
      cd10485
      Location:30 → 206
      EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7
      cd00063
      Location:443 → 534
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07699
      Location:275 → 312
      Ephrin_rec_like; Putative ephrin-receptor like
      pfam00041
      Location:333 → 421
      fn3; Fibronectin type III domain
    6. NM_001376468.1 → NP_001363397.1  ephrin type-A receptor 7 isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121966, AL354857, AL591036
      Consensus CDS
      CCDS93974.1
      UniProtKB/TrEMBL
      A0A7P0T9L5, A0A7P0TB85
      Related
      ENSP00000505741.1, ENST00000681532.1
      Conserved Domains (4) summary
      cd10485
      Location:30 → 206
      EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7
      cd00063
      Location:443 → 534
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:333 → 427
      fn3; Fibronectin type III domain
      pfam07699
      Location:275 → 312
      Ephrin_rec_like; Putative ephrin-receptor like
    7. NM_001376469.1 → NP_001363398.1  ephrin type-A receptor 7 isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AL121966, AL591036
      Related
      ENST00000681503.1
      Conserved Domains (3) summary
      cd10485
      Location:30 → 206
      EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7
      cd00063
      Location:332 → 438
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07699
      Location:275 → 312
      Ephrin_rec_like; Putative ephrin-receptor like
    8. NM_001376470.1 → NP_001363399.1  ephrin type-A receptor 7 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL121966, AL354857, AL591036
      Consensus CDS
      CCDS93971.1
      UniProtKB/TrEMBL
      A0A7P0TA58, A0A7P0TBL4
      Related
      ENSP00000505937.1, ENST00000680190.1
      Conserved Domains (5) summary
      cd09548
      Location:843 → 912
      SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
      cd00063
      Location:367 → 458
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:552 → 818
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam14575
      Location:491 → 552
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:1 → 130
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    9. NM_001376471.1 → NP_001363400.1  ephrin type-A receptor 7 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL121966, AL354857, AL591036
      Consensus CDS
      CCDS93972.1
      UniProtKB/TrEMBL
      A0A7P0T9G1, A0A7P0TB85
      Related
      ENSP00000505682.1, ENST00000680953.1
      Conserved Domains (3) summary
      cd00063
      Location:367 → 458
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07699
      Location:199 → 236
      Ephrin_rec_like; Putative ephrin-receptor like
      cl02704
      Location:1 → 130
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    10. NM_004440.4 → NP_004431.1  ephrin type-A receptor 7 isoform 1 precursor

      See identical proteins and their annotated locations for NP_004431.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB209269, AL354857, AL591036, BC126125, DA503795, L36642
      Consensus CDS
      CCDS5031.1
      UniProtKB/Swiss-Prot
      A0AUX7, B2R8W1, B7ZLJ9, B7ZLK0, Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124
      UniProtKB/TrEMBL
      A0A7P0TBL4
      Related
      ENSP00000358309.4, ENST00000369303.9
      Conserved Domains (5) summary
      cd09548
      Location:919 → 988
      SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
      cd10485
      Location:30 → 206
      EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7
      cd00063
      Location:443 → 534
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:628 → 894
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam14575
      Location:565 → 630
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    RNA

    1. NR_164810.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL121966, AL354857, AL591036

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      93240020..93419559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418274.1 → XP_047274230.1  ephrin type-A receptor 7 isoform X1

      UniProtKB/TrEMBL
      A0A7P0T9V9, A0A7P0TB85
      Related
      ENSP00000505801.1, ENST00000681130.1
    2. XM_017010366.3 → XP_016865855.1  ephrin type-A receptor 7 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      94452021..94631561 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354449.1 → XP_054210424.1  ephrin type-A receptor 7 isoform X1

      UniProtKB/TrEMBL
      A0A7P0T9V9, A0A7P0TB85
    2. XM_054354450.1 → XP_054210425.1  ephrin type-A receptor 7 isoform X2

    External link. Please review our privacy policy.